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25 similar compounds to monomer 167604

Compile data set for download or QSAR
Wt: 420.5
BDBM167676
Wt: 351.4
BDBM167677
Wt: 438.9
BDBM167678
Wt: 391.5
BDBM167603
Wt: 398.5
BDBM167605
Wt: 361.4
BDBM167607
Wt: 433.5
BDBM167609
Wt: 411.5
BDBM167610
Wt: 431.9
BDBM167611
Wt: 411.5
BDBM167618
Wt: 424.9
BDBM167557
Wt: 439.9
BDBM167647
Wt: 424.9
BDBM167558
Wt: 425.9
BDBM167563
Wt: 397.5
BDBM167651
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 167676,167677,167678,167603,167605,167607,167609,167610,167611,167618,167557,167647,167558,167563,167651   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167557
PNG
(US9073922, 42 | US9796708, Example 42)
Show SMILES Clc1ccc(NCC2CCNCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C23H29ClN6/c24-19-1-2-21(28-14-15-3-8-25-9-4-15)30-22(19)17-7-12-27-23-18(17)13-20(29-23)16-5-10-26-11-6-16/h1-2,7,12-13,15-16,25-26H,3-6,8-11,14H2,(H,27,29)(H,28,30)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167678
PNG
(US9073922, 165 | US9796708, Example 165)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCNCC2)ccc1Cl
Show InChI InChI=1S/C24H31ClN6/c1-31-12-7-17(8-13-31)21-14-19-18(6-11-27-24(19)29-21)23-20(25)2-3-22(30-23)28-15-16-4-9-26-10-5-16/h2-3,6,11,14,16-17,26H,4-5,7-10,12-13,15H2,1H3,(H,27,29)(H,28,30)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167563
PNG
(US9073922, 48 | US9796708, Example 48)
Show SMILES Clc1ccc(NCC2CCOCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C23H28ClN5O/c24-19-1-2-21(27-14-15-6-11-30-12-7-15)29-22(19)17-5-10-26-23-18(17)13-20(28-23)16-3-8-25-9-4-16/h1-2,5,10,13,15-16,25H,3-4,6-9,11-12,14H2,(H,26,28)(H,27,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167603
PNG
(US9073922, 88 | US9796708, Example 88)
Show SMILES C(Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1)C1CCOCC1
Show InChI InChI=1S/C23H29N5O/c1-2-20(27-22(3-1)26-15-16-7-12-29-13-8-16)18-6-11-25-23-19(18)14-21(28-23)17-4-9-24-10-5-17/h1-3,6,11,14,16-17,24H,4-5,7-10,12-13,15H2,(H,25,28)(H,26,27)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167605
PNG
(US9073922, 91 | US9796708, Example 91)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccnc2)n1
Show InChI InChI=1S/C24H26N6/c1-30-12-8-18(9-13-30)22-14-20-19(7-11-26-24(20)29-22)21-5-2-6-23(28-21)27-16-17-4-3-10-25-15-17/h2-7,10-11,14-15,18H,8-9,12-13,16H2,1H3,(H,26,29)(H,27,28)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167607
PNG
(US9073922, 93 | US9796708, Example 93)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CC2)n1
Show InChI InChI=1S/C22H27N5/c1-27-11-8-16(9-12-27)20-13-18-17(7-10-23-22(18)26-20)19-3-2-4-21(25-19)24-14-15-5-6-15/h2-4,7,10,13,15-16H,5-6,8-9,11-12,14H2,1H3,(H,23,26)(H,24,25)
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n/an/a 34n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167609
PNG
(US9073922, 95 | US9796708, Example 95)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CCOC(C)(C)C2)n1
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n/an/a 150n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167610
PNG
(US9073922, 96 | US9796708, Example 96)
Show SMILES CN(Cc1ccccc1)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1
Show InChI InChI=1S/C26H29N5/c1-30-15-12-20(13-16-30)24-17-22-21(11-14-27-26(22)29-24)23-9-6-10-25(28-23)31(2)18-19-7-4-3-5-8-19/h3-11,14,17,20H,12-13,15-16,18H2,1-2H3,(H,27,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167611
PNG
(US9073922, 97 | US9796708, Example 97)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccc(Cl)c2)n1
Show InChI InChI=1S/C25H26ClN5/c1-31-12-9-18(10-13-31)23-15-21-20(8-11-27-25(21)30-23)22-6-3-7-24(29-22)28-16-17-4-2-5-19(26)14-17/h2-8,11,14-15,18H,9-10,12-13,16H2,1H3,(H,27,30)(H,28,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167618
PNG
