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15 similar compounds to monomer 1987

Compile data set for download or QSAR
Wt: 282.3
BDBM1980
Wt: 282.3
BDBM1983
Wt: 296.3
BDBM1984
Wt: 296.3
BDBM1985
Wt: 282.3
BDBM1988
Wt: 278.3
BDBM1992
Wt: 240.2
BDBM1976
Purchase
Wt: 254.2
BDBM1977
Purchase
Wt: 239.2
BDBM1978
Wt: 254.2
BDBM1979
Wt: 268.3
BDBM1981
Wt: 268.3
BDBM1982
Wt: 255.2
BDBM1989
Wt: 253.2
BDBM1991
Wt: 269.2
BDBM1993

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 1980,1983,1984,1985,1988,1992,1976,1977,1978,1979,1981,1982,1989,1991,1993   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1976
PNG
(13-amino-9-methyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8...)
Show SMILES CN1c2ccccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C14H12N2O2/c1-16-11-4-2-3-5-13(11)18-12-7-6-9(15)8-10(12)14(16)17/h2-8H,15H2,1H3
PDB
MMDB

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 180n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1993
PNG
(13-hydroxy-5,7,9-trimethyl-2-oxa-9-azatricyclo[9.4...)
Show SMILES CN1c2c(C)cc(C)cc2Oc2ccc(O)cc2C1=O
Show InChI InChI=1S/C16H15NO3/c1-9-6-10(2)15-14(7-9)20-13-5-4-11(18)8-12(13)16(19)17(15)3/h4-8,18H,1-3H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 63n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1978
PNG
(5,9-dimethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pen...)
Show SMILES CN1c2ccc(C)cc2Oc2ccccc2C1=O
Show InChI InChI=1S/C15H13NO2/c1-10-7-8-12-14(9-10)18-13-6-4-3-5-11(13)15(17)16(12)2/h3-9H,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
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PC sid
UniChem

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Article
PubMed
n/an/a 600n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1979
PNG
(13-amino-5,9-dimethyl-2-oxa-9-azatricyclo[9.4.0.0^...)
Show SMILES CN1c2ccc(C)cc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C15H14N2O2/c1-9-3-5-12-14(7-9)19-13-6-4-10(16)8-11(13)15(18)17(12)2/h3-8H,16H2,1-2H3
PDB
MMDB

B.MOAD
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PC sid
UniChem

Patents


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Article
PubMed
n/an/a 30n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1980
PNG
(13-amino-5-methyl-9-propyl-2-oxa-9-azatricyclo[9.4...)
Show SMILES CCCN1c2ccc(C)cc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C17H18N2O2/c1-3-8-19-14-6-4-11(2)9-16(14)21-15-7-5-12(18)10-13(15)17(19)20/h4-7,9-10H,3,8,18H2,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 130n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1981
PNG
(13-amino-9-ethyl-6-methyl-2-oxa-9-azatricyclo[9.4....)
Show SMILES CCN1c2cc(C)ccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C16H16N2O2/c1-3-18-13-8-10(2)4-6-15(13)20-14-7-5-11(17)9-12(14)16(18)19/h4-9H,3,17H2,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 240n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1982
PNG
(13-amino-9-ethyl-7-methyl-2-oxa-9-azatricyclo[9.4....)
Show SMILES CCN1c2c(C)cccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C16H16N2O2/c1-3-18-15-10(2)5-4-6-14(15)20-13-8-7-11(17)9-12(13)16(18)19/h4-9H,3,17H2,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 60n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1983
PNG
(13-amino-7-methyl-9-propyl-2-oxa-9-azatricyclo[9.4...)
Show SMILES CCCN1c2c(C)cccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C17H18N2O2/c1-3-9-19-16-11(2)5-4-6-15(16)21-14-8-7-12(18)10-13(14)17(19)20/h4-8,10H,3,9,18H2,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 260n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1984
PNG
(13-amino-5,6-dimethyl-9-propyl-2-oxa-9-azatricyclo...)
Show SMILES CCCN1c2cc(C)c(C)cc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C18H20N2O2/c1-4-7-20-15-8-11(2)12(3)9-17(15)22-16-6-5-13(19)10-14(16)18(20)21/h5-6,8-10H,4,7,19H2,1-3H3
PDB
MMDB

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PC sid
UniChem

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Article
PubMed
n/an/a 165n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1985
PNG
(13-amino-6,7-dimethyl-9-propyl-2-oxa-9-azatricyclo...)
Show SMILES CCCN1c2c(C)c(C)ccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C18H20N2O2/c1-4-9-20-17-12(3)11(2)5-7-16(17)22-15-8-6-13(19)10-14(15)18(20)21/h5-8,10H,4,9,19H2,1-3H3
PDB
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PC sid
UniChem

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Article
PubMed
n/an/a 670n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1988
PNG
(13-amino-9-ethyl-5,7-dimethyl-2-oxa-9-azatricyclo[...)
Show SMILES CCN1c2c(C)cc(C)cc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C17H18N2O2/c1-4-19-16-11(3)7-10(2)8-15(16)21-14-6-5-12(18)9-13(14)17(19)20/h5-9H,4,18H2,1-3H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 43n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1989
PNG
(13-hydroxy-5,9-dimethyl-2-oxa-9-azatricyclo[9.4.0....)
Show SMILES CN1c2ccc(C)cc2Oc2ccc(O)cc2C1=O
Show InChI InChI=1S/C15H13NO3/c1-9-3-5-12-14(7-9)19-13-6-4-10(17)8-11(13)15(18)16(12)2/h3-8,17H,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 640n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1991
PNG
(5,7,9-trimethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]...)
Show SMILES CN1c2c(C)cc(C)cc2Oc2ccccc2C1=O
Show InChI InChI=1S/C16H15NO2/c1-10-8-11(2)15-14(9-10)19-13-7-5-4-6-12(13)16(18)17(15)3/h4-9H,1-3H3
PDB
MMDB

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 57n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1992
PNG
(5,7,9-trimethyl-10-oxo-2-oxa-9-azatricyclo[9.4.0.0...)
Show SMILES CN1c2c(C)cc(C)cc2Oc2ccc(cc2C1=O)C#N
Show InChI InChI=1S/C17H14N2O2/c1-10-6-11(2)16-15(7-10)21-14-5-4-12(9-18)8-13(14)17(20)19(16)3/h4-8H,1-3H3
PDB
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Article
PubMed
n/an/a 50n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1977
PNG
(13-amino-9-ethyl-2-oxa-9-azatricyclo[9.4.0.0^{3,8}...)
Show SMILES CCN1c2ccccc2Oc2ccc(N)cc2C1=O
Show InChI InChI=1S/C15H14N2O2/c1-2-17-12-5-3-4-6-14(12)19-13-8-7-10(16)9-11(13)15(17)18/h3-9H,2,16H2,1H3
PDB
MMDB

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 145n/an/an/an/a7.822



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 35: 1887-97 (1992)


Article DOI: 10.1021/jm00088a027
BindingDB Entry DOI: 10.7270/Q2ST7N0J
More data for this
Ligand-Target Pair