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13 similar compounds to monomer 15152

Compile data set for download or QSAR
Wt: 583.6
BDBM15157
Wt: 533.6
BDBM15158
Wt: 533.6
BDBM15159
Wt: 533.6
BDBM15160
Wt: 533.6
BDBM15161
Wt: 511.6
BDBM15149
Wt: 477.5
BDBM15150
Wt: 477.5
BDBM15151
Wt: 491.5
BDBM15153
Wt: 567.6
BDBM15154
Wt: 567.6
BDBM15155
Wt: 583.6
BDBM15156
Wt: 519.6
BDBM50298450

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 15157,15158,15159,15160,15161,15149,15150,15151,15153,15154,15155,15156,50298450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15160
PNG
(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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325n/an/an/an/an/an/an/an/a



University of California-San Francisco

Curated by ChEMBL


Assay Description
Inhibition of Akt2


Chem Biol 12: 621-37 (2005)


Article DOI: 10.1016/j.chembiol.2005.04.011
BindingDB Entry DOI: 10.7270/Q2R49RR6
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15151
PNG
(1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)cnc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(21-6-2-1-3-7-21)28(32-26)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a 1.50E+3n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15153
PNG
(1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)
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n/an/a 1.00E+3n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15154
PNG
(1-(1-{[4-(6-benzyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc(Cc3ccccc3)c(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(34(39-35)27-11-5-2-6-12-27)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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n/an/a 1.70E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15155
PNG
(1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)c(Cc3ccccc3)nc2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(27-11-5-2-6-12-27)34(39-35)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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n/an/a>5.00E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15156
PNG
(1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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n/an/a 2.17E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15157
PNG
(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(33(37-31)26-6-2-1-3-7-26)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15158
PNG
(1-[1-({4-[6-(butan-2-yl)-5-oxo-3-phenyl-4,5-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(24-9-5-4-6-10-24)30(35-29)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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n/an/a 1.70E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15159
PNG
(1-[1-({4-[5-(butan-2-yl)-6-oxo-3-phenyl-1,6-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(30(35-29)24-9-5-4-6-10-24)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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n/an/a>5.00E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15160
PNG
(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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n/an/a>5.00E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15161
PNG
(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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n/an/a 2.12E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15150
PNG
(1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a 1.57E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15151
PNG
(1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)cnc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(21-6-2-1-3-7-21)28(32-26)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15153
PNG
(1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)
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n/an/a 1.18E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15154
PNG
(1-(1-{[4-(6-benzyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc(Cc3ccccc3)c(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(34(39-35)27-11-5-2-6-12-27)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15155
PNG
(1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)c(Cc3ccccc3)nc2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(27-11-5-2-6-12-27)34(39-35)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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n/an/a 1.76E+3n/an/an/an/an/an/a



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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15156
PNG
(1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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n/an/a 4.53E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15157
PNG
(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(33(37-31)26-6-2-1-3-7-26)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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n/an/a 5.41E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15158
PNG
(1-[1-({4-[6-(butan-2-yl)-5-oxo-3-phenyl-4,5-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(24-9-5-4-6-10-24)30(35-29)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15159
PNG
(1-[1-({4-[5-(butan-2-yl)-6-oxo-3-phenyl-1,6-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(30(35-29)24-9-5-4-6-10-24)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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n/an/a 4.52E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15160
PNG
(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15161
PNG
(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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n/an/a 325n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a>5.00E+4n/an/an/an/an/an/a



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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15150
PNG
(1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15151
PNG
(1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)cnc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(21-6-2-1-3-7-21)28(32-26)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15153
PNG
(1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)
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n/an/a 3.31E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15154
PNG
(1-(1-{[4-(6-benzyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc(Cc3ccccc3)c(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(34(39-35)27-11-5-2-6-12-27)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15155
PNG
(1-(1-{[4-(5-benzyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)c(Cc3ccccc3)nc2-c2ccccc2)CC1
Show InChI InChI=1S/C36H33N5O2/c42-35-31(23-25-9-3-1-4-10-25)37-33(27-11-5-2-6-12-27)34(39-35)28-17-15-26(16-18-28)24-40-21-19-29(20-22-40)41-32-14-8-7-13-30(32)38-36(41)43/h1-18,29H,19-24H2,(H,38,43)(H,39,42)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15156
PNG
(1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15157
PNG
(1-{1-[(4-{5-[(4-hydroxyphenyl)methyl]-6-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccccc3)c([nH]c2=O)-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(33(37-31)26-6-2-1-3-7-26)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15158
PNG
(1-[1-({4-[6-(butan-2-yl)-5-oxo-3-phenyl-4,5-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(24-9-5-4-6-10-24)30(35-29)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15159
PNG
(1-[1-({4-[5-(butan-2-yl)-6-oxo-3-phenyl-1,6-dihydr...)
Show SMILES CCC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-3-22(2)29-32(39)36-31(30(35-29)24-9-5-4-6-10-24)25-15-13-23(14-16-25)21-37-19-17-26(18-20-37)38-28-12-8-7-11-27(28)34-33(38)40/h4-16,22,26H,3,17-21H2,1-2H3,(H,34,40)(H,36,39)
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Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15160
PNG
(1-[1-({4-[6-(2-methylpropyl)-5-oxo-3-phenyl-4,5-di...)
Show SMILES CC(C)Cc1nc(-c2ccc(CN3CCC(CC3)n3c4ccccc4[nH]c3=O)cc2)c([nH]c1=O)-c1ccccc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(24-8-4-3-5-9-24)30(34-28)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15161
PNG
(1-[1-({4-[5-(2-methylpropyl)-6-oxo-3-phenyl-1,6-di...)
Show SMILES CC(C)Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C33H35N5O2/c1-22(2)20-28-32(39)36-31(30(34-28)24-8-4-3-5-9-24)25-14-12-23(13-15-25)21-37-18-16-26(17-19-37)38-29-11-7-6-10-27(29)35-33(38)40/h3-15,22,26H,16-21H2,1-2H3,(H,35,40)(H,36,39)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 290n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15151
PNG
(1-(1-{[4-(6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2[nH]c(=O)cnc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(21-6-2-1-3-7-21)28(32-26)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15153
PNG
(1-(1-{[4-(5-methyl-6-oxo-3-phenyl-1,6-dihydropyraz...)
Show SMILES Cc1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C30H29N5O2/c1-20-29(36)33-28(27(31-20)22-7-3-2-4-8-22)23-13-11-21(12-14-23)19-34-17-15-24(16-18-34)35-26-10-6-5-9-25(26)32-30(35)37/h2-14,24H,15-19H2,1H3,(H,32,37)(H,33,36)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50298450
PNG
(1-(1-(4-(5-isopropyl-6-oxo-3-phenyl-1,6-dihydropyr...)
Show SMILES CC(C)c1nc(-c2ccccc2)c([nH]c1=O)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1
Show InChI InChI=1S/C32H33N5O2/c1-21(2)28-31(38)35-30(29(34-28)23-8-4-3-5-9-23)24-14-12-22(13-15-24)20-36-18-16-25(17-19-36)37-27-11-7-6-10-26(27)33-32(37)39/h3-15,21,25H,16-20H2,1-2H3,(H,33,39)(H,35,38)
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n/an/a 2.12E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15150
PNG
(1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a 3.03E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15156
PNG
(1-{1-[(4-{6-[(4-hydroxyphenyl)methyl]-5-oxo-3-phen...)
Show SMILES Oc1ccc(Cc2nc(-c3ccc(CN4CCC(CC4)n4c5ccccc5[nH]c4=O)cc3)c([nH]c2=O)-c2ccccc2)cc1
Show InChI InChI=1S/C36H33N5O3/c42-29-16-12-24(13-17-29)22-31-35(43)39-34(26-6-2-1-3-7-26)33(37-31)27-14-10-25(11-15-27)23-40-20-18-28(19-21-40)41-32-9-5-4-8-30(32)38-36(41)44/h1-17,28,42H,18-23H2,(H,38,44)(H,39,43)
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n/an/a 2.17E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Akt3


Bioorg Med Chem Lett 18: 3178-82 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.074
BindingDB Entry DOI: 10.7270/Q20V8DNR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 295n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Akt1


Bioorg Med Chem Lett 18: 3178-82 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.074
BindingDB Entry DOI: 10.7270/Q20V8DNR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 2.06E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Akt2


Bioorg Med Chem Lett 18: 3178-82 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.074
BindingDB Entry DOI: 10.7270/Q20V8DNR
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15149
PNG
(1-(1-{[4-(3-phenylquinoxalin-2-yl)phenyl]methyl}pi...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3ccccc3nc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O/c39-33-36-29-12-6-7-13-30(29)38(33)26-18-20-37(21-19-26)22-23-14-16-25(17-15-23)32-31(24-8-2-1-3-9-24)34-27-10-4-5-11-28(27)35-32/h1-17,26H,18-22H2,(H,36,39)
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n/an/a 290n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15150
PNG
(1-(1-{[4-(5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)p...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2ncc(=O)[nH]c2-c2ccccc2)CC1
Show InChI InChI=1S/C29H27N5O2/c35-26-18-30-27(28(32-26)21-6-2-1-3-7-21)22-12-10-20(11-13-22)19-33-16-14-23(15-17-33)34-25-9-5-4-8-24(25)31-29(34)36/h1-13,18,23H,14-17,19H2,(H,31,36)(H,32,35)
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n/an/a 3.03E+3n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...


Bioorg Med Chem Lett 15: 761-4 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.011
BindingDB Entry DOI: 10.7270/Q2TX3CM4
More data for this
Ligand-Target Pair