(US9073922, 104 | US9796708, Example 104)
Show SMILES C[C@H](Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1)c1ccccc1
Show InChI InChI=1S/C26H29N5/c1-18(19-7-4-3-5-8-19)28-25-10-6-9-23(29-25)21-11-14-27-26-22(21)17-24(30-26)20-12-15-31(2)16-13-20/h3-11,14,17-18,20H,12-13,15-16H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167647
PNG
(US9073922, 134 | US9796708, Example 134)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCOCC2)ccc1Cl
Show InChI InChI=1S/C24H30ClN5O/c1-30-10-5-17(6-11-30)21-14-19-18(4-9-26-24(19)28-21)23-20(25)2-3-22(29-23)27-15-16-7-12-31-13-8-16/h2-4,9,14,16-17H,5-8,10-13,15H2,1H3,(H,26,28)(H,27,29)
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n/an/a 120n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167651
PNG
(US9073922, 138 | US9796708, Example 138)
Show SMILES C(Cc1ccccc1)Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C25H27N5/c1-2-5-18(6-3-1)9-15-27-24-8-4-7-22(29-24)20-12-16-28-25-21(20)17-23(30-25)19-10-13-26-14-11-19/h1-8,12,16-17,19,26H,9-11,13-15H2,(H,27,29)(H,28,30)
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n/an/a 33n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167676
PNG
(US9073922, 163 | US9796708, Example 163)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCN2CCOCC2)n1
Show InChI InChI=1S/C24H32N6O/c1-29-10-6-18(7-11-29)22-17-20-19(5-8-26-24(20)28-22)21-3-2-4-23(27-21)25-9-12-30-13-15-31-16-14-30/h2-5,8,17-18H,6-7,9-16H2,1H3,(H,25,27)(H,26,28)
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n/an/a 110n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167677
PNG
(US9073922, 164 | US9796708, Example 164)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCO)n1
Show InChI InChI=1S/C20H25N5O/c1-25-10-6-14(7-11-25)18-13-16-15(5-8-22-20(16)24-18)17-3-2-4-19(23-17)21-9-12-26/h2-5,8,13-14,26H,6-7,9-12H2,1H3,(H,21,23)(H,22,24)
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n/an/a 30n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167678
PNG
(US9073922, 165 | US9796708, Example 165)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCNCC2)ccc1Cl
Show InChI InChI=1S/C24H31ClN6/c1-31-12-7-17(8-13-31)21-14-19-18(6-11-27-24(19)29-21)23-20(25)2-3-22(30-23)28-15-16-4-9-26-10-5-16/h2-3,6,11,14,16-17,26H,4-5,7-10,12-13,15H2,1H3,(H,27,29)(H,28,30)
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n/an/a 450n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167557
PNG
(US9073922, 42 | US9796708, Example 42)
Show SMILES Clc1ccc(NCC2CCNCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C23H29ClN6/c24-19-1-2-21(28-14-15-3-8-25-9-4-15)30-22(19)17-7-12-27-23-18(17)13-20(29-23)16-5-10-26-11-6-16/h1-2,7,12-13,15-16,25-26H,3-6,8-11,14H2,(H,27,29)(H,28,30)
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n/an/a 550n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167558
PNG
(US9073922, 43 | US9796708, Example 43)
Show SMILES Clc1ccc(NCC2CCCNC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
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n/an/a 170n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167563
PNG
(US9073922, 48 | US9796708, Example 48)
Show SMILES Clc1ccc(NCC2CCOCC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C23H28ClN5O/c24-19-1-2-21(27-14-15-6-11-30-12-7-15)29-22(19)17-5-10-26-23-18(17)13-20(28-23)16-3-8-25-9-4-16/h1-2,5,10,13,15-16,25H,3-4,6-9,11-12,14H2,(H,26,28)(H,27,29)
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n/an/a 81n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167603
PNG
(US9073922, 88 | US9796708, Example 88)
Show SMILES C(Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1)C1CCOCC1
Show InChI InChI=1S/C23H29N5O/c1-2-20(27-22(3-1)26-15-16-7-12-29-13-8-16)18-6-11-25-23-19(18)14-21(28-23)17-4-9-24-10-5-17/h1-3,6,11,14,16-17,24H,4-5,7-10,12-13,15H2,(H,25,28)(H,26,27)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167605
