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36 similar compounds to monomer 152918

Wt: 432.5
BDBM152821
Wt: 432.5
BDBM152822
Wt: 451.9
BDBM152823
Wt: 488.6
BDBM152825
Wt: 446.5
BDBM152888
Wt: 432.5
BDBM152878
Wt: 432.5
BDBM152879
Wt: 432.5
BDBM152890
Wt: 446.5
BDBM152891
Wt: 432.5
BDBM152860
Wt: 417.5
BDBM152883
Wt: 474.5
BDBM152920
Wt: 486.6
BDBM152921
Wt: 488.5
BDBM152925
Wt: 432.5
BDBM152906
Displayed 1 to 15 (of 36 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 152821,152822,152823,152825,152888,152878,152879,152890,152891,152860,152883,152920,152921,152925,152906   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152860
PNG
(US8993586, 38)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)N2
Show InChI InChI=1S/C24H28N6O2/c1-15(2)30-21-19(14-27-30)12-24(28-22(21)31)6-8-29(9-7-24)23(32)17-5-4-16-11-20(25-3)26-13-18(16)10-17/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,25,26)(H,28,31)
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n/an/a 364n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152825
PNG
(US8993586, 123)
Show SMILES CC(C)(C)Nc1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C28H36N6O2/c1-26(2,3)30-23-21-15-19(8-7-18(21)9-12-29-23)25(36)33-13-10-28(11-14-33)16-20-17-34(27(4,5)6)32-22(20)24(35)31-28/h7-9,12,15,17H,10-11,13-14,16H2,1-6H3,(H,29,30)(H,31,35)
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n/an/a 6.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 123n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 160n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 185n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152906
PNG
(US8993586, 94)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cc(N)ncc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)16-5-4-15-11-19(25)26-13-17(15)10-16/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 130n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 62n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 160n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 73n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152920
PNG
(US8993586, 117)
Show SMILES CCN(C)c1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C27H34N6O2/c1-6-31(5)23-21-15-19(8-7-18(21)9-12-28-23)25(35)32-13-10-27(11-14-32)16-20-17-33(26(2,3)4)30-22(20)24(34)29-27/h7-9,12,15,17H,6,10-11,13-14,16H2,1-5H3,(H,29,34)
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n/an/a 332n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152921
PNG
(US8993586, 118)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(NC5CCC5)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C28H34N6O2/c1-27(2,3)34-17-20-16-28(31-25(35)23(20)32-34)10-13-33(14-11-28)26(36)19-8-7-18-9-12-29-24(22(18)15-19)30-21-5-4-6-21/h7-9,12,15,17,21H,4-6,10-11,13-14,16H2,1-3H3,(H,29,30)(H,31,35)
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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152925
PNG
(US8993586, 122)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(NC5COC5)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C27H32N6O3/c1-26(2,3)33-14-19-13-27(30-24(34)22(19)31-33)7-10-32(11-8-27)25(35)18-5-4-17-6-9-28-23(21(17)12-18)29-20-15-36-16-20/h4-6,9,12,14,20H,7-8,10-11,13,15-16H2,1-3H3,(H,28,29)(H,30,34)
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n/an/a 494n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152825
PNG
(US8993586, 123)
Show SMILES CC(C)(C)Nc1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C28H36N6O2/c1-26(2,3)30-23-21-15-19(8-7-18(21)9-12-29-23)25(36)33-13-10-28(11-14-33)16-20-17-34(27(4,5)6)32-22(20)24(35)31-28/h7-9,12,15,17H,10-11,13-14,16H2,1-6H3,(H,29,30)(H,31,35)
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n/an/a 78n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152860
PNG
(US8993586, 38)
Show SMILES CNc1cc2ccc(cc2cn1)C(=O)N1CCC2(CC1)Cc1cnn(C(C)C)c1C(=O)N2
Show InChI InChI=1S/C24H28N6O2/c1-15(2)30-21-19(14-27-30)12-24(28-22(21)31)6-8-29(9-7-24)23(32)17-5-4-16-11-20(25-3)26-13-18(16)10-17/h4-5,10-11,13-15H,6-9,12H2,1-3H3,(H,25,26)(H,28,31)
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n/an/a 107n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152879
PNG
