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142 similar compounds to monomer 135431

Compile data set for download or QSAR
Wt: 552.0
BDBM148142
Wt: 554.0
BDBM148143
Wt: 579.0
BDBM148144
Wt: 699.1
BDBM148145
Wt: 565.0
BDBM148146
Wt: 655.1
BDBM148147
Wt: 579.0
BDBM148148
Wt: 538.0
BDBM135166
Wt: 540.0
BDBM135217
Wt: 565.0
BDBM135219
Wt: 552.0
BDBM135222
Wt: 552.0
BDBM135294
Wt: 699.1
BDBM135233
Wt: 565.0
BDBM135234
Wt: 655.1
BDBM135235
Displayed 1 to 15 (of 142 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 148142,148143,148144,148145,148146,148147,148148,135166,135217,135219,135222,135294,135233,135234,135235   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135166
PNG
(US8846657, 3.58)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C27H32ClN7O3/c1-15-4-6-17(7-5-15)13-35-24-21(31-26(35)34-14-20(37-3)8-16(34)2)10-22(25-32-27(36)38-33-25)30-23(24)18-9-19(28)12-29-11-18/h9-12,15-17,20H,4-8,13-14H2,1-3H3,(H,32,33,36)/t15-,16-,17-,20-/s2
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n/an/a 4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148148
PNG
(US8962611, 5.3)
Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(C)=O)CC1
Show InChI InChI=1/C29H35ClN8O3/c1-16-5-7-20(8-6-16)15-37-26-23(33-28(37)38-17(2)13-36(19(4)39)14-18(38)3)10-24(27-34-29(40)41-35-27)32-25(26)21-9-22(30)12-31-11-21/h9-12,16-18,20H,5-8,13-15H2,1-4H3,(H,34,35,40)/t16-,17-,18-,20-/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135219
PNG
(US8846657, 3.112)
Show SMILES CCNC(=O)[C@@H]1CCCN1c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H33ClN8O3/c1-3-31-26(38)22-5-4-10-36(22)27-33-20-12-21(25-34-28(39)40-35-25)32-23(18-11-19(29)14-30-13-18)24(20)37(27)15-17-8-6-16(2)7-9-17/h11-14,16-17,22H,3-10,15H2,1-2H3,(H,31,38)(H,34,35,39)/t16-,17-,22-/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135233
PNG
(US8846657, 3.126)
Show SMILES C[C@H]1CCC(Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CN(CC[C@@H]23)C(=O)OCc2ccccc2)CC1
Show InChI InChI=1/C36H39ClN8O5/c1-22-7-9-23(10-8-22)19-45-32-27(16-28(33-41-35(46)50-42-33)39-31(32)25-15-26(37)18-38-17-25)40-34(45)44-13-14-48-30-20-43(12-11-29(30)44)36(47)49-21-24-5-3-2-4-6-24/h2-6,15-18,22-23,29-30H,7-14,19-21H2,1H3,(H,41,42,46)/t22-,23?,29-,30-/s2
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Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135234
PNG
(US8846657, 3.127)
Show SMILES C[C@H]1CCC(Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CNCC[C@@H]23)CC1
Show InChI InChI=1/C28H33ClN8O3/c1-16-2-4-17(5-3-16)15-37-25-20(33-27(37)36-8-9-39-23-14-30-7-6-22(23)36)11-21(26-34-28(38)40-35-26)32-24(25)18-10-19(29)13-31-12-18/h10-13,16-17,22-23,30H,2-9,14-15H2,1H3,(H,34,35,38)/t16-,17?,22-,23-/s2
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n/an/a 512n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135235
PNG
(US8846657, 3.128)
Show SMILES C[C@H]1CCC(Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CN(Cc4ccccc4)CC[C@@H]23)CC1
Show InChI InChI=1/C35H39ClN8O3/c1-22-7-9-24(10-8-22)20-44-32-27(16-28(33-40-35(45)47-41-33)38-31(32)25-15-26(36)18-37-17-25)39-34(44)43-13-14-46-30-21-42(12-11-29(30)43)19-23-5-3-2-4-6-23/h2-6,15-18,22,24,29-30H,7-14,19-21H2,1H3,(H,40,41,45)/t22-,24?,29-,30-/s2
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n/an/a 129n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135294
PNG