PNG
(US9073922, 91 | US9796708, Example 91)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccnc2)n1
Show InChI InChI=1S/C24H26N6/c1-30-12-8-18(9-13-30)22-14-20-19(7-11-26-24(20)29-22)21-5-2-6-23(28-21)27-16-17-4-3-10-25-15-17/h2-7,10-11,14-15,18H,8-9,12-13,16H2,1H3,(H,26,29)(H,27,28)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167607
PNG
(US9073922, 93 | US9796708, Example 93)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CC2)n1
Show InChI InChI=1S/C22H27N5/c1-27-11-8-16(9-12-27)20-13-18-17(7-10-23-22(18)26-20)19-3-2-4-21(25-19)24-14-15-5-6-15/h2-4,7,10,13,15-16H,5-6,8-9,11-12,14H2,1H3,(H,23,26)(H,24,25)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167609
PNG
(US9073922, 95 | US9796708, Example 95)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCC2CCOC(C)(C)C2)n1
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167610
PNG
(US9073922, 96 | US9796708, Example 96)
Show SMILES CN(Cc1ccccc1)c1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1
Show InChI InChI=1S/C26H29N5/c1-30-15-12-20(13-16-30)24-17-22-21(11-14-27-26(22)29-24)23-9-6-10-25(28-23)31(2)18-19-7-4-3-5-8-19/h3-11,14,17,20H,12-13,15-16,18H2,1-2H3,(H,27,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167611
PNG
(US9073922, 97 | US9796708, Example 97)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCc2cccc(Cl)c2)n1
Show InChI InChI=1S/C25H26ClN5/c1-31-12-9-18(10-13-31)23-15-21-20(8-11-27-25(21)30-23)22-6-3-7-24(29-22)28-16-17-4-2-5-19(26)14-17/h2-8,11,14-15,18H,9-10,12-13,16H2,1H3,(H,27,30)(H,28,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167618
PNG
(US9073922, 104 | US9796708, Example 104)
Show SMILES C[C@H](Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCN(C)CC1)c1ccccc1
Show InChI InChI=1S/C26H29N5/c1-18(19-7-4-3-5-8-19)28-25-10-6-9-23(29-25)21-11-14-27-26-22(21)17-24(30-26)20-12-15-31(2)16-13-20/h3-11,14,17-18,20H,12-13,15-16H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167647
PNG
(US9073922, 134 | US9796708, Example 134)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCC2CCOCC2)ccc1Cl
Show InChI InChI=1S/C24H30ClN5O/c1-30-10-5-17(6-11-30)21-14-19-18(4-9-26-24(19)28-21)23-20(25)2-3-22(29-23)27-15-16-7-12-31-13-8-16/h2-4,9,14,16-17H,5-8,10-13,15H2,1H3,(H,26,28)(H,27,29)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167651
PNG
(US9073922, 138 | US9796708, Example 138)
Show SMILES C(Cc1ccccc1)Nc1cccc(n1)-c1ccnc2[nH]c(cc12)C1CCNCC1
Show InChI InChI=1S/C25H27N5/c1-2-5-18(6-3-1)9-15-27-24-8-4-7-22(29-24)20-12-16-28-25-21(20)17-23(30-25)19-10-13-26-14-11-19/h1-8,12,16-17,19,26H,9-11,13-15H2,(H,27,29)(H,28,30)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167676
PNG
(US9073922, 163 | US9796708, Example 163)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCN2CCOCC2)n1
Show InChI InChI=1S/C24H32N6O/c1-29-10-6-18(7-11-29)22-17-20-19(5-8-26-24(20)28-22)21-3-2-4-23(27-21)25-9-12-30-13-15-31-16-14-30/h2-5,8,17-18H,6-7,9-16H2,1H3,(H,25,27)(H,26,28)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (Human))
BDBM167677
PNG
(US9073922, 164 | US9796708, Example 164)
Show SMILES CN1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1cccc(NCCO)n1
Show InChI InChI=1S/C20H25N5O/c1-25-10-6-14(7-11-25)18-13-16-15(5-8-22-20(16)24-18)17-3-2-4-19(23-17)21-9-12-26/h2-5,8,13-14,26H,6-7,9-12H2,1H3,(H,21,23)(H,22,24)
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9796708 (2017)


BindingDB Entry DOI: 10.7270/Q2WD42P4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM167558
PNG
(US9073922, 43 | US9796708, Example 43)
Show SMILES Clc1ccc(NCC2CCCNC2)nc1-c1ccnc2[nH]c(cc12)C1CCNCC1
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AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9073922 (2015)


BindingDB Entry DOI: 10.7270/Q2CJ8C78
More data for this
Ligand-Target Pair