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45 similar compounds to monomer 152924

Wt: 403.4
BDBM152845
Wt: 432.5
BDBM152821
Wt: 432.5
BDBM152822
Wt: 451.9
BDBM152823
Wt: 451.9
BDBM152824
Wt: 488.6
BDBM152825
Wt: 446.5
BDBM152888
Wt: 432.5
BDBM152878
Wt: 447.5
BDBM152870
Wt: 432.5
BDBM152879
Wt: 432.5
BDBM152890
Wt: 446.5
BDBM152891
Wt: 421.4
BDBM152881
Wt: 432.5
BDBM152860
Wt: 417.5
BDBM152883
Displayed 1 to 15 (of 45 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 152845,152821,152822,152823,152824,152825,152888,152878,152870,152879,152890,152891,152881,152860,152883   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152845
PNG
(US8993586, 23)
Show SMILES CC(C)n1ncc2CC3(CCN(CC3)C(=O)c3ccc4ccncc4c3)NC(=O)c12
Show InChI InChI=1S/C23H25N5O2/c1-15(2)28-20-19(14-25-28)12-23(26-21(20)29)6-9-27(10-7-23)22(30)17-4-3-16-5-8-24-13-18(16)11-17/h3-5,8,11,13-15H,6-7,9-10,12H2,1-2H3,(H,26,29)
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US Patent
n/an/a 621n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152825
PNG
(US8993586, 123)
Show SMILES CC(C)(C)Nc1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C28H36N6O2/c1-26(2,3)30-23-21-15-19(8-7-18(21)9-12-29-23)25(36)33-13-10-28(11-14-33)16-20-17-34(27(4,5)6)32-22(20)24(35)31-28/h7-9,12,15,17H,10-11,13-14,16H2,1-6H3,(H,29,30)(H,31,35)
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n/an/a 6.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152870
PNG
(US8993586, 48)
Show SMILES COc1ccc2ncc(cc2c1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H29N5O3/c1-24(2,3)30-15-18-13-25(27-22(31)21(18)28-30)7-9-29(10-8-25)23(32)17-11-16-12-19(33-4)5-6-20(16)26-14-17/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,27,31)
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n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 149n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 123n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152881
PNG
(US8993586, 61)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4[nH]nc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-21(2,3)29-12-14-11-22(24-19(30)17(14)27-29)6-8-28(9-7-22)20(31)13-4-5-16-15(10-13)18(23)26-25-16/h4-5,10,12H,6-9,11H2,1-3H3,(H,24,30)(H3,23,25,26)
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n/an/a 94n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 160n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 185n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 62n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 160n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 73n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152824
PNG
(US8993586, 104)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(Cl)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H,27,31)
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n/an/a 89n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152825
PNG
(US8993586, 123)
Show SMILES CC(C)(C)Nc1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C28H36N6O2/c1-26(2,3)30-23-21-15-19(8-7-18(21)9-12-29-23)25(36)33-13-10-28(11-14-33)16-20-17-34(27(4,5)6)32-22(20)24(35)31-28/h7-9,12,15,17H,10-11,13-14,16H2,1-6H3,(H,29,30)(H,31,35)
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n/an/a 78n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152845
PNG
(US8993586, 23)
Show SMILES CC(C)n1ncc2CC3(CCN(CC3)C(=O)c3ccc4ccncc4c3)NC(=O)c12
Show InChI InChI=1S/C23H25N5O2/c1-15(2)28-20-19(14-25-28)12-23(26-21(20)29)6-9-27(10-7-23)22(30)17-4-3-16-5-8-24-13-18(16)11-17/h3-5,8,11,13-15H,6-7,9-10,12H2,1-2H3,(H,26,29)
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n/an/a 520n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152860
PNG
(US8993586, 38)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)N2
Show InChI InChI=1S/C24H28N6O2/c1-15(2)30-21-19(14-27-30)12-24(28-22(21)31)6-8-29(9-7-24)23(32)17-5-4-16-11-20(25-3)26-13-18(16)10-17/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,25,26)(H,28,31)
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n/an/a 107n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152870
PNG
(US8993586, 48)
Show SMILES COc1ccc2ncc(cc2c1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H29N5O3/c1-24(2,3)30-15-18-13-25(27-22(31)21(18)28-30)7-9-29(10-8-25)23(32)17-11-16-12-19(33-4)5-6-20(16)26-14-17/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,27,31)
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n/an/a 9.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152881
PNG
(US8993586, 61)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4[nH]nc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C22H27N7O2/c1-21(2,3)29-12-14-11-22(24-19(30)17(14)27-29)6-8-28(9-7-22)20(31)13-4-5-16-15(10-13)18(23)26-25-16/h4-5,10,12H,6-9,11H2,1-3H3,(H,24,30)(H3,23,25,26)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 5.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152824
PNG
(US8993586, 104)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(Cl)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H,27,31)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152860
PNG
(US8993586, 38)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)N2
Show InChI InChI=1S/C24H28N6O2/c1-15(2)30-21-19(14-27-30)12-24(28-22(21)31)6-8-29(9-7-24)23(32)17-5-4-16-11-20(25-3)26-13-18(16)10-17/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,25,26)(H,28,31)
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n/an/a 364n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


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Ligand-Target Pair