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17 similar compounds to monomer 160439

Compile data set for download or QSAR
Wt: 407.4
BDBM160438
Wt: 432.4
BDBM160440
Wt: 377.3
BDBM160441
Wt: 420.4
BDBM160443
Wt: 363.3
BDBM160449
Wt: 375.3
BDBM160450
Wt: 419.4
BDBM160458
Wt: 432.4
BDBM160459
Wt: 407.4
BDBM160460
Wt: 420.4
BDBM160461
Wt: 462.4
BDBM160462
Wt: 375.3
BDBM160463
Wt: 388.4
BDBM160464
Wt: 363.3
BDBM160465
Wt: 418.4
BDBM160466
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 160438,160440,160441,160443,160449,160450,160458,160459,160460,160461,160462,160463,160464,160465,160466   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160438
PNG
(US9040714, 152 | US9693992, 152)
Show SMILES COCCNC(=O)CCc1c(C)c2c(OCCOC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C20H25NO8/c1-12-13(4-5-17(24)21-6-7-26-2)20(25)29-19-14(11-22)15(23)10-16(18(12)19)28-9-8-27-3/h10-11,23H,4-9H2,1-3H3,(H,21,24)
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n/an/a<1.00E+3n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160466
PNG
(US9040714, 196 | US9693992, 196)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)NCCN3CCOCC3)c(C)c12
Show InChI InChI=1S/C21H26N2O7/c1-13-14(3-4-18(26)22-5-6-23-7-9-29-10-8-23)21(27)30-20-15(12-24)16(25)11-17(28-2)19(13)20/h11-12,25H,3-10H2,1-2H3,(H,22,26)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160441
PNG
(US9040714, 155 | US9693992, 155)
Show SMILES CCNC(=O)CCc1c(C)c2c(OCCOC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C19H23NO7/c1-4-20-16(23)6-5-12-11(2)17-15(26-8-7-25-3)9-14(22)13(10-21)18(17)27-19(12)24/h9-10,22H,4-8H2,1-3H3,(H,20,23)
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n/an/a<1.00E+3n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160443
PNG
(US9040714, 157 | US9693992, 157)
Show SMILES COCCOc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)NCCN(C)C)c(C)c12
Show InChI InChI=1S/C21H28N2O7/c1-13-14(5-6-18(26)22-7-8-23(2)3)21(27)30-20-15(12-24)16(25)11-17(19(13)20)29-10-9-28-4/h11-12,25H,5-10H2,1-4H3,(H,22,26)
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n/an/a<1.00E+3n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160449
PNG
(US9040714, 171 | US9693992, 171)
Show SMILES COCCNC(=O)CCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(21)19-6-7-24-2)18(23)26-17-12(10)8-14(25-3)16(22)13(17)9-20/h8-9,22H,4-7H2,1-3H3,(H,19,21)
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160450
PNG
(US9040714, 172 | US9693992, 172)
Show SMILES COc1cc2c(C)c(CCC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C19H21NO7/c1-11-12(3-4-16(22)20-5-7-26-8-6-20)19(24)27-18-13(11)9-15(25-2)17(23)14(18)10-21/h9-10,23H,3-8H2,1-2H3
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160458
PNG
(US9040714, 181 | US9693992, 181)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C21H25NO8/c1-13-14(3-4-18(24)22-5-7-28-8-6-22)21(26)30-20-15(13)11-17(29-10-9-27-2)19(25)16(20)12-23/h11-12,25H,3-10H2,1-2H3
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160459
PNG
(US9040714, 182 | US9693992, 182)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)N3CCN(C)CC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C22H28N2O7/c1-14-15(4-5-19(26)24-8-6-23(2)7-9-24)22(28)31-21-16(14)12-18(30-11-10-29-3)20(27)17(21)13-25/h12-13,27H,4-11H2,1-3H3
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160460
PNG
(US9040714, 184 | US9693992, 184)
Show SMILES COCCNC(=O)CCc1c(C)c2cc(OCCOC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C20H25NO8/c1-12-13(4-5-17(23)21-6-7-26-2)20(25)29-19-14(12)10-16(28-9-8-27-3)18(24)15(19)11-22/h10-11,24H,4-9H2,1-3H3,(H,21,23)
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160461
PNG