(US8846657, 4.11 | US8846657, 4.14)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C(C)[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-15-5-7-18(8-6-15)17(3)36-25-22(32-27(36)35-14-21(38-4)9-16(35)2)11-23(26-33-28(37)39-34-26)31-24(25)19-10-20(29)13-30-12-19/h10-13,15-18,21H,5-9,14H2,1-4H3,(H,33,34,37)/t15-,16-,17?,18-,21-/s2
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135294
PNG
(US8846657, 4.11 | US8846657, 4.14)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C(C)[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-15-5-7-18(8-6-15)17(3)36-25-22(32-27(36)35-14-21(38-4)9-16(35)2)11-23(26-33-28(37)39-34-26)31-24(25)19-10-20(29)13-30-12-19/h10-13,15-18,21H,5-9,14H2,1-4H3,(H,33,34,37)/t15-,16-,17?,18-,21-/s2
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n/an/a 2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135166
PNG
(US8846657, 3.58)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C27H32ClN7O3/c1-15-4-6-17(7-5-15)13-35-24-21(31-26(35)34-14-20(37-3)8-16(34)2)10-22(25-32-27(36)38-33-25)30-23(24)18-9-19(28)12-29-11-18/h9-12,15-17,20H,4-8,13-14H2,1-3H3,(H,32,33,36)/t15-,16-,17-,20-/s2
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n/an/a 4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148142
PNG
(US8962611, 3.91)
Show SMILES CC(C)[C@@H]1C[C@@H](O)CN1c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-15(2)23-9-20(37)14-35(23)27-32-21-10-22(26-33-28(38)39-34-26)31-24(18-8-19(29)12-30-11-18)25(21)36(27)13-17-6-4-16(3)5-7-17/h8,10-12,15-17,20,23,37H,4-7,9,13-14H2,1-3H3,(H,33,34,38)/t16-,17-,20-,23+/s2
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148143
PNG
(US8962611, 3.95)
Show SMILES CO[C@H]1COC[C@@H]1N(C)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1CC1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C27H32ClN7O4/c1-15-4-6-16(7-5-15)12-35-24-19(31-26(35)34(2)21-13-38-14-22(21)37-3)9-20(25-32-27(36)39-33-25)30-23(24)17-8-18(28)11-29-10-17/h8-11,15-16,21-22H,4-7,12-14H2,1-3H3,(H,32,33,36)/t15-,16?,21-,22-/s2
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n/an/a 26n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148144
PNG
(US8962611, 3.97)
Show SMILES CCN(C)C(=O)[C@@H]1CCCN1c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C29H35ClN8O3/c1-4-36(3)27(39)23-6-5-11-37(23)28-33-21-13-22(26-34-29(40)41-35-26)32-24(19-12-20(30)15-31-14-19)25(21)38(28)16-18-9-7-17(2)8-10-18/h12-15,17-18,23H,4-11,16H2,1-3H3,(H,34,35,40)/t17-,18-,23-/s2
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n/an/a 7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135217
PNG
(US8846657, 3.110)
Show SMILES CCCN(CCOC)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C27H34ClN7O3/c1-4-9-34(10-11-37-3)26-31-21-13-22(25-32-27(36)38-33-25)30-23(19-12-20(28)15-29-14-19)24(21)35(26)16-18-7-5-17(2)6-8-18/h12-15,17-18H,4-11,16H2,1-3H3,(H,32,33,36)/t17-,18-
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135219
PNG
(US8846657, 3.112)
Show SMILES CCNC(=O)[C@@H]1CCCN1c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H33ClN8O3/c1-3-31-26(38)22-5-4-10-36(22)27-33-20-12-21(25-34-28(39)40-35-25)32-23(18-11-19(29)14-30-13-18)24(20)37(27)15-17-8-6-16(2)7-9-17/h11-14,16-17,22H,3-10,15H2,1-2H3,(H,31,38)(H,34,35,39)/t16-,17-,22-/s2
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US Patent
n/an/a 50n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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US Patent
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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US Patent
