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29 similar compounds to monomer 50131131

Wt: 423.9
BDBM13356
Wt: 408.9
BDBM50131116
Wt: 468.9
BDBM50131117
Wt: 425.8
BDBM50131120
Wt: 395.8
BDBM50131121
Wt: 395.8
BDBM50131122
Wt: 422.9
BDBM50131123
Wt: 394.8
BDBM50131125
Wt: 417.5
BDBM50131126
Wt: 409.8
BDBM50131128
Wt: 410.8
BDBM50131132
Wt: 452.9
BDBM50131137
Wt: 383.8
BDBM50131138
Wt: 409.8
BDBM50131139
Wt: 393.8
BDBM50131140
Displayed 1 to 15 (of 29 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 13356,50131116,50131117,50131120,50131121,50131122,50131123,50131125,50131126,50131128,50131132,50131137,50131138,50131139,50131140   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM13356
PNG
(CHEMBL84624 | N-(2-chloro-6-methylphenyl)-2-[(2,6-...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C21H18ClN5OS/c1-11-5-4-6-15(22)19(11)27-20(28)14-7-8-16-17(10-14)29-21(25-16)26-18-9-12(2)23-13(3)24-18/h4-10H,1-3H3,(H,27,28)(H,23,24,25,26)
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131117
PNG
(2-[2-(2-Hydroxy-ethylamino)-6-methyl-pyrimidin-4-y...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(NCCO)n1
Show InChI InChI=1S/C22H21ClN6O2S/c1-12-4-3-5-15(23)19(12)29-20(31)14-6-7-16-17(11-14)32-22(26-16)28-18-10-13(2)25-21(27-18)24-8-9-30/h3-7,10-11,30H,8-9H2,1-2H3,(H,29,31)(H2,24,25,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131137
PNG
(2-(2-Methyl-6-methylaminomethyl-pyrimidin-4-ylamin...)
Show SMILES CNCc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H21ClN6OS/c1-12-5-4-6-16(23)20(12)29-21(30)14-7-8-17-18(9-14)31-22(27-17)28-19-10-15(11-24-3)25-13(2)26-19/h4-10,24H,11H2,1-3H3,(H,29,30)(H,25,26,27,28)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131117
PNG
(2-[2-(2-Hydroxy-ethylamino)-6-methyl-pyrimidin-4-y...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(NCCO)n1
Show InChI InChI=1S/C22H21ClN6O2S/c1-12-4-3-5-15(23)19(12)29-20(31)14-6-7-16-17(11-14)32-22(26-16)28-18-10-13(2)25-21(27-18)24-8-9-30/h3-7,10-11,30H,8-9H2,1-2H3,(H,29,31)(H2,24,25,26,27,28)
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131116
PNG
(2-(5-Methyl-pyridin-2-ylamino)-benzothiazole-6-car...)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc1
Show InChI InChI=1S/C21H17ClN4OS/c1-12-6-9-18(23-11-12)25-21-24-16-8-7-14(10-17(16)28-21)20(27)26-19-13(2)4-3-5-15(19)22/h3-11H,1-2H3,(H,26,27)(H,23,24,25)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50131117
PNG
(2-[2-(2-Hydroxy-ethylamino)-6-methyl-pyrimidin-4-y...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(NCCO)n1
Show InChI InChI=1S/C22H21ClN6O2S/c1-12-4-3-5-15(23)19(12)29-20(31)14-6-7-16-17(11-14)32-22(26-16)28-18-10-13(2)25-21(27-18)24-8-9-30/h3-7,10-11,30H,8-9H2,1-2H3,(H,29,31)(H2,24,25,26,27,28)
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Src protein tryrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13356
PNG
(CHEMBL84624 | N-(2-chloro-6-methylphenyl)-2-[(2,6-...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C21H18ClN5OS/c1-11-5-4-6-15(22)19(11)27-20(28)14-7-8-16-17(10-14)29-21(25-16)26-18-9-12(2)23-13(3)24-18/h4-10H,1-3H3,(H,27,28)(H,23,24,25,26)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131121
PNG
(2-(Pyrazin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cnccn3)sc2c1
Show InChI InChI=1S/C19H14ClN5OS/c1-11-3-2-4-13(20)17(11)25-18(26)12-5-6-14-15(9-12)27-19(23-14)24-16-10-21-7-8-22-16/h2-10H,1H3,(H,25,26)(H,22,23,24)
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n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131120
PNG
(2-(6-Methoxy-pyrimidin-4-ylamino)-benzothiazole-6-...)
Show SMILES COc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)ncn1
Show InChI InChI=1S/C20H16ClN5O2S/c1-11-4-3-5-13(21)18(11)26-19(27)12-6-7-14-15(8-12)29-20(24-14)25-16-9-17(28-2)23-10-22-16/h3-10H,1-2H3,(H,26,27)(H,22,23,24,25)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131122
PNG
(2-(Pyrimidin-4-ylamino)-benzothiazole-6-carboxylic...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccncn3)sc2c1
Show InChI InChI=1S/C19H14ClN5OS/c1-11-3-2-4-13(20)17(11)25-18(26)12-5-6-14-15(9-12)27-19(23-14)24-16-7-8-21-10-22-16/h2-10H,1H3,(H,25,26)(H,21,22,23,24)
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n/an/a 27n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131123
PNG
(2-(4-Ethyl-pyridin-2-ylamino)-benzothiazole-6-carb...)
Show SMILES CCc1ccnc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)c1
Show InChI InChI=1S/C22H19ClN4OS/c1-3-14-9-10-24-19(11-14)26-22-25-17-8-7-15(12-18(17)29-22)21(28)27-20-13(2)5-4-6-16(20)23/h4-12H,3H2,1-2H3,(H,27,28)(H,24,25,26)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131126
PNG
(2-(2,6-Dimethyl-pyrimidin-4-ylamino)-benzothiazole...)
Show SMILES Cc1cc(C)c(NC(=O)c2ccc3nc(Nc4cc(C)nc(C)n4)sc3c2)c(C)c1
Show InChI InChI=1S/C23H23N5OS/c1-12-8-13(2)21(14(3)9-12)28-22(29)17-6-7-18-19(11-17)30-23(26-18)27-20-10-15(4)24-16(5)25-20/h6-11H,1-5H3,(H,28,29)(H,24,25,26,27)
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n/an/a 53n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131125
PNG
(2-(Pyridin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccn3)sc2c1
Show InChI InChI=1S/C20H15ClN4OS/c1-12-5-4-6-14(21)18(12)25-19(26)13-8-9-15-16(11-13)27-20(23-15)24-17-7-2-3-10-22-17/h2-11H,1H3,(H,25,26)(H,22,23,24)
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131128
PNG
(2-(4-Amino-pyridin-2-ylamino)-benzothiazole-6-carb...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(N)ccn3)sc2c1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-3-2-4-14(21)18(11)26-19(27)12-5-6-15-16(9-12)28-20(24-15)25-17-10-13(22)7-8-23-17/h2-10H,1H3,(H,26,27)(H3,22,23,24,25)
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n/an/a 403n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131132
PNG
(2-(6-Amino-pyrimidin-4-ylamino)-benzothiazole-6-ca...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3cc(N)ncn3)sc2c1
Show InChI InChI=1S/C19H15ClN6OS/c1-10-3-2-4-12(20)17(10)26-18(27)11-5-6-13-14(7-11)28-19(24-13)25-16-8-15(21)22-9-23-16/h2-9H,1H3,(H,26,27)(H3,21,22,23,24,25)
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n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131137
PNG
(2-(2-Methyl-6-methylaminomethyl-pyrimidin-4-ylamin...)
Show SMILES CNCc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H21ClN6OS/c1-12-5-4-6-16(23)20(12)29-21(30)14-7-8-17-18(9-14)31-22(27-17)28-19-10-15(11-24-3)25-13(2)26-19/h4-10,24H,11H2,1-3H3,(H,29,30)(H,25,26,27,28)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131139
PNG
(2-(6-Methyl-pyrimidin-4-ylamino)-benzothiazole-6-c...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)ncn1
Show InChI InChI=1S/C20H16ClN5OS/c1-11-4-3-5-14(21)18(11)26-19(27)13-6-7-15-16(9-13)28-20(24-15)25-17-8-12(2)22-10-23-17/h3-10H,1-2H3,(H,26,27)(H,22,23,24,25)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131138
PNG
(2-(1H-Imidazol-2-ylamino)-benzothiazole-6-carboxyl...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ncc[nH]3)sc2c1
Show InChI InChI=1S/C18H14ClN5OS/c1-10-3-2-4-12(19)15(10)23-16(25)11-5-6-13-14(9-11)26-18(22-13)24-17-20-7-8-21-17/h2-9H,1H3,(H,23,25)(H2,20,21,22,24)
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n/an/a>3.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131140
PNG
(2-Phenylamino-benzothiazole-6-carboxylic acid (2-c...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccc3)sc2c1
Show InChI InChI=1S/C21H16ClN3OS/c1-13-6-5-9-16(22)19(13)25-20(26)14-10-11-17-18(12-14)27-21(24-17)23-15-7-3-2-4-8-15/h2-12H,1H3,(H,23,24)(H,25,26)
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n/an/a 327n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50131117
PNG
(2-[2-(2-Hydroxy-ethylamino)-6-methyl-pyrimidin-4-y...)
Show SMILES Cc1cc(Nc2nc3ccc(cc3s2)C(=O)Nc2c(C)cccc2Cl)nc(NCCO)n1
Show InChI InChI=1S/C22H21ClN6O2S/c1-12-4-3-5-15(23)19(12)29-20(31)14-6-7-16-17(11-14)32-22(26-16)28-18-10-13(2)25-21(27-18)24-8-9-30/h3-7,10-11,30H,8-9H2,1-2H3,(H,29,31)(H2,24,25,26,27,28)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Fyn protein kinase


Citation and Details
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50131125
PNG
(2-(Pyridin-2-ylamino)-benzothiazole-6-carboxylic a...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(Nc3ccccn3)sc2c1
Show InChI InChI=1S/C20H15ClN4OS/c1-12-5-4-6-14(21)18(12)25-19(26)13-8-9-15-16(11-13)27-20(23-15)24-17-7-2-3-10-22-17/h2-11H,1H3,(H,25,26)(H,22,23,24)
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n/an/a 84n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair