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2 similar compounds to monomer 17685

Compile data set for download or QSAR
Wt: 514.4
BDBM17683
Wt: 540.5
BDBM17684

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17683,17684   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17684
PNG
(2-aminobenzimidazole, 9 | N-methyl-4-({2-[(3-{[(2R...)
Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(c(OC[C@H]5CCCN5C)c4)C(F)(F)F)[nH]c3c2)ccn1
Show InChI InChI=1S/C27H27F3N6O3/c1-31-25(37)23-14-19(9-10-32-23)39-18-6-8-21-22(13-18)35-26(34-21)33-16-5-7-20(27(28,29)30)24(12-16)38-15-17-4-3-11-36(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,31,37)(H2,33,34,35)/t17-/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
2 -11.7n/an/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
BindingDB Entry DOI: 10.7270/Q21V5C74
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17683
PNG
(2-aminobenzimidazole, 8 | 4-{[2-({3-[2-(dimethylam...)
Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(c(OCCN(C)C)c4)C(F)(F)F)[nH]c3c2)ccn1
Show InChI InChI=1S/C25H25F3N6O3/c1-29-23(35)21-14-17(8-9-30-21)37-16-5-7-19-20(13-16)33-24(32-19)31-15-4-6-18(25(26,27)28)22(12-15)36-11-10-34(2)3/h4-9,12-14H,10-11H2,1-3H3,(H,29,35)(H2,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
3 -11.5n/an/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
BindingDB Entry DOI: 10.7270/Q21V5C74
More data for this
Ligand-Target Pair