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129 similar compounds to monomer 151304

Compile data set for download or QSAR
Wt: 548.6
BDBM151214
Wt: 616.6
BDBM151215
Wt: 586.7
BDBM151248
Wt: 660.6
BDBM151249
Wt: 622.6
BDBM151250
Wt: 554.6
BDBM151253
Wt: 538.6
BDBM151229
Wt: 540.6
BDBM151244
Wt: 578.6
BDBM151245
Wt: 578.7
BDBM151247
Wt: 552.6
BDBM151222
Wt: 578.7
BDBM151223
Wt: 601.1
BDBM151236
Wt: 554.6
BDBM151239
Wt: 672.6
BDBM151269
Displayed 1 to 15 (of 129 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 151214,151215,151248,151249,151250,151253,151229,151244,151245,151247,151222,151223,151236,151239,151269   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM151214
PNG
(US8987314, B5)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(F)nc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C23H21FN4O5S3/c24-20-9-7-17(13-27-20)16-6-8-18-19(12-16)34-23(28-18)21(22(29)26-10-11-36(25,32)33)35(30,31)14-15-4-2-1-3-5-15/h1-9,12-13,21H,10-11,14H2,(H,26,29)(H2,25,32,33)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151269
PNG
(US8987314, B65)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C27H24F4N4O6S3/c28-20-8-1-16(2-9-20)14-43(38,39)23(25(37)33-11-12-44(32,40)41)26-35-21-10-7-19(13-22(21)42-26)17-3-5-18(6-4-17)24(36)34-15-27(29,30)31/h1-10,13,23H,11-12,14-15H2,(H,33,37)(H,34,36)(H2,32,40,41)
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n/an/a 61n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151222
PNG
(US8987314, B13)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H28N4O6S3/c1-35(29,30)21(22(28)25-8-13-36(24,31)32)23-26-19-7-6-18(14-20(19)34-23)17-4-2-16(3-5-17)15-27-9-11-33-12-10-27/h2-7,14,21H,8-13,15H2,1H3,(H,25,28)(H2,24,31,32)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151223
PNG
(US8987314, B14)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(CN2CCOCC2)cc1)S(=O)(=O)CC=C
Show InChI InChI=1S/C25H30N4O6S3/c1-2-14-37(31,32)23(24(30)27-9-15-38(26,33)34)25-28-21-8-7-20(16-22(21)36-25)19-5-3-18(4-6-19)17-29-10-12-35-13-11-29/h2-8,16,23H,1,9-15,17H2,(H,27,30)(H2,26,33,34)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151229
PNG
(US8987314, B20)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C22H26N4O6S3/c1-34(28,29)20(21(27)24-8-13-35(23,30)31)22-25-18-7-4-16(14-19(18)33-22)15-2-5-17(6-3-15)26-9-11-32-12-10-26/h2-7,14,20H,8-13H2,1H3,(H,24,27)(H2,23,30,31)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151236
PNG
(US8987314, B32)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C23H25ClN4O7S3/c1-37(31,32)20(21(29)26-6-11-38(25,33)34)22-27-18-5-3-15(13-19(18)36-22)14-2-4-16(17(24)12-14)23(30)28-7-9-35-10-8-28/h2-5,12-13,20H,6-11H2,1H3,(H,26,29)(H2,25,33,34)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151239
PNG
(US8987314, B35)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O7S3/c1-33-11-9-24-20(27)15-5-3-14(4-6-15)16-7-8-17-18(13-16)34-22(26-17)19(35(2,29)30)21(28)25-10-12-36(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151244
PNG
(US8987314, B40)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C21H24N4O7S3/c1-34(29,30)18(20(28)24-9-11-35(22,31)32)21-25-16-7-6-15(12-17(16)33-21)13-2-4-14(5-3-13)19(27)23-8-10-26/h2-7,12,18,26H,8-11H2,1H3,(H,23,27)(H,24,28)(H2,22,31,32)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151245
PNG
(US8987314, B41)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H21F3N4O6S3/c1-36(31,32)17(19(30)26-8-9-37(25,33)34)20-28-15-7-6-14(10-16(15)35-20)12-2-4-13(5-3-12)18(29)27-11-21(22,23)24/h2-7,10,17H,8-9,11H2,1H3,(H,26,30)(H,27,29)(H2,25,33,34)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151247
PNG
(US8987314, B43)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C25H30N4O6S3/c1-16-9-12-29(13-10-16)25(31)18-5-3-17(4-6-18)19-7-8-20-21(15-19)36-24(28-20)22(37(2,32)33)23(30)27-11-14-38(26,34)35/h3-8,15-16,22H,9-14H2,1-2H3,(H,27,30)(H2,26,34,35)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151248
PNG
(US8987314, B44)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H26N4O6S3/c1-17(31)29-21-10-7-19(8-11-21)20-9-12-22-23(15-20)37-26(30-22)24(25(32)28-13-14-39(27,35)36)38(33,34)16-18-5-3-2-4-6-18/h2-12,15,24H,13-14,16H2,1H3,(H,28,32)(H,29,31)(H2,27,35,36)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151249
PNG
(US8987314, B45)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C23H22F6N4O6S3/c24-22(25,26)7-9-41(36,37)18(20(35)31-8-10-42(30,38)39)21-33-16-6-5-15(11-17(16)40-21)13-1-3-14(4-2-13)19(34)32-12-23(27,28)29/h1-6,11,18H,7-10,12H2,(H,31,35)(H,32,34)(H2,30,38,39)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151250
PNG
(US8987314, B46)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCCO)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C23H25F3N4O7S3/c24-23(25,26)7-11-39(34,35)19(21(33)29-9-12-40(27,36)37)22-30-17-6-5-16(13-18(17)38-22)14-1-3-15(4-2-14)20(32)28-8-10-31/h1-6,13,19,31H,7-12H2,(H,28,32)(H,29,33)(H2,27,36,37)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151253
