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44 similar compounds to monomer 168079

Compile data set for download or QSAR
Wt: 439.4
BDBM155256
Wt: 469.4
BDBM155257
Wt: 469.4
BDBM155258
Wt: 481.4
BDBM168072
Wt: 497.5
BDBM168073
Wt: 511.5
BDBM168074
Wt: 469.4
BDBM168075
Wt: 482.4
BDBM168076
Wt: 511.5
BDBM168077
Wt: 511.5
BDBM168078
Wt: 525.5
BDBM168085
Wt: 525.5
BDBM168086
Wt: 541.5
BDBM168093
Wt: 499.5
BDBM168094
Wt: 499.5
BDBM168095
Displayed 1 to 15 (of 44 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 155256,155257,155258,168072,168073,168074,168075,168076,168077,168078,168085,168086,168093,168094,168095   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168093
PNG
(US9073931, E12)
Show SMILES CCOC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O5S/c1-5-36-21(33)14-10-27-22(29-19(14)23(24,25)26)31-7-6-30-16-9-17(37(4,34)35)13(11-32)8-15(16)28-20(30)18(31)12(2)3/h8-10,12,18,32H,5-7,11H2,1-4H3/t18-/m1/s1
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6 -11.2n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168077
PNG
(US9073931, E6a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O4S/c1-11(2)18-20-27-15-7-13(10-31)17(35(4,33)34)8-16(15)29(20)5-6-30(18)21-26-9-14(12(3)32)19(28-21)22(23,24)25/h7-9,11,18,31H,5-6,10H2,1-4H3/t18-/m1/s1
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14 -10.7n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168085
PNG
(US9073931, E9a)
Show SMILES CCC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O4S/c1-5-17(33)14-10-27-22(29-20(14)23(24,25)26)31-7-6-30-16-9-18(36(4,34)35)13(11-32)8-15(16)28-21(30)19(31)12(2)3/h8-10,12,19,32H,5-7,11H2,1-4H3/t19-/m1/s1
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17 -10.6n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168094
PNG
(US9073931, E13a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m1/s1
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17 -10.6n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155257
PNG
(US9006244, E2a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m1/s1
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20n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168093
PNG
(US9073931, E12)
Show SMILES CCOC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O5S/c1-5-36-21(33)14-10-27-22(29-19(14)23(24,25)26)31-7-6-30-16-9-17(37(4,34)35)13(11-32)8-15(16)28-20(30)18(31)12(2)3/h8-10,12,18,32H,5-7,11H2,1-4H3/t18-/m1/s1
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49 -9.97n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168085
PNG
(US9073931, E9a)
Show SMILES CCC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O4S/c1-5-17(33)14-10-27-22(29-20(14)23(24,25)26)31-7-6-30-16-9-18(36(4,34)35)13(11-32)8-15(16)28-21(30)19(31)12(2)3/h8-10,12,19,32H,5-7,11H2,1-4H3/t19-/m1/s1
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136 -9.36n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168075
PNG
(US9073931, E4)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)16-18-25-14-5-4-13(32(3,30)31)8-15(14)27(18)6-7-28(16)19-24-9-12(10-29)17(26-19)20(21,22)23/h4-5,8-9,11,16,29H,6-7,10H2,1-3H3
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137 -9.36n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168073
PNG
(US9073931, E2)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(c(n1)C(F)(F)F)C(C)(C)O
Show InChI InChI=1S/C22H26F3N5O3S/c1-12(2)17-19-27-15-7-6-13(34(5,32)33)10-16(15)29(19)8-9-30(17)20-26-11-14(21(3,4)31)18(28-20)22(23,24)25/h6-7,10-12,17,31H,8-9H2,1-5H3
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176 -9.21n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168072
PNG
(US9073931, E1)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3S/c1-11(2)17-19-26-15-6-5-13(33(4,31)32)9-16(15)28(19)7-8-29(17)20-25-10-14(12(3)30)18(27-20)21(22,23)24/h5-6,9-11,17H,7-8H2,1-4H3
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191 -9.16n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155256
PNG
(US9006244, E1)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O2S/c1-11(2)16-17-24-13-5-4-12(30(3,28)29)10-14(13)26(17)8-9-27(16)18-23-7-6-15(25-18)19(20,21)22/h4-7,10-11,16H,8-9H2,1-3H3
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256n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168077
PNG
(US9073931, E6a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O4S/c1-11(2)18-20-27-15-7-13(10-31)17(35(4,33)34)8-16(15)29(20)5-6-30(18)21-26-9-14(12(3)32)19(28-21)22(23,24)25/h7-9,11,18,31H,5-6,10H2,1-4H3/t18-/m1/s1
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277 -8.94n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155257
PNG
(US9006244, E2a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m1/s1
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318n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168094
PNG
(US9073931, E13a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m1/s1
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409 -8.71n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168095
PNG
(US9073931, E13b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m0/s1
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1.04E+3 -8.16n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168074
PNG
(US9073931, E3)
Show SMILES CCOC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3ccc(cc23)S(C)(=O)=O)C1C(C)C
Show InChI InChI=1S/C22H24F3N5O4S/c1-5-34-20(31)14-11-26-21(28-18(14)22(23,24)25)30-9-8-29-16-10-13(35(4,32)33)6-7-15(16)27-19(29)17(30)12(2)3/h6-7,10-12,17H,5,8-9H2,1-4H3
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1.16E+3 -8.09n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168078
PNG
(US9073931, E6b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O4S/c1-11(2)18-20-27-15-7-13(10-31)17(35(4,33)34)8-16(15)29(20)5-6-30(18)21-26-9-14(12(3)32)19(28-21)22(23,24)25/h7-9,11,18,31H,5-6,10H2,1-4H3/t18-/m0/s1
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1.19E+3 -8.08n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168086
PNG
(US9073931, E9b)
Show SMILES CCC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O4S/c1-5-17(33)14-10-27-22(29-20(14)23(24,25)26)31-7-6-30-16-9-18(36(4,34)35)13(11-32)8-15(16)28-21(30)19(31)12(2)3/h8-10,12,19,32H,5-7,11H2,1-4H3/t19-/m0/s1
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1.36E+3 -8.00n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168072
PNG
(US9073931, E1)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H22F3N5O3S/c1-11(2)17-19-26-15-6-5-13(33(4,31)32)9-16(15)28(19)7-8-29(17)20-25-10-14(12(3)30)18(27-20)21(22,23)24/h5-6,9-11,17H,7-8H2,1-4H3
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US Patent
1.40E+3 -7.98n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168075
PNG
(US9073931, E4)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)16-18-25-14-5-4-13(32(3,30)31)8-15(14)27(18)6-7-28(16)19-24-9-12(10-29)17(26-19)20(21,22)23/h4-5,8-9,11,16,29H,6-7,10H2,1-3H3
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US Patent
1.54E+3 -7.92n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168073
PNG
(US9073931, E2)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(c(n1)C(F)(F)F)C(C)(C)O
Show InChI InChI=1S/C22H26F3N5O3S/c1-12(2)17-19-27-15-7-6-13(34(5,32)33)10-16(15)29(19)8-9-30(17)20-26-11-14(21(3,4)31)18(28-20)22(23,24)25/h6-7,10-12,17,31H,8-9H2,1-5H3
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US Patent
1.60E+3 -7.90n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155256
PNG
(US9006244, E1)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C19H20F3N5O2S/c1-11(2)16-17-24-13-5-4-12(30(3,28)29)10-14(13)26(17)8-9-27(16)18-23-7-6-15(25-18)19(20,21)22/h4-7,10-11,16H,8-9H2,1-3H3
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US Patent
1.77E+3n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168076
PNG
(US9073931, E5)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(C(N)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3S/c1-10(2)15-18-26-13-5-4-11(33(3,31)32)8-14(13)28(18)6-7-29(15)19-25-9-12(17(24)30)16(27-19)20(21,22)23/h4-5,8-10,15H,6-7H2,1-3H3,(H2,24,30)
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>2.50E+3>-7.64n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155258
PNG
(US9006244, E2b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m0/s1
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>2.50E+3n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168095
PNG
(US9073931, E13b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m0/s1
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155258
PNG
(US9006244, E2b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m0/s1
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>3.33E+3n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168086
PNG
(US9073931, E9b)
Show SMILES CCC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3cc(CO)c(cc23)S(C)(=O)=O)[C@@H]1C(C)C
Show InChI InChI=1S/C23H26F3N5O4S/c1-5-17(33)14-10-27-22(29-20(14)23(24,25)26)31-7-6-30-16-9-18(36(4,34)35)13(11-32)8-15(16)28-21(30)19(31)12(2)3/h8-10,12,19,32H,5-7,11H2,1-4H3/t19-/m0/s1
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168076
PNG
(US9073931, E5)
Show SMILES CC(C)C1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(C(N)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3S/c1-10(2)15-18-26-13-5-4-11(33(3,31)32)8-14(13)28(18)6-7-29(15)19-25-9-12(17(24)30)16(27-19)20(21,22)23/h4-5,8-10,15H,6-7H2,1-3H3,(H2,24,30)
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168078
PNG
(US9073931, E6b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C(C)=O)c(n1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O4S/c1-11(2)18-20-27-15-7-13(10-31)17(35(4,33)34)8-16(15)29(20)5-6-30(18)21-26-9-14(12(3)32)19(28-21)22(23,24)25/h7-9,11,18,31H,5-6,10H2,1-4H3/t18-/m0/s1
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168074
PNG
(US9073931, E3)
Show SMILES CCOC(=O)c1cnc(nc1C(F)(F)F)N1CCn2c(nc3ccc(cc23)S(C)(=O)=O)C1C(C)C
Show InChI InChI=1S/C22H24F3N5O4S/c1-5-34-20(31)14-11-26-21(28-18(14)22(23,24)25)30-9-8-29-16-10-13(35(4,32)33)6-7-15(16)27-19(29)17(30)12(2)3/h6-7,10-12,17H,5,8-9H2,1-4H3
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair