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37 similar compounds to monomer 156743

Compile data set for download or QSAR
Wt: 378.3
BDBM157089
Wt: 360.4
BDBM156686
Wt: 382.3
BDBM157096
Wt: 382.3
BDBM157097
Wt: 382.3
BDBM157098
Wt: 398.8
BDBM157108
Wt: 398.8
BDBM157111
Wt: 432.3
BDBM157123
Wt: 428.4
BDBM156717
Wt: 412.8
BDBM156718
Wt: 378.3
BDBM156719
Wt: 394.8
BDBM156720
Wt: 374.4
BDBM156721
Wt: 428.4
BDBM156722
Wt: 428.4
BDBM156723
Displayed 1 to 15 (of 37 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 157089,156686,157096,157097,157098,157108,157111,157123,156717,156718,156719,156720,156721,156722,156723   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156686
PNG
(US9029559, 37)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c1-15-8-5-6-11-17(15)20(14-21(25)26)24-22(27)19-13-7-12-18(23-19)16-9-3-2-4-10-16/h2-13,20H,14H2,1H3,(H,24,27)(H,25,26)/t20-/m0/s1
PDB

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UniChem

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US Patent
n/an/a 130n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157123
PNG
(US9029559, 607)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H16F4N2O3/c23-16-9-4-2-7-14(16)17-10-5-11-18(27-17)21(31)28-19(12-20(29)30)13-6-1-3-8-15(13)22(24,25)26/h1-11,19H,12H2,(H,28,31)(H,29,30)/t19-/m0/s1
PDB

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US Patent
n/an/a 880n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156718
PNG
(US9029559, 134)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H18ClFN2O3/c1-13-5-2-3-6-15(13)20(12-21(27)28)26-22(29)19-8-4-7-18(25-19)14-9-10-17(24)16(23)11-14/h2-11,20H,12H2,1H3,(H,26,29)(H,27,28)/t20-/m0/s1
PDB

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US Patent
n/an/a 3.62E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156719
PNG
(US9029559, 135)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN2O3/c1-14-5-2-3-6-17(14)20(13-21(26)27)25-22(28)19-8-4-7-18(24-19)15-9-11-16(23)12-10-15/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.18E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156720
PNG
(US9029559, 136)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H19ClN2O3/c1-14-5-2-3-6-17(14)20(13-21(26)27)25-22(28)19-8-4-7-18(24-19)15-9-11-16(23)12-10-15/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 4.85E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156721
PNG
(US9029559, 137)
Show SMILES Cc1ccc(cc1)-c1cccc(n1)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C23H22N2O3/c1-15-10-12-17(13-11-15)19-8-5-9-20(24-19)23(28)25-21(14-22(26)27)18-7-4-3-6-16(18)2/h3-13,21H,14H2,1-2H3,(H,25,28)(H,26,27)/t21-/m0/s1
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US Patent
n/an/a 1.24E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156722
PNG
(US9029559, 138)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O3/c1-14-5-2-3-6-17(14)20(13-21(29)30)28-22(31)19-8-4-7-18(27-19)15-9-11-16(12-10-15)23(24,25)26/h2-12,20H,13H2,1H3,(H,28,31)(H,29,30)/t20-/m0/s1
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US Patent
n/an/a 6.83E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156723
PNG
(US9029559, 139)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O3/c1-14-7-2-3-8-15(14)20(13-21(29)30)28-22(31)19-12-6-11-18(27-19)16-9-4-5-10-17(16)23(24,25)26/h2-12,20H,13H2,1H3,(H,28,31)(H,29,30)/t20-/m0/s1
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US Patent
n/an/a 1.09E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157089
PNG
(US9029559, 560)
Show SMILES Cc1cccc(c1)[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1F
Show InChI InChI=1S/C22H19FN2O3/c1-14-6-4-7-15(12-14)20(13-21(26)27)25-22(28)19-11-5-10-18(24-19)16-8-2-3-9-17(16)23/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.29E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157096
PNG
(US9029559, 569)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1cccc(F)c1
Show InChI InChI=1S/C21H16F2N2O3/c22-14-6-3-5-13(11-14)19(12-20(26)27)25-21(28)18-10-4-9-17(24-18)15-7-1-2-8-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 429n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157097
PNG
(US9029559, 570)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C21H16F2N2O3/c22-15-8-3-1-6-13(15)17-10-5-11-18(24-17)21(28)25-19(12-20(26)27)14-7-2-4-9-16(14)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 195n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157098
PNG
(US9029559, 571)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccc(F)cc1
Show InChI InChI=1S/C21H16F2N2O3/c22-14-10-8-13(9-11-14)19(12-20(26)27)25-21(28)18-7-3-6-17(24-18)15-4-1-2-5-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 514n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157108
PNG
(US9029559, 588)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H16ClFN2O3/c22-16-5-2-1-4-15(16)17-6-3-7-18(24-17)21(28)25-19(12-20(26)27)13-8-10-14(23)11-9-13/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 107n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157111
PNG
(US9029559, 591)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClFN2O3/c22-14-10-8-13(9-11-14)19(12-20(26)27)25-21(28)18-7-3-6-17(24-18)15-4-1-2-5-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 322n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156717
PNG
(US9029559, 133)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O3/c1-14-6-2-3-9-17(14)20(13-21(29)30)28-22(31)19-11-5-10-18(27-19)15-7-4-8-16(12-15)23(24,25)26/h2-12,20H,13H2,1H3,(H,28,31)(H,29,30)/t20-/m0/s1
PDB

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US Patent
n/an/a 5.76E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair