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6 similar compounds to monomer 142750

Compile data set for download or QSAR
Wt: 490.5
BDBM142745
Wt: 570.6
BDBM142751
Wt: 626.7
BDBM142752
Wt: 614.6
BDBM142753
Wt: 642.6
BDBM142754
Wt: 642.6
BDBM142755

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 142745,142751,142752,142753,142754,142755   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142745
PNG
(US8937193, 6a)
Show SMILES CC(C)c1c(O)c(O)cc2c1c(=O)c(C)c(-c1c(C)c(=O)c3c(C(C)C)c(O)c(O)cc3c1=O)c2=O
Show InChI InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,29-30,35-36H,1-6H3
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n/an/a 630n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142754
PNG
(US8937193, 6f)
Show SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1
Show InChI InChI=1S/C40H34O8/c1-19-5-9-23(10-6-19)13-15-25-33-27(17-29(41)37(25)45)39(47)31(21(3)35(33)43)32-22(4)36(44)34-26(16-14-24-11-7-20(2)8-12-24)38(46)30(42)18-28(34)40(32)48/h5-12,17-18,41-42,45-46H,13-16H2,1-4H3
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n/an/an/a 2.50E+3n/an/an/an/an/a



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142751
PNG
(US8937193, 6c)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CC4CCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CC3CCCC3)c2c1=O
Show InChI InChI=1S/C34H34O8/c1-15-25(33(41)21-13-23(35)31(39)19(27(21)29(15)37)11-17-7-3-4-8-17)26-16(2)30(38)28-20(12-18-9-5-6-10-18)32(40)24(36)14-22(28)34(26)42/h13-14,17-18,35-36,39-40H,3-12H2,1-2H3
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n/an/a 2.99E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142752
PNG
(US8937193, 6d)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCC4CCCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCC3CCCCC3)c2c1=O
Show InChI InChI=1S/C38H42O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h17-18,21-22,39-40,43-44H,3-16H2,1-2H3
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n/an/a 1.27E+4n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142753
PNG
(US8937193, 6e)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCc3ccccc3)c2c1=O
Show InChI InChI=1S/C38H30O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h3-12,17-18,39-40,43-44H,13-16H2,1-2H3
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n/an/a 1.79E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142755
PNG
(US8937193, 6g)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCCc3ccccc3)c2c1=O
Show InChI InChI=1S/C40H34O8/c1-21-31(39(47)27-19-29(41)37(45)25(33(27)35(21)43)17-9-15-23-11-5-3-6-12-23)32-22(2)36(44)34-26(18-10-16-24-13-7-4-8-14-24)38(46)30(42)20-28(34)40(32)48/h3-8,11-14,19-20,41-42,45-46H,9-10,15-18H2,1-2H3
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n/an/a 1.44E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142745
PNG
(US8937193, 6a)
Show SMILES CC(C)c1c(O)c(O)cc2c1c(=O)c(C)c(-c1c(C)c(=O)c3c(C(C)C)c(O)c(O)cc3c1=O)c2=O
Show InChI InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,29-30,35-36H,1-6H3
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n/an/a 370n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142754
PNG
(US8937193, 6f)
Show SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1
Show InChI InChI=1S/C40H34O8/c1-19-5-9-23(10-6-19)13-15-25-33-27(17-29(41)37(25)45)39(47)31(21(3)35(33)43)32-22(4)36(44)34-26(16-14-24-11-7-20(2)8-12-24)38(46)30(42)18-28(34)40(32)48/h5-12,17-18,41-42,45-46H,13-16H2,1-4H3
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n/an/a 3.12E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142751
PNG
(US8937193, 6c)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CC4CCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CC3CCCC3)c2c1=O
Show InChI InChI=1S/C34H34O8/c1-15-25(33(41)21-13-23(35)31(39)19(27(21)29(15)37)11-17-7-3-4-8-17)26-16(2)30(38)28-20(12-18-9-5-6-10-18)32(40)24(36)14-22(28)34(26)42/h13-14,17-18,35-36,39-40H,3-12H2,1-2H3
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n/an/a 2.27E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142752
PNG
(US8937193, 6d)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCC4CCCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCC3CCCCC3)c2c1=O
Show InChI InChI=1S/C38H42O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h17-18,21-22,39-40,43-44H,3-16H2,1-2H3
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n/an/a 6.73E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142753
PNG
(US8937193, 6e)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCc3ccccc3)c2c1=O
Show InChI InChI=1S/C38H30O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h3-12,17-18,39-40,43-44H,13-16H2,1-2H3
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US Patent
n/an/a 2.57E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM142755
PNG
(US8937193, 6g)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCCc3ccccc3)c2c1=O
Show InChI InChI=1S/C40H34O8/c1-21-31(39(47)27-19-29(41)37(45)25(33(27)35(21)43)17-9-15-23-11-5-3-6-12-23)32-22(2)36(44)34-26(18-10-16-24-13-7-4-8-14-24)38(46)30(42)20-28(34)40(32)48/h3-8,11-14,19-20,41-42,45-46H,9-10,15-18H2,1-2H3
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n/an/a 2.17E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM142745
