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2 similar compounds to monomer 164455

Compile data set for download or QSAR
Wt: 383.4
BDBM50302901
Wt: 374.3
BDBM164433

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50302901,164433   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164433
PNG
(US9066954, 84)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnn[nH]3)ccnc2c1
Show InChI InChI=1S/C17H14N10O/c1-28-10-6-13-17(20-7-10)12(4-5-18-13)19-9-16-24-23-15-3-2-11(25-27(15)16)14-8-21-26-22-14/h2-8H,9H2,1H3,(H,18,19)(H,21,22,26)
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US Patent
26.1 -10.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50302901
PNG
(7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H17N7O/c1-29-15-11-18-21(24-12-15)17(9-10-22-18)23-13-20-26-25-19-8-7-16(27-28(19)20)14-5-3-2-4-6-14/h2-12H,13H2,1H3,(H,22,23)
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Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassay


Bioorg Med Chem Lett 19: 6307-12 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.096
BindingDB Entry DOI: 10.7270/Q2DV1JZH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50302901
PNG
(7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H17N7O/c1-29-15-11-18-21(24-12-15)17(9-10-22-18)23-13-20-26-25-19-8-7-16(27-28(19)20)14-5-3-2-4-6-14/h2-12H,13H2,1H3,(H,22,23)
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Article
PubMed
n/an/a 4.10E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPH


Bioorg Med Chem Lett 19: 6307-12 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.096
BindingDB Entry DOI: 10.7270/Q2DV1JZH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50302901
PNG
(7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H17N7O/c1-29-15-11-18-21(24-12-15)17(9-10-22-18)23-13-20-26-25-19-8-7-16(27-28(19)20)14-5-3-2-4-6-14/h2-12H,13H2,1H3,(H,22,23)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


Bioorg Med Chem Lett 19: 6307-12 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.096
BindingDB Entry DOI: 10.7270/Q2DV1JZH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50302901
PNG
(7-methoxy-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyrid...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H17N7O/c1-29-15-11-18-21(24-12-15)17(9-10-22-18)23-13-20-26-25-19-8-7-16(27-28(19)20)14-5-3-2-4-6-14/h2-12H,13H2,1H3,(H,22,23)
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CYP3A4


Bioorg Med Chem Lett 19: 6307-12 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.096
BindingDB Entry DOI: 10.7270/Q2DV1JZH
More data for this
Ligand-Target Pair