(US8993586, 59)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cnc(N)cc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)15-4-5-16-13-26-19(25)11-17(16)10-15/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152883
PNG
(US8993586, 63)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ncccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H27N5O2/c1-23(2,3)29-15-18-14-24(26-21(30)20(18)27-29)8-11-28(12-9-24)22(31)17-6-7-19-16(13-17)5-4-10-25-19/h4-7,10,13,15H,8-9,11-12,14H2,1-3H3,(H,26,30)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152888
PNG
(US8993586, 69)
Show SMILES CNc1ccc2cc(ccc2n1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-18-14-25(28-22(32)21(18)29-31)9-11-30(12-10-25)23(33)17-5-7-19-16(13-17)6-8-20(26-4)27-19/h5-8,13,15H,9-12,14H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152890
PNG
(US8993586, 72)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccc(N)nc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-5-4-15-6-7-19(25)26-18(15)12-16/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 5.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152891
PNG
(US8993586, 73)
Show SMILES CNc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C25H30N6O2/c1-24(2,3)31-15-19-13-25(28-22(32)21(19)29-31)7-9-30(10-8-25)23(33)16-5-6-17-14-27-20(26-4)12-18(17)11-16/h5-6,11-12,14-15H,7-10,13H2,1-4H3,(H,26,27)(H,28,32)
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152906
PNG
(US8993586, 94)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4cc(N)ncc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-18-12-24(27-21(31)20(18)28-30)6-8-29(9-7-24)22(32)16-5-4-15-11-19(25)26-13-17(15)10-16/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152821
PNG
(US8993586, 100)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(N)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152822
PNG
(US8993586, 101)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4c(N)nccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-4-5-18-15(12-16)6-9-26-20(18)25/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152823
PNG
(US8993586, 103)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(Cl)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H26ClN5O2/c1-23(2,3)30-14-17-13-24(27-21(31)19(17)28-30)7-10-29(11-8-24)22(32)16-5-4-15-6-9-26-20(25)18(15)12-16/h4-6,9,12,14H,7-8,10-11,13H2,1-3H3,(H,27,31)
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152920
PNG
(US8993586, 117)
Show SMILES CCN(C)c1nccc2ccc(cc12)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C
Show InChI InChI=1S/C27H34N6O2/c1-6-31(5)23-21-15-19(8-7-18(21)9-12-28-23)25(35)32-13-10-27(11-14-32)16-20-17-33(26(2,3)4)30-22(20)24(34)29-27/h7-9,12,15,17H,6,10-11,13-14,16H2,1-5H3,(H,29,34)
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n/an/a 54n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152921
PNG
(US8993586, 118)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(NC5CCC5)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C28H34N6O2/c1-27(2,3)34-17-20-16-28(31-25(35)23(20)32-34)10-13-33(14-11-28)26(36)19-8-7-18-9-12-29-24(22(18)15-19)30-21-5-4-6-21/h7-9,12,15,17,21H,4-6,10-11,13-14,16H2,1-3H3,(H,29,30)(H,31,35)
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n/an/a 2.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM152925
PNG
(US8993586, 122)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4ccnc(NC5COC5)c4c3)NC(=O)c2n1
Show InChI InChI=1S/C27H32N6O3/c1-26(2,3)33-14-19-13-27(30-24(34)22(19)31-33)7-10-32(11-8-27)25(35)18-5-4-17-6-9-28-23(21(17)12-18)29-20-15-36-16-20/h4-6,9,12,14,20H,7-8,10-11,13,15-16H2,1-3H3,(H,28,29)(H,30,34)
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n/an/a 77n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM152878
PNG
(US8993586, 58)
Show SMILES CC(C)(C)n1cc2CC3(CCN(CC3)C(=O)c3ccc4nc(N)ccc4c3)NC(=O)c2n1
Show InChI InChI=1S/C24H28N6O2/c1-23(2,3)30-14-17-13-24(27-21(31)20(17)28-30)8-10-29(11-9-24)22(32)16-4-6-18-15(12-16)5-7-19(25)26-18/h4-7,12,14H,8-11,13H2,1-3H3,(H2,25,26)(H,27,31)
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n/an/a 149n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...


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More data for this
Ligand-Target Pair