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60 similar compounds to monomer 187363

Compile data set for download or QSAR
Wt: 559.5
BDBM162320
Wt: 501.6
BDBM162321
Wt: 557.5
BDBM162322
Wt: 587.6
BDBM162323
Wt: 531.6
BDBM162324
Wt: 572.6
BDBM162325
Wt: 516.6
BDBM162326
Wt: 503.5
BDBM162310
Wt: 503.5
BDBM162311
Wt: 559.5
BDBM162312
Wt: 559.5
BDBM162313
Wt: 517.5
BDBM162314
Wt: 473.5
BDBM162315
Wt: 529.5
BDBM162316
Wt: 543.5
BDBM162317
Displayed 1 to 15 (of 60 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 162320,162321,162322,162323,162324,162325,162326,162310,162311,162312,162313,162314,162315,162316,162317   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162310
PNG
(US9051313, 1)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCOCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H25N9O2S/c34-23(28-21-12-36-24(29-21)22-30-27-14-33(22)16-3-4-16)17-9-19(32-11-18(26-13-32)15-1-2-15)20(10-25-17)31-5-7-35-8-6-31/h9-16H,1-8H2,(H,28,34)
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n/an/a 1.44n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162323
PNG
(US9051313, 14)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-22(38)24-34-21(12-41-24)33-23(39)17-9-19(37-11-18(31-13-37)16-3-4-16)20(10-30-17)36-7-5-25(2,40)6-8-36/h9-16,40H,3-8H2,1-2H3,(H,33,39)/t15-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162312
PNG
(US9051313, 3)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCOCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-14(24(25,26)27)36-13-30-33-21(36)23-32-20(11-39-23)31-22(37)16-8-18(35-10-17(29-12-35)15-2-3-15)19(9-28-16)34-4-6-38-7-5-34/h8-15H,2-7H2,1H3,(H,31,37)/t14-/m0/s1
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n/an/a 2.62n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162313
PNG
(US9051313, 4)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CC(C)(O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-13(24(25,26)27)36-12-30-33-20(36)22-32-19(8-39-22)31-21(37)15-5-17(34-7-16(29-11-34)14-3-4-14)18(6-28-15)35-9-23(2,38)10-35/h5-8,11-14,38H,3-4,9-10H2,1-2H3,(H,31,37)/t13-/m0/s1
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n/an/a 1.69n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162314
PNG
(US9051313, 5)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N(C)C)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N9OS/c1-12(22(23,24)25)34-11-28-31-19(34)21-30-18(9-36-21)29-20(35)14-6-16(17(7-26-14)32(2)3)33-8-15(27-10-33)13-4-5-13/h6-13H,4-5H2,1-3H3,(H,29,35)/t12-/m0/s1
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n/an/a 1.88n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162315
PNG
(US9051313, 6)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C23H23N9OS/c33-22(27-20-11-34-23(28-20)21-29-26-13-32(21)15-4-5-15)16-8-18(19(9-24-16)30-6-1-7-30)31-10-17(25-12-31)14-2-3-14/h8-15H,1-7H2,(H,27,33)
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n/an/a 2.40n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162316
PNG
(US9051313, 7)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N9OS/c1-13(23(24,25)26)35-12-29-32-20(35)22-31-19(10-37-22)30-21(36)15-7-17(18(8-27-15)33-5-2-6-33)34-9-16(28-11-34)14-3-4-14/h7-14H,2-6H2,1H3,(H,30,36)/t13-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162317
PNG
(US9051313, 8)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9OS/c1-14(24(25,26)27)36-13-30-33-21(36)23-32-20(11-38-23)31-22(37)16-8-18(19(9-28-16)34-6-2-3-7-34)35-10-17(29-12-35)15-4-5-15/h8-15H,2-7H2,1H3,(H,31,37)/t14-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162320
PNG
(US9051313, 11)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(O)C2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N9O2S/c1-13(24(25,26)27)36-12-30-33-21(36)23-32-20(10-39-23)31-22(38)16-6-18(35-9-17(29-11-35)14-2-3-14)19(7-28-16)34-5-4-15(37)8-34/h6-7,9-15,37H,2-5,8H2,1H3,(H,31,38)/t13-,15?/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162324
PNG
(US9051313, 15)
Show SMILES CC1(O)CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C26H29N9O2S/c1-26(37)6-8-33(9-7-26)21-11-27-18(10-20(21)34-12-19(28-14-34)16-2-3-16)24(36)30-22-13-38-25(31-22)23-32-29-15-35(23)17-4-5-17/h10-17,37H,2-9H2,1H3,(H,30,36)
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n/an/a 2.5n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162325
PNG
(US9051313, 16)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(C)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N10OS/c1-15(25(26,27)28)38-14-31-34-22(38)24-33-21(12-40-24)32-23(39)17-9-19(37-11-18(30-13-37)16-3-4-16)20(10-29-17)36-7-5-35(2)6-8-36/h9-16H,3-8H2,1-2H3,(H,32,39)/t15-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162326
PNG
(US9051313, 17)
Show SMILES CN1CCN(CC1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C25H28N10OS/c1-32-6-8-33(9-7-32)21-11-26-18(10-20(21)34-12-19(27-14-34)16-2-3-16)24(36)29-22-13-37-25(30-22)23-31-28-15-35(23)17-4-5-17/h10-17H,2-9H2,1H3,(H,29,36)
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n/an/a 3.10n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162321
PNG
(US9051313, 12)
Show SMILES O=C(Nc1csc(n1)-c1nncn1C1CC1)c1cc(c(cn1)N1CCCCC1)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C25H27N9OS/c35-24(29-22-13-36-25(30-22)23-31-28-15-34(23)17-6-7-17)18-10-20(33-12-19(27-14-33)16-4-5-16)21(11-26-18)32-8-2-1-3-9-32/h10-17H,1-9H2,(H,29,35)
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n/an/a 2n/an/an/an/an/an/a



Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162322
PNG
(US9051313, 13)
Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCCCC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N9OS/c1-15(25(26,27)28)37-14-31-34-22(37)24-33-21(12-39-24)32-23(38)17-9-19(36-11-18(30-13-36)16-5-6-16)20(10-29-17)35-7-3-2-4-8-35/h9-16H,2-8H2,1H3,(H,32,38)/t15-/m0/s1
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair
Apoptosis Signal-regulating Kinase 1 (ASK1)


(Homo sapiens (Human))
BDBM162311
PNG
(US9051313, 2)
Show SMILES CC1(O)CN(C1)c1cnc(cc1-n1cnc(c1)C1CC1)C(=O)Nc1csc(n1)-c1nncn1C1CC1
Show InChI InChI=1S/C24H25N9O2S/c1-24(35)10-32(11-24)19-7-25-16(6-18(19)31-8-17(26-12-31)14-2-3-14)22(34)28-20-9-36-23(29-20)21-30-27-13-33(21)15-4-5-15/h6-9,12-15,35H,2-5,10-11H2,1H3,(H,28,34)
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Gildead Sciences, Inc.

US Patent


Assay Description
The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...


US Patent US9051313 (2015)


BindingDB Entry DOI: 10.7270/Q21N7ZVX
More data for this
Ligand-Target Pair