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11 similar compounds to monomer 134266

Compile data set for download or QSAR
Wt: 583.0
BDBM134259
Wt: 600.9
BDBM134260
Wt: 598.0
BDBM134261
Wt: 616.0
BDBM134262
Wt: 615.0
BDBM134267
Wt: 580.0
BDBM134268
Wt: 631.0
BDBM134269
Wt: 601.9
BDBM134271
Wt: 593.0
BDBM134273
Wt: 579.0
BDBM134275
Wt: 594.0
BDBM134276

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 134259,134260,134261,134262,134267,134268,134269,134271,134273,134275,134276   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM134259
PNG
(US8846660, 26)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(cc2)C(O)=O)C1=O)=N/Oc1ccc(F)cc1
Show InChI InChI=1S/C29H28ClFN4O6/c1-17(18-3-5-19(6-4-18)28(37)38)33-29(39)35-16-26(34-41-24-10-8-23(31)9-11-24)32-15-21(27(35)36)13-20-14-22(30)7-12-25(20)40-2/h3-12,14,17,21H,13,15-16H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t17-,21?/m1/s1
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US Patent
n/an/a 50n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134260
PNG
(US8846660, 27)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(cc2)C(O)=O)C1=O)=N/Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C29H27ClF2N4O6/c1-16(17-3-5-18(6-4-17)28(38)39)34-29(40)36-15-26(35-42-24-12-22(31)11-23(32)13-24)33-14-20(27(36)37)9-19-10-21(30)7-8-25(19)41-2/h3-8,10-13,16,20H,9,14-15H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,20?/m1/s1
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n/an/a 20n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134261
PNG
(US8846660, 29)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1ccc(F)cc1
Show InChI InChI=1S/C29H29ClFN5O6/c1-16(17-3-9-23(28(38)39)24(32)13-17)34-29(40)36-15-26(35-42-22-7-5-21(31)6-8-22)33-14-19(27(36)37)11-18-12-20(30)4-10-25(18)41-2/h3-10,12-13,16,19H,11,14-15,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,19?/m1/s1
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US Patent
n/an/a 10n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134262
PNG
(US8846660, 30)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C29H28ClF2N5O6/c1-15(16-3-5-23(28(39)40)24(33)9-16)35-29(41)37-14-26(36-43-22-11-20(31)10-21(32)12-22)34-13-18(27(37)38)7-17-8-19(30)4-6-25(17)42-2/h3-6,8-12,15,18H,7,13-14,33H2,1-2H3,(H,34,36)(H,35,41)(H,39,40)/t15-,18?/m1/s1
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US Patent
n/an/a 4n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134267
PNG
(US8846660, 41)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C30H29ClF2N4O6/c1-17(19-5-3-18(4-6-19)9-28(38)39)35-30(41)37-16-27(36-43-25-13-23(32)12-24(33)14-25)34-15-21(29(37)40)10-20-11-22(31)7-8-26(20)42-2/h3-8,11-14,17,21H,9-10,15-16H2,1-2H3,(H,34,36)(H,35,41)(H,38,39)/t17-,21?/m1/s1
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n/an/a 3n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134276
PNG
(US8846660, 76)
Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C30H32ClN5O6/c1-3-25(18-9-11-23(29(38)39)24(32)15-18)34-30(40)36-17-27(35-42-22-7-5-4-6-8-22)33-16-20(28(36)37)13-19-14-21(31)10-12-26(19)41-2/h4-12,14-15,20,25H,3,13,16-17,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t20?,25-/m1/s1
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n/an/a 9n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134269
PNG
(US8846660, 44)
Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1cc(F)cc(F)c1)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C30H29ClF2N4O7/c1-3-24(16-4-6-23(29(40)41)25(38)10-16)35-30(42)37-15-27(36-44-22-12-20(32)11-21(33)13-22)34-14-18(28(37)39)8-17-9-19(31)5-7-26(17)43-2/h4-7,9-13,18,24,38H,3,8,14-15H2,1-2H3,(H,34,36)(H,35,42)(H,40,41)/t18?,24-/m1/s1
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n/an/a 20n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134271
PNG
(US8846660, 53)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)NCc2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1
Show InChI InChI=1S/C28H26ClF2N5O6/c1-41-24-5-3-18(29)8-16(24)7-17-13-33-25(35-42-21-10-19(30)9-20(31)11-21)14-36(26(17)37)28(40)34-12-15-2-4-22(27(38)39)23(32)6-15/h2-6,8-11,17H,7,12-14,32H2,1H3,(H,33,35)(H,34,40)(H,38,39)
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n/an/a 40n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134273
PNG
(US8846660, 64)
Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C31H33ClN4O6/c1-3-26(21-11-9-20(10-12-21)15-29(37)38)34-31(40)36-19-28(35-42-25-7-5-4-6-8-25)33-18-23(30(36)39)16-22-17-24(32)13-14-27(22)41-2/h4-14,17,23,26H,3,15-16,18-19H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t23?,26-/m1/s1
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n/an/a 30n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134275
PNG
(US8846660, 73)
Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C30H31ClN4O6/c1-3-25(19-8-7-9-20(14-19)29(37)38)33-30(39)35-18-27(34-41-24-10-5-4-6-11-24)32-17-22(28(35)36)15-21-16-23(31)12-13-26(21)40-2/h4-14,16,22,25H,3,15,17-18H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t22?,25-/m1/s1
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n/an/a 30n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair
Chymase


(Homo sapiens (Human))
BDBM134268
PNG
(US8846660, 42)
Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccccn1
Show InChI InChI=1S/C29H30ClN5O6/c1-18(20-8-6-19(7-9-20)13-27(36)37)33-29(39)35-17-25(34-41-26-5-3-4-12-31-26)32-16-22(28(35)38)14-21-15-23(30)10-11-24(21)40-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,36,37)/t18-,22?/m1/s1
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n/an/a 20n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...


US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair