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34 similar compounds to monomer 157119

Compile data set for download or QSAR
Wt: 378.3
BDBM157089
Wt: 380.8
BDBM157092
Wt: 380.8
BDBM157095
Wt: 360.4
BDBM156686
Wt: 382.3
BDBM157098
Wt: 394.8
BDBM157100
Wt: 394.8
BDBM157101
Wt: 394.8
BDBM157102
Wt: 398.8
BDBM157106
Wt: 398.8
BDBM157107
Wt: 398.8
BDBM157108
Wt: 398.8
BDBM157109
Wt: 398.8
BDBM157110
Wt: 398.8
BDBM157111
Wt: 410.8
BDBM157112
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 157089,157092,157095,156686,157098,157100,157101,157102,157106,157107,157108,157109,157110,157111,157112   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156686
PNG
(US9029559, 37)
Show SMILES Cc1ccccc1[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c1-15-8-5-6-11-17(15)20(14-21(25)26)24-22(27)19-13-7-12-18(23-19)16-9-3-2-4-10-16/h2-13,20H,14H2,1H3,(H,24,27)(H,25,26)/t20-/m0/s1
PDB

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UniProtKB/SwissProt

B.MOAD
GoogleScholar
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UniChem

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US Patent
n/an/a 130n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157112
PNG
(US9029559, 595)
Show SMILES COc1ccc(cc1)-c1cccc(n1)C(=O)NC(CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN2O4/c1-29-15-11-9-14(10-12-15)18-7-4-8-19(24-18)22(28)25-20(13-21(26)27)16-5-2-3-6-17(16)23/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)
PDB

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US Patent
n/an/a 1.42E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157092
PNG
(US9029559, 563)
Show SMILES OC(=O)CC(NC(=O)c1cccc(n1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O3/c22-16-10-5-4-9-15(16)19(13-20(25)26)24-21(27)18-12-6-11-17(23-18)14-7-2-1-3-8-14/h1-12,19H,13H2,(H,24,27)(H,25,26)
PDB

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US Patent
n/an/a 3.09E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157095
PNG
(US9029559, 567)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C21H17ClN2O3/c22-16-10-5-4-9-15(16)17-11-6-12-18(23-17)21(27)24-19(13-20(25)26)14-7-2-1-3-8-14/h1-12,19H,13H2,(H,24,27)(H,25,26)/t19-/m0/s1
PDB

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US Patent
n/an/a 2.18E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157098
PNG
(US9029559, 571)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccc(F)cc1
Show InChI InChI=1S/C21H16F2N2O3/c22-14-10-8-13(9-11-14)19(12-20(26)27)25-21(28)18-7-3-6-17(24-18)15-4-1-2-5-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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PC cid
PC sid
UniChem

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US Patent
n/an/a 514n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157100
PNG
(US9029559, 580)
Show SMILES Cc1ccc(cc1)[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN2O3/c1-14-9-11-15(12-10-14)20(13-21(26)27)25-22(28)19-8-4-7-18(24-19)16-5-2-3-6-17(16)23/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.56E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157101
PNG
(US9029559, 581)
Show SMILES C[C@@](CC(O)=O)(NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccccc1
Show InChI InChI=1S/C22H19ClN2O3/c1-22(14-20(26)27,15-8-3-2-4-9-15)25-21(28)19-13-7-12-18(24-19)16-10-5-6-11-17(16)23/h2-13H,14H2,1H3,(H,25,28)(H,26,27)/t22-/m0/s1
PDB

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US Patent
n/an/a 5.76E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157102
PNG
(US9029559, 582)
Show SMILES Cc1cccc(c1)[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN2O3/c1-14-6-4-7-15(12-14)20(13-21(26)27)25-22(28)19-11-5-10-18(24-19)16-8-2-3-9-17(16)23/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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UniProtKB/SwissProt

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UniChem

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US Patent
n/an/a 160n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157106
PNG
(US9029559, 586)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccccc1F
Show InChI InChI=1S/C21H16ClFN2O3/c22-15-8-3-1-6-13(15)17-10-5-11-18(24-17)21(28)25-19(12-20(26)27)14-7-2-4-9-16(14)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 339n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157107
PNG
(US9029559, 587)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1cccc(F)c1
Show InChI InChI=1S/C21H16ClFN2O3/c22-16-8-2-1-7-15(16)17-9-4-10-18(24-17)21(28)25-19(12-20(26)27)13-5-3-6-14(23)11-13/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 7.35E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157108
PNG
(US9029559, 588)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H16ClFN2O3/c22-16-5-2-1-4-15(16)17-6-3-7-18(24-17)21(28)25-19(12-20(26)27)13-8-10-14(23)11-9-13/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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US Patent
n/an/a 107n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157109
PNG
(US9029559, 589)
Show SMILES OC(=O)CC(NC(=O)c1cccc(n1)-c1ccccc1F)c1ccccc1Cl
Show InChI InChI=1S/C21H16ClFN2O3/c22-15-8-3-1-6-13(15)19(12-20(26)27)25-21(28)18-11-5-10-17(24-18)14-7-2-4-9-16(14)23/h1-11,19H,12H2,(H,25,28)(H,26,27)
PDB

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US Patent
n/an/a 4.89E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157110
PNG
(US9029559, 590)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1cccc(Cl)c1
Show InChI InChI=1S/C21H16ClFN2O3/c22-14-6-3-5-13(11-14)19(12-20(26)27)25-21(28)18-10-4-9-17(24-18)15-7-1-2-8-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 339n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157111
PNG
(US9029559, 591)
Show SMILES OC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccccc1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClFN2O3/c22-14-10-8-13(9-11-14)19(12-20(26)27)25-21(28)18-7-3-6-17(24-18)15-4-1-2-5-16(15)23/h1-11,19H,12H2,(H,25,28)(H,26,27)/t19-/m0/s1
PDB

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US Patent
n/an/a 322n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM157089
PNG
(US9029559, 560)
Show SMILES Cc1cccc(c1)[C@H](CC(O)=O)NC(=O)c1cccc(n1)-c1ccccc1F
Show InChI InChI=1S/C22H19FN2O3/c1-14-6-4-7-15(12-14)20(13-21(26)27)25-22(28)19-11-5-10-18(24-19)16-8-2-3-9-17(16)23/h2-12,20H,13H2,1H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.29E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair