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1 similar compounds to monomer 182774

Compile data set for download or QSAR
Wt: 383.4
BDBM182798

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 182798   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM182798
PNG
(US9145414, 161)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc3ccccc3s2)n1
Show InChI InChI=1/C18H21N7OS/c19-11-6-2-3-7-12(11)21-18-23-17(15(16(20)26)24-25-18)22-14-9-10-5-1-4-8-13(10)27-14/h1,4-5,8-9,11-12H,2-3,6-7,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,12+/s2
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.280n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...


US Patent US9145414 (2015)


BindingDB Entry DOI: 10.7270/Q2513X18
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM182798
PNG
(US9145414, 161)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc3ccccc3s2)n1
Show InChI InChI=1/C18H21N7OS/c19-11-6-2-3-7-12(11)21-18-23-17(15(16(20)26)24-25-18)22-14-9-10-5-1-4-8-13(10)27-14/h1,4-5,8-9,11-12H,2-3,6-7,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,12+/s2
PDB

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Similars

US Patent
n/an/a 420n/an/an/an/a7.425



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent publicat...


US Patent US9145414 (2015)


BindingDB Entry DOI: 10.7270/Q2513X18
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM182798
PNG
(US9145414, 161)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc3ccccc3s2)n1
Show InChI InChI=1/C18H21N7OS/c19-11-6-2-3-7-12(11)21-18-23-17(15(16(20)26)24-25-18)22-14-9-10-5-1-4-8-13(10)27-14/h1,4-5,8-9,11-12H,2-3,6-7,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,12+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>2.00E+3n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
Conditions for assaying the in vitro inhibitory activity of the compound against KDR kinase activity were set with reference to the statement in the ...


US Patent US9145414 (2015)


BindingDB Entry DOI: 10.7270/Q2513X18
More data for this
Ligand-Target Pair