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6 similar compounds to monomer 22904

Compile data set for download or QSAR
Wt: 125.1
BDBM22905
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Wt: 125.1
BDBM81972
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Wt: 139.1
BDBM81541
Wt: 139.1
BDBM81543
Wt: 139.1
BDBM50034706
Wt: 139.1
BDBM50034711

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 22905,81972,81541,81543,50034706,50034711   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM81541
PNG
(CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)
Show SMILES CC(N)C(C)c1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)
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0.0300n/an/an/an/an/an/an/an/a



Queen's Medical Centre

Curated by PDSP Ki Database




Biochem Soc Trans 20: 122-5 (1992)


BindingDB Entry DOI: 10.7270/Q2RX99KH
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM81543
PNG
(Alpha-Dimethylhistane-alpha | CAS_195960 | NSC_195...)
Show SMILES CNC(C)Cc1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-6(8-2)3-7-4-9-5-10-7/h4-6,8H,3H2,1-2H3,(H,9,10)
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0.200n/an/an/an/an/an/an/an/a



Queen's Medical Centre

Curated by PDSP Ki Database




Biochem Soc Trans 20: 122-5 (1992)


BindingDB Entry DOI: 10.7270/Q2RX99KH
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM81541
PNG
(CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)
Show SMILES CC(N)C(C)c1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)
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0.200n/an/an/an/an/an/an/an/a



Queen's Medical Centre

Curated by PDSP Ki Database




Biochem Soc Trans 20: 122-5 (1992)


BindingDB Entry DOI: 10.7270/Q2RX99KH
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50034711
PNG
((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Show SMILES C[C@@H](N)[C@H](C)c1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)/t5-,6+/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding afinity against Histamine H3 receptor


J Med Chem 38: 1593-9 (1995)


Article DOI: 10.1021/jm00010a003
BindingDB Entry DOI: 10.7270/Q2BK1BC1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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9n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation


J Med Chem 35: 3474-82 (1992)


Article DOI: 10.1021/jm00097a005
BindingDB Entry DOI: 10.7270/Q2445N3B
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50034706
PNG
((1R,2R)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Show SMILES C[C@@H](N)[C@@H](C)c1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)/t5-,6-/m1/s1
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11n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Binding afinity against Histamine H3 receptor


J Med Chem 38: 1593-9 (1995)


Article DOI: 10.1021/jm00010a003
BindingDB Entry DOI: 10.7270/Q2BK1BC1
More data for this
Ligand-Target Pair
HRH3


(RAT)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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11n/an/an/an/an/an/an/an/a



Unité 109

Curated by PDSP Ki Database




Invest Radiol -2 (1988)


BindingDB Entry DOI: 10.7270/Q22R3Q5W
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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14.3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined


Bioorg Med Chem Lett 2: 181-184 (1992)


Article DOI: 10.1016/S0960-894X(01)80446-7
BindingDB Entry DOI: 10.7270/Q24X588Z
More data for this
Ligand-Target Pair
HRH3


(RAT)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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50n/an/an/an/an/an/an/an/a



U. 109

Curated by PDSP Ki Database




J Pharmacol Exp Ther 271: 452-9 (1994)


BindingDB Entry DOI: 10.7270/Q23X8556
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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52n/an/an/an/an/an/an/an/a



Unité 109

Curated by PDSP Ki Database




Invest Radiol -2 (1988)


BindingDB Entry DOI: 10.7270/Q22R3Q5W
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22905
PNG
((2S)-1-(1H-imidazol-5-yl)propan-2-amine | (S)-alph...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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63n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam



Assay Description
Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...


J Pharmacol Exp Ther 314: 1310-21 (2005)


Article DOI: 10.1124/jpet.105.087965
BindingDB Entry DOI: 10.7270/Q2KD1W6V
More data for this
Ligand-Target Pair
HRH3


(RAT)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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77n/an/an/an/an/an/an/an/a



U. 109

Curated by PDSP Ki Database




J Pharmacol Exp Ther 271: 452-9 (1994)


BindingDB Entry DOI: 10.7270/Q23X8556
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM81543
PNG
(Alpha-Dimethylhistane-alpha | CAS_195960 | NSC_195...)
Show SMILES CNC(C)Cc1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-6(8-2)3-7-4-9-5-10-7/h4-6,8H,3H2,1-2H3,(H,9,10)
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270n/an/an/an/an/an/an/an/a



Queen's Medical Centre

Curated by PDSP Ki Database




Biochem Soc Trans 20: 122-5 (1992)


BindingDB Entry DOI: 10.7270/Q2RX99KH
More data for this
Ligand-Target Pair
HRH3


(RAT)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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470n/an/an/an/an/an/an/an/a



U. 109

Curated by PDSP Ki Database




J Pharmacol Exp Ther 271: 452-9 (1994)


BindingDB Entry DOI: 10.7270/Q23X8556
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM81541
PNG
(CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)
Show SMILES CC(N)C(C)c1cnc[nH]1
Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)
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1.80E+3n/an/an/an/an/an/an/an/a



Queen's Medical Centre

Curated by PDSP Ki Database




Biochem Soc Trans 20: 122-5 (1992)


BindingDB Entry DOI: 10.7270/Q2RX99KH
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22905
PNG
((2S)-1-(1H-imidazol-5-yl)propan-2-amine | (S)-alph...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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3.98E+3n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam



Assay Description
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...


J Pharmacol Exp Ther 314: 1310-21 (2005)


Article DOI: 10.1124/jpet.105.087965
BindingDB Entry DOI: 10.7270/Q2KD1W6V
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Universit£ Paris 7

Curated by ChEMBL


Assay Description
Inhibition of PAF-induced rabbit platelet aggregation


J Med Chem 36: 990-1000 (1993)


Article DOI: 10.1021/jm00060a006
BindingDB Entry DOI: 10.7270/Q2MC90NX
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes


Bioorg Med Chem Lett 3: 1493-1498 (1993)


Article DOI: 10.1016/S0960-894X(00)80005-0
BindingDB Entry DOI: 10.7270/Q2H132H9
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM81972
PNG
((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro


Bioorg Med Chem Lett 3: 1499-1504 (1993)


Article DOI: 10.1016/S0960-894X(00)80006-2
BindingDB Entry DOI: 10.7270/Q2CC115V
More data for this
Ligand-Target Pair