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2 similar compounds to monomer 17692

Compile data set for download or QSAR
Wt: 488.9
BDBM17690
Wt: 496.0
BDBM17693

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17690,17693   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17690
PNG
(2-aminobenzimidazole, 15 | N-{4-chloro-3-[(4-methy...)
Show SMILES CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ncnc6[nH]ccc56)cc4[nH]3)ccc2Cl)CC1
Show InChI InChI=1S/C25H25ClN8O/c1-33-8-10-34(11-9-33)14-16-12-17(2-4-20(16)26)30-25-31-21-5-3-18(13-22(21)32-25)35-24-19-6-7-27-23(19)28-15-29-24/h2-7,12-13,15H,8-11,14H2,1H3,(H,27,28,29)(H2,30,31,32)
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Similars

Article
PubMed
17 -10.5n/an/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
BindingDB Entry DOI: 10.7270/Q21V5C74
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM17693
PNG
(2-aminobenzimidazole, 18 | N-{4-chloro-3-[(4-methy...)
Show SMILES CSc1nccc(Oc2ccc3nc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)[nH]c3c2)n1
Show InChI InChI=1S/C24H26ClN7OS/c1-31-9-11-32(12-10-31)15-16-13-17(3-5-19(16)25)27-23-28-20-6-4-18(14-21(20)29-23)33-22-7-8-26-24(30-22)34-2/h3-8,13-14H,9-12,15H2,1-2H3,(H2,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
128 -9.30n/an/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 50: 4351-4373 (2007)


Article DOI: 10.1021/jm070034i
BindingDB Entry DOI: 10.7270/Q21V5C74
More data for this
Ligand-Target Pair