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7 similar compounds to monomer 150770

Wt: 336.3
BDBM150768
Wt: 396.4
BDBM150769
Wt: 350.3
BDBM150771
Purchase
Wt: 338.3
BDBM150772
Wt: 335.3
BDBM150773
Wt: 334.3
BDBM150775
Wt: 399.2
BDBM150778

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 150768,150769,150771,150772,150773,150775,150778   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150768
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-h...)
Show SMILES Oc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H12N4O2S/c22-11-5-3-4-10(8-11)14(23)9-24-17-19-16-15(20-21-17)12-6-1-2-7-13(12)18-16/h1-8,22H,9H2,(H,18,19,21)
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n/an/a 2.46E+3n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150769
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(bip...)
Show SMILES O=C(CSc1nnc2c(n1)[nH]c1ccccc21)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H16N4OS/c28-20(17-12-10-16(11-13-17)15-6-2-1-3-7-15)14-29-23-25-22-21(26-27-23)18-8-4-5-9-19(18)24-22/h1-13H,14H2,(H,24,25,27)
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n/an/a 7.84E+4n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150771
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-m...)
Show SMILES COc1ccc(cc1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C18H14N4O2S/c1-24-12-8-6-11(7-9-12)15(23)10-25-18-20-17-16(21-22-18)13-4-2-3-5-14(13)19-17/h2-9H,10H2,1H3,(H,19,20,22)
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PubMed
n/an/a 2.89E+4n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150778
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-b...)
Show SMILES Brc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11BrN4OS/c18-11-5-3-4-10(8-11)14(23)9-24-17-20-16-15(21-22-17)12-6-1-2-7-13(12)19-16/h1-8H,9H2,(H,19,20,22)
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n/an/a 3.71E+4n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150773
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-n...)
Show SMILES Nc1ccc(cc1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H13N5OS/c18-11-7-5-10(6-8-11)14(23)9-24-17-20-16-15(21-22-17)12-3-1-2-4-13(12)19-16/h1-8H,9,18H2,(H,19,20,22)
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PubMed
n/an/a 1.25E+5n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150775
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-phen...)
Show SMILES CC(Sc1nnc2c(n1)[nH]c1ccccc21)C(=O)c1ccccc1
Show InChI InChI=1/C18H14N4OS/c1-11(16(23)12-7-3-2-4-8-12)24-18-20-17-15(21-22-18)13-9-5-6-10-14(13)19-17/h2-11H,1H3,(H,19,20,22)
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PubMed
n/an/a 3.69E+4n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM150772
PNG
(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(3-f...)
Show SMILES Fc1cccc(c1)C(=O)CSc1nnc2c(n1)[nH]c1ccccc21
Show InChI InChI=1S/C17H11FN4OS/c18-11-5-3-4-10(8-11)14(23)9-24-17-20-16-15(21-22-17)12-6-1-2-7-13(12)19-16/h1-8H,9H2,(H,19,20,22)
PDB
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Article
PubMed
n/an/a 3.81E+4n/an/an/an/an/a310.15



Hazara University



Assay Description
Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...


Bioorg Chem 58: 81-7 (2015)

More data for this
Ligand-Target Pair