Compounds in cluster

3 similar compounds to monomer 15210

Wt: 277.3
BDBM15203

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Wt: 251.3
BDBM50011236

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Wt: 293.3
BDBM50216680

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 15203,50011236,50216680
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase kinase 2 (Homo sapiens (Human))	BDBM50216680 (1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine \|...) Show SMILES NC(N)=NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of CaM-KKbeta				Proc Natl Acad Sci U S A 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM15203 (5-(piperazine-1-sulfonyl)isoquinoline \| CHEMBL7577...) Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]-AB-MECA 21680 radioligand.				J Med Chem 39: 2293-301 (1996) Article DOI: 10.1021/jm950923i BindingDB Entry DOI: 10.7270/Q2D799J2
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Homo sapiens (Human))	BDBM50216680 (1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine \|...) Show SMILES NC(N)=NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Binding affinity at MLCK				Proc Natl Acad Sci U S A 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
cAMP-dependent protein kinase type I-alpha regulatory subunit (Bos taurus)	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase II inhibitor 2 (Bos taurus (Bovine))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (Plasmodium falciparum)	BDBM50216680 (1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine \|...) Show SMILES NC(N)=NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	UniProtKB/TrEMBL GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Pfmrk				Bioorg Med Chem Lett 17: 4961-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.032 BindingDB Entry DOI: 10.7270/Q2GX4CC8
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (Plasmodium falciparum)	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Pfmrk				Bioorg Med Chem Lett 17: 4961-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.032 BindingDB Entry DOI: 10.7270/Q2GX4CC8
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (Plasmodium falciparum)	BDBM15203 (5-(piperazine-1-sulfonyl)isoquinoline \| CHEMBL7577...) Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12 Show InChI	UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Pfmrk				Bioorg Med Chem Lett 17: 4961-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.032 BindingDB Entry DOI: 10.7270/Q2GX4CC8
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50216680 (1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine \|...) Show SMILES NC(N)=NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of ERK2				Proc Natl Acad Sci U S A 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of cAMP-dependent protein kinase (PKA).				J Med Chem 34: 73-8 (1991) Article DOI: 10.1021/jm00105a012 BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of protein kinase C (PKC)				J Med Chem 34: 73-8 (1991) Article DOI: 10.1021/jm00105a012 BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM15203 (5-(piperazine-1-sulfonyl)isoquinoline \| CHEMBL7577...) Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of protein kinase C (PKC)				J Med Chem 34: 73-8 (1991) Article DOI: 10.1021/jm00105a012 BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit gamma (Homo sapiens (Human))	BDBM15203 (5-(piperazine-1-sulfonyl)isoquinoline \| CHEMBL7577...) Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
URA CNRS 1309 Curated by ChEMBL					Assay Description Inhibition of cAMP-dependent protein kinase (PKA).				J Med Chem 34: 73-8 (1991) Article DOI: 10.1021/jm00105a012 BindingDB Entry DOI: 10.7270/Q2J38VS9
URA CNRS 1309 Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15203 (5-(piperazine-1-sulfonyl)isoquinoline \| CHEMBL7577...) Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	7.2	22
UK Centre for Cancer Therapeutics					Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...				Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2
UK Centre for Cancer Therapeutics					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM50011236 (CHEMBL344314 \| Isoquinoline-5-sulfonic acid (2-ami...) Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
Nagoya University School of Medicine					More data for this Ligand-Target Pair