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5 similar compounds to monomer 7238

Compile data set for download or QSAR
Wt: 226.2
BDBM17020
Wt: 240.2
BDBM17029
Wt: 211.2
BDBM41079
Wt: 225.2
BDBM52926
Wt: 239.2
BDBM67638

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 17020,17029,41079,52926,67638   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM17020
PNG
((3Z)-5-hydroxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Show SMILES Oc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1
Show InChI InChI=1S/C13H10N2O2/c16-9-3-4-12-10(7-9)11(13(17)15-12)6-8-2-1-5-14-8/h1-7,14,16H,(H,15,17)/b11-6-
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Article
PubMed
n/an/a 340n/an/an/an/a7.222



Berlex Biosciences



Assay Description
The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...


Bioorg Med Chem Lett 17: 3814-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.071
BindingDB Entry DOI: 10.7270/Q25Q4TBB
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM17029
PNG
((3Z)-5-methoxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1
Show InChI InChI=1S/C14H12N2O2/c1-18-10-4-5-13-11(8-10)12(14(17)16-13)7-9-3-2-6-15-9/h2-8,15H,1H3,(H,16,17)/b12-7-
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PubMed
n/an/a 580n/an/an/an/a7.222



Berlex Biosciences



Assay Description
The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...


Bioorg Med Chem Lett 17: 3814-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.071
BindingDB Entry DOI: 10.7270/Q25Q4TBB
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM41079
PNG
((3Z)-3-(1H-imidazol-5-ylmethylene)oxindole | (3Z)-...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc[nH]1
Show InChI InChI=1S/C12H9N3O/c16-12-10(5-8-6-13-7-14-8)9-3-1-2-4-11(9)15-12/h1-7H,(H,13,14)(H,15,16)/b10-5-
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n/an/a 2.87E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2GX48ZN
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM41079
PNG
((3Z)-3-(1H-imidazol-5-ylmethylene)oxindole | (3Z)-...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc[nH]1
Show InChI InChI=1S/C12H9N3O/c16-12-10(5-8-6-13-7-14-8)9-3-1-2-4-11(9)15-12/h1-7H,(H,13,14)(H,15,16)/b10-5-
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PCBioAssay
n/an/a 8.78E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2H993M3
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52926
PNG
((3Z)-3-[(2-methyl-1H-imidazol-5-yl)methylene]oxind...)
Show SMILES Cc1ncc(C=C2C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C13H11N3O/c1-8-14-7-9(15-8)6-11-10-4-2-3-5-12(10)16-13(11)17/h2-7H,1H3,(H,14,15)(H,16,17)/b11-6-
KEGG

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PCBioAssay
n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM41079
PNG
((3Z)-3-(1H-imidazol-5-ylmethylene)oxindole | (3Z)-...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc[nH]1
Show InChI InChI=1S/C12H9N3O/c16-12-10(5-8-6-13-7-14-8)9-3-1-2-4-11(9)15-12/h1-7H,(H,13,14)(H,15,16)/b10-5-
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n/an/an/an/a 1.76E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2P55KXK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM41079
PNG
((3Z)-3-(1H-imidazol-5-ylmethylene)oxindole | (3Z)-...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc[nH]1
Show InChI InChI=1S/C12H9N3O/c16-12-10(5-8-6-13-7-14-8)9-3-1-2-4-11(9)15-12/h1-7H,(H,13,14)(H,15,16)/b10-5-
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n/an/an/an/a 2.99E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM52926
PNG
((3Z)-3-[(2-methyl-1H-imidazol-5-yl)methylene]oxind...)
Show SMILES Cc1ncc(C=C2C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C13H11N3O/c1-8-14-7-9(15-8)6-11-10-4-2-3-5-12(10)16-13(11)17/h2-7H,1H3,(H,14,15)(H,16,17)/b11-6-
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 33


(Homo sapiens (Human))
BDBM41079
PNG
((3Z)-3-(1H-imidazol-5-ylmethylene)oxindole | (3Z)-...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc[nH]1
Show InChI InChI=1S/C12H9N3O/c16-12-10(5-8-6-13-7-14-8)9-3-1-2-4-11(9)15-12/h1-7H,(H,13,14)(H,15,16)/b10-5-
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n/an/an/an/a 7.94E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2B27SRF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 33


(Homo sapiens (Human))
BDBM67638
PNG
((3Z)-3-[(2-ethyl-1H-imidazol-5-yl)methylene]oxindo...)
Show SMILES CCc1ncc(C=C2C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C14H13N3O/c1-2-13-15-8-9(16-13)7-11-10-5-3-4-6-12(10)17-14(11)18/h3-8H,2H2,1H3,(H,15,16)(H,17,18)/b11-7-
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n/an/an/an/a 5.25E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2B27SRF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 33


(Homo sapiens (Human))
BDBM52926
PNG
((3Z)-3-[(2-methyl-1H-imidazol-5-yl)methylene]oxind...)
Show SMILES Cc1ncc(C=C2C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C13H11N3O/c1-8-14-7-9(15-8)6-11-10-4-2-3-5-12(10)16-13(11)17/h2-7H,1H3,(H,14,15)(H,16,17)/b11-6-
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n/an/an/an/a 3.42E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2B27SRF
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52926
PNG
((3Z)-3-[(2-methyl-1H-imidazol-5-yl)methylene]oxind...)
Show SMILES Cc1ncc(C=C2C(=O)Nc3ccccc23)[nH]1
Show InChI InChI=1S/C13H11N3O/c1-8-14-7-9(15-8)6-11-10-4-2-3-5-12(10)16-13(11)17/h2-7H,1H3,(H,14,15)(H,16,17)/b11-6-
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair