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38 similar compounds to monomer 50249928

Compile data set for download or QSAR
Wt: 585.6
BDBM15359
Wt: 616.7
BDBM31996
Wt: 591.6
BDBM50030841
Wt: 583.6
BDBM50030907
Wt: 607.6
BDBM50173898
Wt: 673.7
BDBM50173899
Wt: 632.7
BDBM50173901
Wt: 630.7
BDBM50173903
Wt: 687.8
BDBM50173904
Wt: 645.7
BDBM50173909
Wt: 646.7
BDBM50173911
Wt: 660.7
BDBM50173913
Wt: 628.7
BDBM50249913
Wt: 642.7
BDBM50249914
Wt: 630.7
BDBM50249912
Displayed 1 to 15 (of 38 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 15359,31996,50030841,50030907,50173898,50173899,50173901,50173903,50173904,50173909,50173911,50173913,50249913,50249914,50249912   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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PubMed
4.60n/an/an/an/an/an/an/an/a



Biogen Idec Inc

Curated by ChEMBL


Assay Description
Inhibition of HSP90alpha


J Med Chem 53: 3-17 (2010)


Article DOI: 10.1021/jm9004708
BindingDB Entry DOI: 10.7270/Q2GM889J
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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9n/an/an/an/an/an/an/an/a



Biogen Idec Inc

Curated by ChEMBL


Assay Description
Binding affinity to HSP90 under reducing conditions in presence of TECP


J Med Chem 53: 3-17 (2010)


Article DOI: 10.1021/jm9004708
BindingDB Entry DOI: 10.7270/Q2GM889J
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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530n/an/an/an/an/an/an/an/a



Biogen Idec Inc

Curated by ChEMBL


Assay Description
Binding affinity to HSP90 under non-reducing conditions in absence of TECP


J Med Chem 53: 3-17 (2010)


Article DOI: 10.1021/jm9004708
BindingDB Entry DOI: 10.7270/Q2GM889J
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 7n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 1.27E+3n/a 160n/an/a7.422



Vernalis (R&D) Ltd



Assay Description
The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...


J Med Chem 51: 196-218 (2008)


Article DOI: 10.1021/jm701018h
BindingDB Entry DOI: 10.7270/Q2JW8C5C
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Department of Molecular Oncogenesis

Curated by ChEMBL


Assay Description
Inhibition of DNA dependent protein kinase activity without hsp90 alpha protein


Bioorg Med Chem Lett 11: 909-13 (2001)


Article DOI: 10.1016/s0960-894x(01)00099-3
BindingDB Entry DOI: 10.7270/Q2NV9HJX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Department of Molecular Oncogenesis

Curated by ChEMBL


Assay Description
Competitive binding towards Heat shock protein HSP 90-alpha


Bioorg Med Chem Lett 11: 909-13 (2001)


Article DOI: 10.1016/s0960-894x(01)00099-3
BindingDB Entry DOI: 10.7270/Q2NV9HJX
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 45n/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of GM-BODIPY from Hsp90


Bioorg Med Chem Lett 16: 3529-32 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.092
BindingDB Entry DOI: 10.7270/Q2S1824R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 64.9n/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of cy3B-GM from Hsp90alpha


Bioorg Med Chem Lett 16: 4515-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.025
BindingDB Entry DOI: 10.7270/Q24J0DR6
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 120n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha in human H1299 cells assessed as HIF-1alpha degradation by luciferase reporter assay


Bioorg Med Chem Lett 20: 7503-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.010
BindingDB Entry DOI: 10.7270/Q2JS9QSX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 60n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysis


Bioorg Med Chem Lett 20: 7503-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.010
BindingDB Entry DOI: 10.7270/Q2JS9QSX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assay


Bioorg Med Chem Lett 20: 7503-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.010
BindingDB Entry DOI: 10.7270/Q2JS9QSX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 9.80E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assay


Bioorg Med Chem Lett 20: 7503-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.010
BindingDB Entry DOI: 10.7270/Q2JS9QSX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 220n/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human HSP90alpha assessed as 2D1H-15N chemical shift perturbation by NMR spectroscopy


Bioorg Med Chem Lett 21: 5778-83 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2011.08.001
BindingDB Entry DOI: 10.7270/Q2QJ7HQX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 220n/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated N-terminal human HSP90alpha using of streptavidin coated surface by SPR binding assay


Bioorg Med Chem Lett 21: 5778-83 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2011.08.001
BindingDB Entry DOI: 10.7270/Q2QJ7HQX
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 1.19E+3n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Displacement of FITC-labeled geldanamycin from human recombinant HSP90alpha after 24 hrs by fluorescence diplacement assay


Bioorg Med Chem 19: 6055-68 (2011)


Article DOI: 10.1016/j.bmc.2011.08.048
BindingDB Entry DOI: 10.7270/Q2J38SZQ
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 1.27E+3n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Binding affinity to HSP90


Bioorg Med Chem 19: 6055-68 (2011)


Article DOI: 10.1016/j.bmc.2011.08.048
BindingDB Entry DOI: 10.7270/Q2J38SZQ
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 7.30n/an/an/an/an/a



Sanofi-Aventis Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assay


J Med Chem 54: 7206-19 (2011)


Article DOI: 10.1021/jm200784m
BindingDB Entry DOI: 10.7270/Q2QR4XH4
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50030841
PNG
((8S,9S,12S,13R,14S,16R)-19-(2-fluoroethylamino)-13...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCF
Show InChI InChI=1/C30H42FN3O8/c1-16-12-20-25(33-11-10-31)22(35)15-21(27(20)37)34-29(38)17(2)8-7-9-23(40-5)28(42-30(32)39)19(4)14-18(3)26(36)24(13-16)41-6/h7-9,11,14-16,18,23-24,26,28,35-37H,10,12-13H2,1-6H3,(H2,32,39)(H,34,38)/b9-7-,17-8+,19-14+,33-11+/t16-,18+,23+,24+,26-,28+/s2
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n/an/an/a 800n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173898
PNG
(CHEMBL371539 | Geldanamycin derivative)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)NO)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCF
Show InChI InChI=1S/C30H42FN3O9/c1-16-12-20-25(32-11-10-31)22(35)15-21(27(20)37)33-29(38)17(2)8-7-9-23(41-5)28(43-30(39)34-40)19(4)14-18(3)26(36)24(13-16)42-6/h7-9,11,14-16,18,23-24,26,28,35-37,40H,10,12-13H2,1-6H3,(H,33,38)(H,34,39)/b9-7-,17-8+,19-14+,32-11+/t16-,18+,23+,24+,26-,28+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173909
PNG
(CHEMBL370149 | N-Methyl-hydrazinecarboxylic acid (...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N(C)N)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1S/C33H51N5O8/c1-19-15-23-28(35-13-14-37(5)6)25(39)18-24(30(23)41)36-32(42)20(2)11-10-12-26(44-8)31(46-33(43)38(7)34)22(4)17-21(3)29(40)27(16-19)45-9/h10-13,17-19,21,26-27,29,31,39-41H,14-16,34H2,1-9H3,(H,36,42)/b12-10-,20-11+,22-17+,35-13+/t19-,21+,26+,27+,29-,31+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173901
PNG
(CHEMBL370404 | Geldanamycin derivative)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)NO)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1S/C32H48N4O9/c1-18-14-22-27(33-12-13-36(5)6)24(37)17-23(29(22)39)34-31(40)19(2)10-9-11-25(43-7)30(45-32(41)35-42)21(4)16-20(3)28(38)26(15-18)44-8/h9-12,16-18,20,25-26,28,30,37-39,42H,13-15H2,1-8H3,(H,34,40)(H,35,41)/b11-9-,19-10+,21-16+,33-12+/t18-,20+,25+,26+,28-,30+/m1/s1
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n/an/an/a 1.80E+4n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173903
PNG
(CHEMBL197795 | Methyl-carbamic acid (4E,6Z)-(13S,1...)
Show SMILES CNC(=O)O[C@@H]1[C@@H](OC)C=CC=C(C)C(=O)Nc2cc(O)c(N=CCN(C)C)c(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C1/C)c2O
Show InChI InChI=1S/C33H50N4O8/c1-19-15-23-28(35-13-14-37(6)7)25(38)18-24(30(23)40)36-32(41)20(2)11-10-12-26(43-8)31(45-33(42)34-5)22(4)17-21(3)29(39)27(16-19)44-9/h10-13,17-19,21,26-27,29,31,38-40H,14-16H2,1-9H3,(H,34,42)(H,36,41)/b12-10-,20-11+,22-17+,35-13+/t19-,21+,26+,27+,29-,31+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173904
PNG
((2-Dimethylamino-ethyl)-carbamic acid (4E,6Z)-(13S...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)NCCN(C)C)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1S/C36H57N5O8/c1-22-18-26-31(37-14-16-40(5)6)28(42)21-27(33(26)44)39-35(45)23(2)12-11-13-29(47-9)34(49-36(46)38-15-17-41(7)8)25(4)20-24(3)32(43)30(19-22)48-10/h11-14,20-22,24,29-30,32,34,42-44H,15-19H2,1-10H3,(H,38,46)(H,39,45)/b13-11-,23-12+,25-20+,37-14+/t22-,24+,29+,30+,32-,34+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173899
PNG
(CHEMBL197570 | Carbamoylmethyl-carbamic acid (4E,6...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)NCC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1S/C34H51N5O9/c1-19-14-23-29(36-12-13-39(5)6)25(40)17-24(31(23)43)38-33(44)20(2)10-9-11-26(46-7)32(48-34(45)37-18-28(35)41)22(4)16-21(3)30(42)27(15-19)47-8/h9-12,16-17,19,21,26-27,30,32,40,42-43H,13-15,18H2,1-8H3,(H2,35,41)(H,37,45)(H,38,44)/b11-9-,20-10+,22-16+,36-12+/t19-,21+,26+,27+,30-,32+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173913
PNG
((2-Hydroxy-ethyl)-carbamic acid (4E,6Z)-(13S,14S,1...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)NCCO)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1S/C34H52N4O9/c1-20-16-24-29(35-12-14-38(5)6)26(40)19-25(31(24)42)37-33(43)21(2)10-9-11-27(45-7)32(47-34(44)36-13-15-39)23(4)18-22(3)30(41)28(17-20)46-8/h9-12,18-20,22,27-28,30,32,39-42H,13-17H2,1-8H3,(H,36,44)(H,37,43)/b11-9-,21-10+,23-18+,35-12+/t20-,22+,27+,28+,30-,32+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM50173911
PNG
(CHEMBL198417 | Geldanamycin derivative)
Show SMILES CONC(=O)O[C@@H]1[C@@H](OC)C=CC=C(C)C(=O)Nc2cc(O)c(N=CCN(C)C)c(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C1/C)c2O
Show InChI InChI=1S/C33H50N4O9/c1-19-15-23-28(34-13-14-37(5)6)25(38)18-24(30(23)40)35-32(41)20(2)11-10-12-26(43-7)31(46-33(42)36-45-9)22(4)17-21(3)29(39)27(16-19)44-8/h10-13,17-19,21,26-27,29,31,38-40H,14-16H2,1-9H3,(H,35,41)(H,36,42)/b12-10-,20-11+,22-17+,34-13+/t19-,21+,26+,27+,29-,31+/m1/s1
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n/an/an/a>1.00E+5n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity for human heat shock protein 90 in scintillation proximity assay


Bioorg Med Chem Lett 15: 5016-21 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.013
BindingDB Entry DOI: 10.7270/Q23T9J19
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 22n/an/an/an/a



Infinity Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Upregulation of Hsp70 in SKBR3 cells


J Med Chem 49: 4606-15 (2006)


Article DOI: 10.1021/jm0603116
BindingDB Entry DOI: 10.7270/Q2RX9CWC
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 35n/an/an/an/a



Infinity Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Degradation of Her2 in SKBR3 cells


J Med Chem 49: 4606-15 (2006)


Article DOI: 10.1021/jm0603116
BindingDB Entry DOI: 10.7270/Q2RX9CWC
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 19n/an/an/an/a



Infinity Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Degradation of Her2 in SKOV3 cells


J Med Chem 49: 4606-15 (2006)


Article DOI: 10.1021/jm0603116
BindingDB Entry DOI: 10.7270/Q2RX9CWC
More data for this
Ligand-Target Pair
Heat shock protein 90 beta


(Canis familiaris)
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 124n/an/an/an/a



Infinity Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of BODIPY-AG binding to dog Grp94


J Med Chem 49: 4606-15 (2006)


Article DOI: 10.1021/jm0603116
BindingDB Entry DOI: 10.7270/Q2RX9CWC
More data for this
Ligand-Target Pair
Heat shock protein 75 kDa, mitochondrial


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...


J Med Chem 56: 6803-18 (2013)


Article DOI: 10.1021/jm400619b
BindingDB Entry DOI: 10.7270/Q2PN972K
More data for this
Ligand-Target Pair
Heat shock protein 90 beta


(Canis familiaris)
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 31n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...


J Med Chem 56: 6803-18 (2013)


Article DOI: 10.1021/jm400619b
BindingDB Entry DOI: 10.7270/Q2PN972K
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/an/a 110n/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Binding affinity towards Heat shock protein HSP 90-alpha inhibitor


Bioorg Med Chem Lett 13: 3975-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.065
BindingDB Entry DOI: 10.7270/Q2W958KM
More data for this
Ligand-Target Pair
Heat shock protein 90 beta


(Canis familiaris)
BDBM31996
PNG
(17-(dimethylaminoethylamino)-17-demethoxygeldanamy...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN(C)C
Show InChI InChI=1/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-12,16-18,20,25-26,28,30,37-39H,13-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+,34-12+/t18-,20+,25+,26+,28-,30+/s2
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n/an/an/an/a 65n/an/an/an/a



Infinity Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of BODIPY-AG binding to dog Grp94


J Med Chem 49: 4606-15 (2006)


Article DOI: 10.1021/jm0603116
BindingDB Entry DOI: 10.7270/Q2RX9CWC
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 326n/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Binding affinity to recombinant Hsp90 alpha (unknown origin) by surface plasmon resonance


J Med Chem 56: 1583-95 (2013)


Article DOI: 10.1021/jm301398y
BindingDB Entry DOI: 10.7270/Q2K938W3
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Saccharomyces cerevisiae)
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 6.60E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of yeast Hsp90 ATPase activity


Bioorg Med Chem Lett 15: 3338-43 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.046
BindingDB Entry DOI: 10.7270/Q22808T2
More data for this
Ligand-Target Pair
Heat Shock Protein 90 (Hsp90)


(Saccharomyces cerevisiae)
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 8.70E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of yeast Hsp90 ATPase activity


Bioorg Med Chem Lett 15: 3338-43 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.046
BindingDB Entry DOI: 10.7270/Q22808T2
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 12n/an/an/an/an/an/a



Biogen Idec Inc

Curated by ChEMBL


Assay Description
Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cells


J Med Chem 53: 3-17 (2010)


Article DOI: 10.1021/jm9004708
BindingDB Entry DOI: 10.7270/Q2GM889J
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 7n/an/an/an/an/an/a



Biogen Idec Inc

Curated by ChEMBL


Assay Description
Inhibition of HSP90-mediated client protein HER2 degradation


J Med Chem 53: 3-17 (2010)


Article DOI: 10.1021/jm9004708
BindingDB Entry DOI: 10.7270/Q2GM889J
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 760n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant Hsp90alpha N-terminal domain by scintillation proximity assay


J Med Chem 52: 1518-21 (2009)


Article DOI: 10.1021/jm900012a
BindingDB Entry DOI: 10.7270/Q2QN67Q8
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 160n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant Hsp90alpha N-terminal domain by isothermal titration calorimetry


J Med Chem 52: 1518-21 (2009)


Article DOI: 10.1021/jm900012a
BindingDB Entry DOI: 10.7270/Q2QN67Q8
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/an/a 1.30E+3n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM50030841
PNG
((8S,9S,12S,13R,14S,16R)-19-(2-fluoroethylamino)-13...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCF
Show InChI InChI=1/C30H42FN3O8/c1-16-12-20-25(33-11-10-31)22(35)15-21(27(20)37)34-29(38)17(2)8-7-9-23(40-5)28(42-30(32)39)19(4)14-18(3)26(36)24(13-16)41-6/h7-9,11,14-16,18,23-24,26,28,35-37H,10,12-13H2,1-6H3,(H2,32,39)(H,34,38)/b9-7-,17-8+,19-14+,33-11+/t16-,18+,23+,24+,26-,28+/s2
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n/an/an/a 800n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM50249912
PNG
(11-O-Methyl-17-[2-(dimethylamino)ethyl]amino-17-de...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)cc(O)c2N=CCN(C)C
Show InChI InChI=1/C33H50N4O8/c1-19-15-23-28(35-13-14-37(5)6)25(38)18-24(29(23)39)36-32(40)20(2)11-10-12-26(42-7)31(45-33(34)41)22(4)17-21(3)30(44-9)27(16-19)43-8/h10-13,17-19,21,26-27,30-31,38-39H,14-16H2,1-9H3,(H2,34,41)(H,36,40)/b12-10-,20-11+,22-17+,35-13+/t19-,21+,26+,27+,30-,31+/s2
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n/an/an/a 800n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM50249913
PNG
((8S,9S,12S,13R,14S,16R)-19-(2-(azetidin-1-yl)ethyl...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CCN1CCC1
Show InChI InChI=1/C33H48N4O8/c1-19-15-23-28(35-11-14-37-12-8-13-37)25(38)18-24(30(23)40)36-32(41)20(2)9-7-10-26(43-5)31(45-33(34)42)22(4)17-21(3)29(39)27(16-19)44-6/h7,9-11,17-19,21,26-27,29,31,38-40H,8,12-16H2,1-6H3,(H2,34,42)(H,36,41)/b10-7-,20-9+,22-17+,35-11+/t19-,21+,26+,27+,29-,31+/s2
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n/an/an/a 400n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM50249914
PNG
((8S,9S,12S,13R,14S,16R)-19-(2-(azetidin-1-yl)ethyl...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)cc(O)c2N=CCN1CCC1
Show InChI InChI=1/C34H50N4O8/c1-20-16-24-29(36-12-15-38-13-9-14-38)26(39)19-25(30(24)40)37-33(41)21(2)10-8-11-27(43-5)32(46-34(35)42)23(4)18-22(3)31(45-7)28(17-20)44-6/h8,10-12,18-20,22,27-28,31-32,39-40H,9,13-17H2,1-7H3,(H2,35,42)(H,37,41)/b11-8-,21-10+,23-18+,36-12+/t20-,22+,27+,28+,31-,32+/s2
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n/an/an/a 1.00E+3n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM50030907
PNG
((8S,9S,12S,14S,16R)-19-(allylamino)-8,14-dimethoxy...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)C1=O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H41N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,29,35,37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,29+/s2
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n/an/an/a 3.30E+3n/an/an/an/an/a



Kosan Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant HSP90


J Med Chem 52: 3265-73 (2009)


Article DOI: 10.1021/jm900098v
BindingDB Entry DOI: 10.7270/Q2V40W5R
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 33n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Binding affinity to Hsp90 in human SKBR3 cells


Bioorg Med Chem 17: 2225-35 (2009)


Article DOI: 10.1016/j.bmc.2008.10.087
BindingDB Entry DOI: 10.7270/Q2T72JCS
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-beta


(Homo sapiens (Human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+,33-12+/t17-,19+,24+,25+,27-,29+/s2
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n/an/a 15n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradation


Bioorg Med Chem 17: 2225-35 (2009)


Article DOI: 10.1016/j.bmc.2008.10.087
BindingDB Entry DOI: 10.7270/Q2T72JCS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 56 total )  |  Next  |  Last  >>

Activity Spreadsheet -- ITC Data from BindingDB

Found 8 hits for monomerid = 15359,31996,50030841,50030907,50173898,50173899,50173901,50173903,50173904,50173909,50173911,50173913,50249913,50249914,50249912
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM15359
JPEG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
GoogleScholar
PDB
CHEBI
PC cid
PC sid
-7.74-3.25-4.616.03810



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM15359
JPEG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
GoogleScholar
PDB
CHEBI
PC cid
PC sid
-7.69-1.48-6.215.88815



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM15359
JPEG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
GoogleScholar
PDB
CHEBI
PC cid
PC sid
-7.67-1.17-6.505.73820



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM15359
JPEG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
GoogleScholar
PDB
CHEBI
PC cid
PC sid
-7.62-0.768-6.855.51830



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM31996
JPEG
(17-(dimethylaminoethylamino)-17-demethoxygeldanamy...)
GoogleScholar
PDB
PC cid
PC sid
PDB
-7.62-2.77-4.875.80815



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM31996
JPEG
(17-(dimethylaminoethylamino)-17-demethoxygeldanamy...)
GoogleScholar
PDB
PC cid
PC sid
PDB
-7.57-1.93-5.645.65820



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM31996
JPEG
(17-(dimethylaminoethylamino)-17-demethoxygeldanamy...)
GoogleScholar
PDB
PC cid
PC sid
PDB
-7.69-1.82-5.885.64825



University College London





J Mol Biol 392: 923-36 (2009)

Heat Shock Protein 90 (Hsp90)

(Saccharomyces cerevisiae (Baker s yeast))
BDBM31996
JPEG
(17-(dimethylaminoethylamino)-17-demethoxygeldanamy...)
GoogleScholar
PDB
PC cid
PC sid
PDB
-7.71-1.03-6.715.60830



University College London





J Mol Biol 392: 923-36 (2009)