(US9040714, 185 | US9693992, 185)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)NCCN(C)C)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C21H28N2O7/c1-13-14(5-6-18(25)22-7-8-23(2)3)21(27)30-20-15(13)11-17(29-10-9-28-4)19(26)16(20)12-24/h11-12,26H,5-10H2,1-4H3,(H,22,25)
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160462
PNG
(US9040714, 186 | US9693992, 186)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)NCCN3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C23H30N2O8/c1-15-16(3-4-20(27)24-5-6-25-7-9-31-10-8-25)23(29)33-22-17(15)13-19(32-12-11-30-2)21(28)18(22)14-26/h13-14,28H,3-12H2,1-2H3,(H,24,27)
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n/an/a<1.00E+3n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160463
PNG
(US9040714, 192 | US9693992, 192)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCOCC3)c(C)c12
Show InChI InChI=1S/C19H21NO7/c1-11-12(3-4-16(23)20-5-7-26-8-6-20)19(24)27-18-13(10-21)14(22)9-15(25-2)17(11)18/h9-10,22H,3-8H2,1-2H3
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n/an/a<1.00E+3n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160464
PNG
(US9040714, 193 | US9693992, 193)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C20H24N2O6/c1-12-13(4-5-17(25)22-8-6-21(2)7-9-22)20(26)28-19-14(11-23)15(24)10-16(27-3)18(12)19/h10-11,24H,4-9H2,1-3H3
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160465
PNG
(US9040714, 194 | US9693992, 194)
Show SMILES COCCNC(=O)CCc1c(C)c2c(OC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(22)19-6-7-24-2)18(23)26-17-12(9-20)13(21)8-14(25-3)16(10)17/h8-9,21H,4-7H2,1-3H3,(H,19,22)
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160466
PNG
(US9040714, 196 | US9693992, 196)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)NCCN3CCOCC3)c(C)c12
Show InChI InChI=1S/C21H26N2O7/c1-13-14(3-4-18(26)22-5-6-23-7-9-29-10-8-23)21(27)30-20-15(12-24)16(25)11-17(28-2)19(13)20/h11-12,25H,3-10H2,1-2H3,(H,22,26)
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160438
PNG
(US9040714, 152 | US9693992, 152)
Show SMILES COCCNC(=O)CCc1c(C)c2c(OCCOC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C20H25NO8/c1-12-13(4-5-17(24)21-6-7-26-2)20(25)29-19-14(11-22)15(23)10-16(18(12)19)28-9-8-27-3/h10-11,23H,4-9H2,1-3H3,(H,21,24)
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n/an/a<1.00E+3n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160440
PNG
(US9040714, 154 | US9693992, 154)
Show SMILES COCCOc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C22H28N2O7/c1-14-15(4-5-19(27)24-8-6-23(2)7-9-24)22(28)31-21-16(13-25)17(26)12-18(20(14)21)30-11-10-29-3/h12-13,26H,4-11H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160441
PNG
(US9040714, 155 | US9693992, 155)
Show SMILES CCNC(=O)CCc1c(C)c2c(OCCOC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C19H23NO7/c1-4-20-16(23)6-5-12-11(2)17-15(26-8-7-25-3)9-14(22)13(10-21)18(17)27-19(12)24/h9-10,22H,4-8H2,1-3H3,(H,20,23)
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n/an/a<1.00E+3n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160443
PNG
(US9040714, 157 | US9693992, 157)
Show SMILES COCCOc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)NCCN(C)C)c(C)c12
Show InChI InChI=1S/C21H28N2O7/c1-13-14(5-6-18(26)22-7-8-23(2)3)21(27)30-20-15(12-24)16(25)11-17(19(13)20)29-10-9-28-4/h11-12,25H,5-10H2,1-4H3,(H,22,26)
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n/an/a<1.00E+3n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160449
PNG
(US9040714, 171 | US9693992, 171)
Show SMILES COCCNC(=O)CCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(21)19-6-7-24-2)18(23)26-17-12(10)8-14(25-3)16(22)13(17)9-20/h8-9,22H,4-7H2,1-3H3,(H,19,21)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160450
PNG
(US9040714, 172 | US9693992, 172)
Show SMILES COc1cc2c(C)c(CCC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C19H21NO7/c1-11-12(3-4-16(22)20-5-7-26-8-6-20)19(24)27-18-13(11)9-15(25-2)17(23)14(18)10-21/h9-10,23H,3-8H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160458
PNG
(US9040714, 181 | US9693992, 181)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C21H25NO8/c1-13-14(3-4-18(24)22-5-7-28-8-6-22)21(26)30-20-15(13)11-17(29-10-9-27-2)19(25)16(20)12-23/h11-12,25H,3-10H2,1-2H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160459
PNG
(US9040714, 182 | US9693992, 182)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)N3CCN(C)CC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C22H28N2O7/c1-14-15(4-5-19(26)24-8-6-23(2)7-9-24)22(28)31-21-16(14)12-18(30-11-10-29-3)20(27)17(21)13-25/h12-13,27H,4-11H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160460
PNG
(US9040714, 184 | US9693992, 184)
Show SMILES COCCNC(=O)CCc1c(C)c2cc(OCCOC)c(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C20H25NO8/c1-12-13(4-5-17(23)21-6-7-26-2)20(25)29-19-14(12)10-16(28-9-8-27-3)18(24)15(19)11-22/h10-11,24H,4-9H2,1-3H3,(H,21,23)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160461
PNG
(US9040714, 185 | US9693992, 185)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)NCCN(C)C)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C21H28N2O7/c1-13-14(5-6-18(25)22-7-8-23(2)3)21(27)30-20-15(13)11-17(29-10-9-28-4)19(26)16(20)12-24/h11-12,26H,5-10H2,1-4H3,(H,22,25)
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n/an/a<100n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160462
PNG
(US9040714, 186 | US9693992, 186)
Show SMILES COCCOc1cc2c(C)c(CCC(=O)NCCN3CCOCC3)c(=O)oc2c(C=O)c1O
Show InChI InChI=1S/C23H30N2O8/c1-15-16(3-4-20(27)24-5-6-25-7-9-31-10-8-25)23(29)33-22-17(15)13-19(32-12-11-30-2)21(28)18(22)14-26/h13-14,28H,3-12H2,1-2H3,(H,24,27)
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n/an/a<1.00E+3n/a>1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160463
PNG
(US9040714, 192 | US9693992, 192)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCOCC3)c(C)c12
Show InChI InChI=1S/C19H21NO7/c1-11-12(3-4-16(23)20-5-7-26-8-6-20)19(24)27-18-13(10-21)14(22)9-15(25-2)17(11)18/h9-10,22H,3-8H2,1-2H3
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n/an/a<1.00E+3n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160464
PNG
(US9040714, 193 | US9693992, 193)
Show SMILES COc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C20H24N2O6/c1-12-13(4-5-17(25)22-8-6-21(2)7-9-22)20(26)28-19-14(11-23)15(24)10-16(27-3)18(12)19/h10-11,24H,4-9H2,1-3H3
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160465
PNG
(US9040714, 194 | US9693992, 194)
Show SMILES COCCNC(=O)CCc1c(C)c2c(OC)cc(O)c(C=O)c2oc1=O
Show InChI InChI=1S/C18H21NO7/c1-10-11(4-5-15(22)19-6-7-24-2)18(23)26-17-12(9-20)13(21)8-14(25-3)16(10)17/h8-9,21H,4-7H2,1-3H3,(H,19,22)
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n/an/a<100n/a<1.00E+4n/an/a7.530



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...


US Patent US9693992 (2017)


BindingDB Entry DOI: 10.7270/Q2CZ35BC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha


(Homo sapiens (Human))
BDBM160440
PNG
(US9040714, 154 | US9693992, 154)
Show SMILES COCCOc1cc(O)c(C=O)c2oc(=O)c(CCC(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C22H28N2O7/c1-14-15(4-5-19(27)24-8-6-23(2)7-9-24)22(28)31-21-16(13-25)17(26)12-18(20(14)21)30-11-10-29-3/h12-13,26H,4-11H2,1-3H3
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n/an/a<100n/an/an/an/a7.5n/a



MannKind Corporation

US Patent


Assay Description
A fusion protein comprising glutathione S transferase (GST) and human IRE-1alpha (GST-IRE-1alpha) obtained from a 500 ml baculovirus-infected insect ...


US Patent US9040714 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F3S
More data for this
Ligand-Target Pair