PNG
(US8937193, 6a)
Show SMILES CC(C)c1c(O)c(O)cc2c1c(=O)c(C)c(-c1c(C)c(=O)c3c(C(C)C)c(O)c(O)cc3c1=O)c2=O
Show InChI InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,29-30,35-36H,1-6H3
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n/an/a 2.17E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM142754
PNG
(US8937193, 6f)
Show SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1
Show InChI InChI=1S/C40H34O8/c1-19-5-9-23(10-6-19)13-15-25-33-27(17-29(41)37(25)45)39(47)31(21(3)35(33)43)32-22(4)36(44)34-26(16-14-24-11-7-20(2)8-12-24)38(46)30(42)18-28(34)40(32)48/h5-12,17-18,41-42,45-46H,13-16H2,1-4H3
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n/an/a 1.47E+4n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM142753
PNG
(US8937193, 6e)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCc3ccccc3)c2c1=O
Show InChI InChI=1S/C38H30O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h3-12,17-18,39-40,43-44H,13-16H2,1-2H3
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n/an/a 9.72E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM142755
PNG
(US8937193, 6g)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCCc3ccccc3)c2c1=O
Show InChI InChI=1S/C40H34O8/c1-21-31(39(47)27-19-29(41)37(45)25(33(27)35(21)43)17-9-15-23-11-5-3-6-12-23)32-22(2)36(44)34-26(18-10-16-24-13-7-4-8-14-24)38(46)30(42)20-28(34)40(32)48/h3-8,11-14,19-20,41-42,45-46H,9-10,15-18H2,1-2H3
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n/an/a 5.27E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142745
PNG
(US8937193, 6a)
Show SMILES CC(C)c1c(O)c(O)cc2c1c(=O)c(C)c(-c1c(C)c(=O)c3c(C(C)C)c(O)c(O)cc3c1=O)c2=O
Show InChI InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,29-30,35-36H,1-6H3
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n/an/a 540n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142754
PNG
(US8937193, 6f)
Show SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1
Show InChI InChI=1S/C40H34O8/c1-19-5-9-23(10-6-19)13-15-25-33-27(17-29(41)37(25)45)39(47)31(21(3)35(33)43)32-22(4)36(44)34-26(16-14-24-11-7-20(2)8-12-24)38(46)30(42)18-28(34)40(32)48/h5-12,17-18,41-42,45-46H,13-16H2,1-4H3
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US Patent
n/an/a 2.05E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142751
PNG
(US8937193, 6c)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CC4CCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CC3CCCC3)c2c1=O
Show InChI InChI=1S/C34H34O8/c1-15-25(33(41)21-13-23(35)31(39)19(27(21)29(15)37)11-17-7-3-4-8-17)26-16(2)30(38)28-20(12-18-9-5-6-10-18)32(40)24(36)14-22(28)34(26)42/h13-14,17-18,35-36,39-40H,3-12H2,1-2H3
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US Patent
n/an/a 3.08E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142752
PNG
(US8937193, 6d)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCC4CCCCC4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCC3CCCCC3)c2c1=O
Show InChI InChI=1S/C38H42O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h17-18,21-22,39-40,43-44H,3-16H2,1-2H3
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US Patent
n/an/a 5.90E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142753
PNG
(US8937193, 6e)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCc3ccccc3)c2c1=O
Show InChI InChI=1S/C38H30O8/c1-19-29(37(45)25-17-27(39)35(43)23(31(25)33(19)41)15-13-21-9-5-3-6-10-21)30-20(2)34(42)32-24(16-14-22-11-7-4-8-12-22)36(44)28(40)18-26(32)38(30)46/h3-12,17-18,39-40,43-44H,13-16H2,1-2H3
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US Patent
n/an/a 1.29E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM142755
PNG
(US8937193, 6g)
Show SMILES Cc1c(-c2c(C)c(=O)c3c(CCCc4ccccc4)c(O)c(O)cc3c2=O)c(=O)c2cc(O)c(O)c(CCCc3ccccc3)c2c1=O
Show InChI InChI=1S/C40H34O8/c1-21-31(39(47)27-19-29(41)37(45)25(33(27)35(21)43)17-9-15-23-11-5-3-6-12-23)32-22(2)36(44)34-26(18-10-16-24-13-7-4-8-14-24)38(46)30(42)20-28(34)40(32)48/h3-8,11-14,19-20,41-42,45-46H,9-10,15-18H2,1-2H3
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US Patent
n/an/a 670n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142745
PNG
(US8937193, 6a)
Show SMILES CC(C)c1c(O)c(O)cc2c1c(=O)c(C)c(-c1c(C)c(=O)c3c(C(C)C)c(O)c(O)cc3c1=O)c2=O
Show InChI InChI=1S/C28H26O8/c1-9(2)17-21-13(7-15(29)27(17)35)25(33)19(11(5)23(21)31)20-12(6)24(32)22-14(26(20)34)8-16(30)28(36)18(22)10(3)4/h7-10,29-30,35-36H,1-6H3
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US Patent
n/an/an/a 2.80E+3n/an/an/an/an/a



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM142754
PNG
(US8937193, 6f)
Show SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1
Show InChI InChI=1S/C40H34O8/c1-19-5-9-23(10-6-19)13-15-25-33-27(17-29(41)37(25)45)39(47)31(21(3)35(33)43)32-22(4)36(44)34-26(16-14-24-11-7-20(2)8-12-24)38(46)30(42)18-28(34)40(32)48/h5-12,17-18,41-42,45-46H,13-16H2,1-4H3
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US Patent
n/an/a 3.10E+3n/an/an/an/an/a25



Sanford-Burnham Medical Research Institute

US Patent


Assay Description
A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...


US Patent US8937193 (2015)


BindingDB Entry DOI: 10.7270/Q20C4TG4
More data for this
Ligand-Target Pair