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6 similar compounds to monomer 13216

Wt: 430.9
BDBM13274
Wt: 444.9
BDBM13275
Wt: 502.0
BDBM13276
Wt: 418.9
BDBM13277
Wt: 472.9
BDBM13278
Wt: 489.9
BDBM50225370

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 13274,13275,13276,13277,13278,50225370   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM13274
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12s |...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(ncn2)N2CCOCC2)s1
Show InChI InChI=1S/C19H19ClN6O2S/c1-12-3-2-4-13(20)17(12)25-18(27)14-10-21-19(29-14)24-15-9-16(23-11-22-15)26-5-7-28-8-6-26/h2-4,9-11H,5-8H2,1H3,(H,25,27)(H,21,22,23,24)
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Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13275
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12t |...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(nc(C)n2)N2CCOCC2)s1
Show InChI InChI=1S/C20H21ClN6O2S/c1-12-4-3-5-14(21)18(12)26-19(28)15-11-22-20(30-15)25-16-10-17(24-13(2)23-16)27-6-8-29-9-7-27/h3-5,10-11H,6-9H2,1-2H3,(H,26,28)(H,22,23,24,25)
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PubMed
n/an/a 1.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13276
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12u |...)
Show SMILES Cc1nc(NCCCN2CCOCC2)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1
Show InChI InChI=1S/C23H28ClN7O2S/c1-15-5-3-6-17(24)21(15)30-22(32)18-14-26-23(34-18)29-20-13-19(27-16(2)28-20)25-7-4-8-31-9-11-33-12-10-31/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,30,32)(H2,25,26,27,28,29)
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PubMed
n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50225370
PNG
(CHEMBL240158 | N-(2-chloro-6-methylphenyl)-2-(6-(4...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCF)CC1
Show InChI InChI=1S/C22H25ClFN7OS/c1-14-4-3-5-16(23)20(14)29-21(32)17-13-25-22(33-17)28-18-12-19(27-15(2)26-18)31-10-8-30(7-6-24)9-11-31/h3-5,12-13H,6-11H2,1-2H3,(H,29,32)(H,25,26,27,28)
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n/an/a 3.5n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Src


J Med Chem 50: 5853-7 (2007)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13278
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12w |...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCC(CO)CC1
Show InChI InChI=1S/C22H25ClN6O2S/c1-13-4-3-5-16(23)20(13)28-21(31)17-11-24-22(32-17)27-18-10-19(26-14(2)25-18)29-8-6-15(12-30)7-9-29/h3-5,10-11,15,30H,6-9,12H2,1-2H3,(H,28,31)(H,24,25,26,27)
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PubMed
n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50225370
PNG
(CHEMBL240158 | N-(2-chloro-6-methylphenyl)-2-(6-(4...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCF)CC1
Show InChI InChI=1S/C22H25ClFN7OS/c1-14-4-3-5-16(23)20(14)29-21(32)17-13-25-22(33-17)28-18-12-19(27-15(2)26-18)31-10-8-30(7-6-24)9-11-31/h3-5,12-13H,6-11H2,1-2H3,(H,29,32)(H,25,26,27,28)
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Article
PubMed
n/an/a 9.10n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Abl kinase


J Med Chem 50: 5853-7 (2007)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13277
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12v |...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(NCCO)nc(C)n2)s1
Show InChI InChI=1S/C18H19ClN6O2S/c1-10-4-3-5-12(19)16(10)25-17(27)13-9-21-18(28-13)24-15-8-14(20-6-7-26)22-11(2)23-15/h3-5,8-9,26H,6-7H2,1-2H3,(H,25,27)(H2,20,21,22,23,24)
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Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair