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4 similar compounds to monomer 50290843

Compile data set for download or QSAR
Wt: 310.3
BDBM153651
Purchase
Wt: 429.5
BDBM50141827
Wt: 427.5
BDBM50141830
Wt: 295.3
BDBM50290845

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 153651,50141827,50141830,50290845   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM153651
PNG
(US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)-2-...)
Show SMILES COc1cc2nccc(Oc3ccc(N)c(C)c3)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-8-12(4-5-14(11)19)23-16-6-7-20-15-10-18(22-3)17(21-2)9-13(15)16/h4-10H,19H2,1-3H3
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GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/a8.0n/a



Lead Discovery Center GmbH; Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

US Patent


Assay Description
The principle behind this assay is based upon the binding and displacement of an Alexa Fluor 647-labeled tracer to the kinase of interest. Binding of...


US Patent US8999982 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z4D
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290845
PNG
(6,7-Dimethoxy-4-m-tolyloxy-quinoline | CHEMBL98839)
Show SMILES COc1cc2nccc(Oc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C18H17NO3/c1-12-5-4-6-13(9-12)22-16-7-8-19-15-11-18(21-3)17(20-2)10-14(15)16/h4-11H,1-3H3
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Article
n/an/a 6.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50141830
PNG
(4-[4-(4-tert-Butyl-benzyl)-phenoxy]-6,7-dimethoxy-...)
Show SMILES COc1cc2nccc(Oc3ccc(Cc4ccc(cc4)C(C)(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C28H29NO3/c1-28(2,3)21-10-6-19(7-11-21)16-20-8-12-22(13-9-20)32-25-14-15-29-24-18-27(31-5)26(30-4)17-23(24)25/h6-15,17-18H,16H2,1-5H3
PDB
MMDB

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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Kirin Brewery Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line


Bioorg Med Chem Lett 14: 875-9 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50141827
PNG
(4-[4-(4-tert-Butyl-phenoxy)-phenoxy]-6,7-dimethoxy...)
Show SMILES COc1cc2nccc(Oc3ccc(Oc4ccc(cc4)C(C)(C)C)cc3)c2cc1OC
Show InChI InChI=1S/C27H27NO4/c1-27(2,3)18-6-8-19(9-7-18)31-20-10-12-21(13-11-20)32-24-14-15-28-23-17-26(30-5)25(29-4)16-22(23)24/h6-17H,1-5H3
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Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Kirin Brewery Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line


Bioorg Med Chem Lett 14: 875-9 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.019
BindingDB Entry DOI: 10.7270/Q2TB16BV
More data for this
Ligand-Target Pair