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2 similar compounds to monomer 152933

Compile data set for download or QSAR
Wt: 426.4
BDBM152934
Wt: 357.4
BDBM141400

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 152934,141400   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium release-activated calcium channel


(Homo sapiens (Human))
BDBM152934
PNG
(US8993612, 12)
Show SMILES Fc1cc(NC(=O)Cc2ccc3ncccc3c2)ccc1-n1nc(cc1C1CC1)C1CC1
Show InChI InChI=1S/C26H23FN4O/c27-21-14-20(29-26(32)13-16-3-9-22-19(12-16)2-1-11-28-22)8-10-24(21)31-25(18-6-7-18)15-23(30-31)17-4-5-17/h1-3,8-12,14-15,17-18H,4-7,13H2,(H,29,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 263n/an/an/an/an/a37



Rhizen Pharmaceuticals SA

US Patent


Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...


US Patent US8993612 (2015)


BindingDB Entry DOI: 10.7270/Q2CN72NK
More data for this
Ligand-Target Pair
Calcium release-activated calcium (CRAC)


(Homo sapiens (Human))
BDBM141400
PNG
(US8921364, 19)
Show SMILES O=C(Cc1ccccc1)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1
Show InChI InChI=1S/C23H23N3O/c27-23(14-16-4-2-1-3-5-16)24-19-10-12-20(13-11-19)26-22(18-8-9-18)15-21(25-26)17-6-7-17/h1-5,10-13,15,17-18H,6-9,14H2,(H,24,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 457n/an/an/an/an/a37



Rhizen Pharmaceuticals SA

US Patent


Assay Description
Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...


US Patent US8921364 (2014)


BindingDB Entry DOI: 10.7270/Q2N58K3N
More data for this
Ligand-Target Pair