n/an/a 5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135222
PNG
(US8846657, 3.115 | US8846657, 3.116 | US8846657, 3...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-16-4-6-18(7-5-16)15-36-25-22(32-27(36)35-9-8-21(38-3)10-17(35)2)12-23(26-33-28(37)39-34-26)31-24(25)19-11-20(29)14-30-13-19/h11-14,16-18,21H,4-10,15H2,1-3H3,(H,33,34,37)/t16-,17-,18-,21+/s2
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US Patent
n/an/a 18n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148145
PNG
(US8962611, 3.126)
Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CN(CC[C@@H]23)C(=O)OCc2ccccc2)CC1
Show InChI InChI=1/C36H39ClN8O5/c1-22-7-9-23(10-8-22)19-45-32-27(16-28(33-41-35(46)50-42-33)39-31(32)25-15-26(37)18-38-17-25)40-34(45)44-13-14-48-30-20-43(12-11-29(30)44)36(47)49-21-24-5-3-2-4-6-24/h2-6,15-18,22-23,29-30H,7-14,19-21H2,1H3,(H,41,42,46)/t22-,23-,29-,30-/s2
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US Patent
n/an/a 250n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148146
PNG
(US8962611, 3.127)
Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CNCC[C@@H]23)CC1
Show InChI InChI=1/C28H33ClN8O3/c1-16-2-4-17(5-3-16)15-37-25-20(33-27(37)36-8-9-39-23-14-30-7-6-22(23)36)11-21(26-34-28(38)40-35-26)32-24(25)18-10-19(29)13-31-12-18/h10-13,16-17,22-23,30H,2-9,14-15H2,1H3,(H,34,35,38)/t16-,17-,22-,23-/s2
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US Patent
n/an/a 512n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM148147
PNG
(US8962611, 3.128)
Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CN(Cc4ccccc4)CC[C@@H]23)CC1
Show InChI InChI=1/C35H39ClN8O3/c1-22-7-9-24(10-8-22)20-44-32-27(16-28(33-40-35(45)47-41-33)38-31(32)25-15-26(36)18-37-17-25)39-34(44)43-13-14-46-30-21-42(12-11-29(30)43)19-23-5-3-2-4-6-23/h2-6,15-18,22,24,29-30H,7-14,19-21H2,1H3,(H,40,41,45)/t22-,24-,29-,30-/s2
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US Patent
n/an/a 129n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135294
PNG
(US8846657, 4.11 | US8846657, 4.14)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C(C)[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-15-5-7-18(8-6-15)17(3)36-25-22(32-27(36)35-14-21(38-4)9-16(35)2)11-23(26-33-28(37)39-34-26)31-24(25)19-10-20(29)13-30-12-19/h10-13,15-18,21H,5-9,14H2,1-4H3,(H,33,34,37)/t15-,16-,17?,18-,21-/s2
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US Patent
n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135294
PNG
(US8846657, 4.11 | US8846657, 4.14)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C(C)[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C28H34ClN7O3/c1-15-5-7-18(8-6-15)17(3)36-25-22(32-27(36)35-14-21(38-4)9-16(35)2)11-23(26-33-28(37)39-34-26)31-24(25)19-10-20(29)13-30-12-19/h10-13,15-18,21H,5-9,14H2,1-4H3,(H,33,34,37)/t15-,16-,17?,18-,21-/s2
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US Patent
n/an/a 2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135217
PNG
(US8846657, 3.110)
Show SMILES CCCN(CCOC)c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1
Show InChI InChI=1/C27H34ClN7O3/c1-4-9-34(10-11-37-3)26-31-21-13-22(25-32-27(36)38-33-25)30-23(19-12-20(28)15-29-14-19)24(21)35(26)16-18-7-5-17(2)6-8-18/h12-15,17-18H,4-11,16H2,1-3H3,(H,32,33,36)/t17-,18-
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US Patent
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair