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5 similar compounds to monomer 184556

Compile data set for download or QSAR
Wt: 571.5
BDBM184554
Wt: 553.5
BDBM184555
Wt: 571.5
BDBM184557
Purchase
Wt: 553.5
BDBM184558
Wt: 553.5
BDBM184559

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 184554,184555,184557,184558,184559   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM184559
PNG
(US9150579, A)
Show SMILES CC(C)Oc1ccc(cc1F)-c1nn(C(C)c2oc3ccccc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Show InChI InChI=1/C31H25F2N5O3/c1-16(2)40-24-12-11-19(14-22(24)33)27-26-30(34)35-15-36-31(26)38(37-27)17(3)29-25(18-7-6-8-20(32)13-18)28(39)21-9-4-5-10-23(21)41-29/h4-17H,1-3H3,(H2,34,35,36)
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US Patent
n/an/a 37.3n/an/an/an/an/a25



Rhizen Pharmaceuticals SA

US Patent


Assay Description
The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...


US Patent US9150579 (2015)


BindingDB Entry DOI: 10.7270/Q26T0KD5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM184555
PNG
(US9150579, A1)
Show SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccccc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Show InChI InChI=1/C31H25F2N5O3/c1-16(2)40-24-12-11-19(14-22(24)33)27-26-30(34)35-15-36-31(26)38(37-27)17(3)29-25(18-7-6-8-20(32)13-18)28(39)21-9-4-5-10-23(21)41-29/h4-17H,1-3H3,(H2,34,35,36)/t17-/s2
PDB
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US Patent
n/an/a 13.8n/an/an/an/an/a25



Rhizen Pharmaceuticals SA

US Patent


Assay Description
The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...


US Patent US9150579 (2015)


BindingDB Entry DOI: 10.7270/Q26T0KD5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM184557
PNG
(US9150579, B2)
Show SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Show InChI InChI=1/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/s2
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PC cid
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US Patent
n/an/a 1.45E+3n/an/an/an/an/a25



Rhizen Pharmaceuticals SA

US Patent


Assay Description
The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...


US Patent US9150579 (2015)


BindingDB Entry DOI: 10.7270/Q26T0KD5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM184554
PNG
(US9150579, B)
Show SMILES CC(C)Oc1ccc(cc1F)-c1nn(C(C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Show InChI InChI=1/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)
PDB
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US Patent
n/an/a 24.9n/an/an/an/an/a25



Rhizen Pharmaceuticals SA

US Patent


Assay Description
The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...


US Patent US9150579 (2015)


BindingDB Entry DOI: 10.7270/Q26T0KD5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM184558
PNG
(US9150579, A2)
Show SMILES CC(C)Oc1ccc(cc1F)-c1nn([C@H](C)c2oc3ccccc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Show InChI InChI=1/C31H25F2N5O3/c1-16(2)40-24-12-11-19(14-22(24)33)27-26-30(34)35-15-36-31(26)38(37-27)17(3)29-25(18-7-6-8-20(32)13-18)28(39)21-9-4-5-10-23(21)41-29/h4-17H,1-3H3,(H2,34,35,36)/t17-/s2
PDB
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KEGG

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UniChem

Similars

US Patent
n/an/a>1.00E+4n/an/an/an/an/a25



Rhizen Pharmaceuticals SA

US Patent


Assay Description
The homogenous time resolved fluorescence (HTRF) assay allows detection of 3,4,5-triphosphate (PIP3) formed as a result of phosphorylation of phosp...


US Patent US9150579 (2015)


BindingDB Entry DOI: 10.7270/Q26T0KD5
More data for this
Ligand-Target Pair