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3 similar compounds to monomer 14974

Compile data set for download or QSAR
Wt: 449.4
BDBM14971
Wt: 449.4
BDBM14973
Wt: 532.5
BDBM14976

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14971,14973,14976   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 4n/an/an/an/a7.522



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14973
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-4-5-16(23(33)31-18-8-6-17(7-9-18)24(25,26)27)13-21(15)32-22-19(3-2-11-29-22)20-10-12-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 504n/an/an/an/a7.522



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14976
PNG
(4-Methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O/c1-19-7-8-20(16-24(19)36-27-22(6-5-12-34-27)23-11-13-33-18-35-23)28(39)37-25-17-21(29(30,31)32)9-10-26(25)38-14-3-2-4-15-38/h5-13,16-18H,2-4,14-15H2,1H3,(H,34,36)(H,37,39)
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n/an/a 181n/an/an/an/a7.522



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14973
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-4-5-16(23(33)31-18-8-6-17(7-9-18)24(25,26)27)13-21(15)32-22-19(3-2-11-29-22)20-10-12-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 177n/an/an/an/an/an/a



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 3.60n/an/an/an/an/an/a



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 52: 6189-92 (2009)


Article DOI: 10.1021/jm901081g
BindingDB Entry DOI: 10.7270/Q2TH8K26
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
B-RAF V600E


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 0.460n/a 15n/an/a7.023



Amgen Inc



Assay Description
The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...


J Med Chem 52: 6189-92 (2009)


Article DOI: 10.1021/jm901081g
BindingDB Entry DOI: 10.7270/Q2TH8K26
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 12n/an/an/an/a7.523



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 52: 6189-92 (2009)


Article DOI: 10.1021/jm901081g
BindingDB Entry DOI: 10.7270/Q2TH8K26
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 4.20n/an/an/an/a7.523



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 52: 6189-92 (2009)


Article DOI: 10.1021/jm901081g
BindingDB Entry DOI: 10.7270/Q2TH8K26
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 3.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 52: 6189-92 (2009)


Article DOI: 10.1021/jm901081g
BindingDB Entry DOI: 10.7270/Q2TH8K26
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14976
PNG
(4-Methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O/c1-19-7-8-20(16-24(19)36-27-22(6-5-12-34-27)23-11-13-33-18-35-23)28(39)37-25-17-21(29(30,31)32)9-10-26(25)38-14-3-2-4-15-38/h5-13,16-18H,2-4,14-15H2,1H3,(H,34,36)(H,37,39)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair