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6 similar compounds to monomer 50290845

Compile data set for download or QSAR
Wt: 310.3
BDBM153651
Purchase
Wt: 310.3
BDBM153647
Wt: 429.5
BDBM50141827
Wt: 311.3
BDBM50290842
Wt: 309.3
BDBM50290843
Wt: 281.3
BDBM50290853

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 153651,153647,50141827,50290842,50290843,50290853   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM153647
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-3-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)cc3C)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-8-12(19)4-5-15(11)23-16-6-7-20-14-10-18(22-3)17(21-2)9-13(14)16/h4-10H,19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...


US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM153651
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-2-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)c(C)c3)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-8-12(4-5-14(11)19)23-16-6-7-20-15-10-18(22-3)17(21-2)9-13(15)16/h4-10H,19H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

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US Patent
n/an/a>1.00E+4n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...


US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290853
PNG
(6,7-Dimethoxy-4-phenoxy-quinoline | CHEMBL327534)
Show SMILES COc1cc2nccc(Oc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H15NO3/c1-19-16-10-13-14(11-17(16)20-2)18-9-8-15(13)21-12-6-4-3-5-7-12/h3-11H,1-2H3
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Article
n/an/a 760n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290842
PNG
(6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline | CH...)
Show SMILES COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H17NO4/c1-20-12-4-6-13(7-5-12)23-16-8-9-19-15-11-18(22-3)17(21-2)10-14(15)16/h4-11H,1-3H3
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Article
n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290843
PNG
(4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)
Show SMILES CCc1cccc(Oc2ccnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H19NO3/c1-4-13-6-5-7-14(10-13)23-17-8-9-20-16-12-19(22-3)18(21-2)11-15(16)17/h5-12H,4H2,1-3H3
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Article
n/an/a 8.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50141827
PNG
(4-[4-(4-tert-Butyl-phenoxy)-phenoxy]-6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc(Oc4ccc(cc4)C(C)(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C27H27NO4/c1-27(2,3)18-6-8-19(9-7-18)31-20-10-12-21(13-11-20)32-24-14-15-28-23-17-26(30-5)25(29-4)16-22(23)24/h6-17H,1-5H3
PDB
MMDB

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PubMed
n/an/a 440n/an/an/an/an/an/a



Kirin Brewery Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line


Bioorg Med Chem Lett 14: 875-9 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV
More data for this
Ligand-Target Pair