PNG
(US8987314, B49)
Show SMILES COCCNC(=O)c1cccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O7S3/c1-33-10-8-24-20(27)16-5-3-4-14(12-16)15-6-7-17-18(13-15)34-22(26-17)19(35(2,29)30)21(28)25-9-11-36(23,31)32/h3-7,12-13,19H,8-11H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151269
PNG
(US8987314, B65)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C27H24F4N4O6S3/c28-20-8-1-16(2-9-20)14-43(38,39)23(25(37)33-11-12-44(32,40)41)26-35-21-10-7-19(13-22(21)42-26)17-3-5-18(6-4-17)24(36)34-15-27(29,30)31/h1-10,13,23H,11-12,14-15H2,(H,33,37)(H,34,36)(H2,32,40,41)
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n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151236
PNG
(US8987314, B32)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C23H25ClN4O7S3/c1-37(31,32)20(21(29)26-6-11-38(25,33)34)22-27-18-5-3-15(13-19(18)36-22)14-2-4-16(17(24)12-14)23(30)28-7-9-35-10-8-28/h2-5,12-13,20H,6-11H2,1H3,(H,26,29)(H2,25,33,34)
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n/an/a 923n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151239
PNG
(US8987314, B35)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O7S3/c1-33-11-9-24-20(27)15-5-3-14(4-6-15)16-7-8-17-18(13-16)34-22(26-17)19(35(2,29)30)21(28)25-10-12-36(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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n/an/a 43n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151244
PNG
(US8987314, B40)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C21H24N4O7S3/c1-34(29,30)18(20(28)24-9-11-35(22,31)32)21-25-16-7-6-15(12-17(16)33-21)13-2-4-14(5-3-13)19(27)23-8-10-26/h2-7,12,18,26H,8-11H2,1H3,(H,23,27)(H,24,28)(H2,22,31,32)
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n/an/a 19n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151245
PNG
(US8987314, B41)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H21F3N4O6S3/c1-36(31,32)17(19(30)26-8-9-37(25,33)34)20-28-15-7-6-14(10-16(15)35-20)12-2-4-13(5-3-12)18(29)27-11-21(22,23)24/h2-7,10,17H,8-9,11H2,1H3,(H,26,30)(H,27,29)(H2,25,33,34)
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US Patent
n/an/a 17n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151247
PNG
(US8987314, B43)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C25H30N4O6S3/c1-16-9-12-29(13-10-16)25(31)18-5-3-17(4-6-18)19-7-8-20-21(15-19)36-24(28-20)22(37(2,32)33)23(30)27-11-14-38(26,34)35/h3-8,15-16,22H,9-14H2,1-2H3,(H,27,30)(H2,26,34,35)
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US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151248
PNG
(US8987314, B44)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H26N4O6S3/c1-17(31)29-21-10-7-19(8-11-21)20-9-12-22-23(15-20)37-26(30-22)24(25(32)28-13-14-39(27,35)36)38(33,34)16-18-5-3-2-4-6-18/h2-12,15,24H,13-14,16H2,1H3,(H,28,32)(H,29,31)(H2,27,35,36)
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n/an/a 148n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151249
PNG
(US8987314, B45)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCC(F)(F)F)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C23H22F6N4O6S3/c24-22(25,26)7-9-41(36,37)18(20(35)31-8-10-42(30,38)39)21-33-16-6-5-15(11-17(16)40-21)13-1-3-14(4-2-13)19(34)32-12-23(27,28)29/h1-6,11,18H,7-10,12H2,(H,31,35)(H,32,34)(H2,30,38,39)
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n/an/a 38n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151250
PNG
(US8987314, B46)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCCO)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C23H25F3N4O7S3/c24-23(25,26)7-11-39(34,35)19(21(33)29-9-12-40(27,36)37)22-30-17-6-5-16(13-18(17)38-22)14-1-3-15(4-2-14)20(32)28-8-10-31/h1-6,13,19,31H,7-12H2,(H,28,32)(H,29,33)(H2,27,36,37)
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n/an/a 520n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151253
PNG
(US8987314, B49)
Show SMILES COCCNC(=O)c1cccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O7S3/c1-33-10-8-24-20(27)16-5-3-4-14(12-16)15-6-7-17-18(13-15)34-22(26-17)19(35(2,29)30)21(28)25-9-11-36(23,31)32/h3-7,12-13,19H,8-11H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
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US Patent
n/an/a 152n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151215
PNG
(US8987314, B6)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(F)nc1)S(=O)(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H20F4N4O5S3/c25-20-8-4-16(12-31-20)15-3-7-18-19(11-15)38-23(32-18)21(22(33)30-9-10-40(29,36)37)39(34,35)13-14-1-5-17(6-2-14)24(26,27)28/h1-8,11-12,21H,9-10,13H2,(H,30,33)(H2,29,36,37)
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US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Co.

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair