BindingDB logo
myBDB logout

7 similar compounds to monomer 25849

Compile data set for download or QSAR
Wt: 268.3
BDBM25850
Wt: 252.3
BDBM25848
Wt: 282.3
BDBM50178536
Wt: 296.3
BDBM50178543
Wt: 282.3
BDBM50299626
Wt: 284.3
BDBM50299627
Wt: 284.3
BDBM50299636

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 25850,25848,50178536,50178543,50299626,50299627,50299636   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50178536
PNG
(4-(5-(4-methoxyphenyl)thiophen-2-yl)phenol | CHEMB...)
Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H14O2S/c1-19-15-8-4-13(5-9-15)17-11-10-16(20-17)12-2-6-14(18)7-3-12/h2-11,18H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.10n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates


Bioorg Med Chem Lett 16: 1350-2 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.055
BindingDB Entry DOI: 10.7270/Q2HX1C83
More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50178543
PNG
(2,5-bis(4-methoxyphenyl)thiophene | CHEMBL378797)
Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(OC)cc1
Show InChI InChI=1S/C18H16O2S/c1-19-15-7-3-13(4-8-15)17-11-12-18(21-17)14-5-9-16(20-2)10-6-14/h3-12H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
108n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates


Bioorg Med Chem Lett 16: 1350-2 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.055
BindingDB Entry DOI: 10.7270/Q2HX1C83
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (human))
BDBM25850
PNG
(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C16H12O2S/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,17-18H
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.95E+3n/an/an/an/an/an/a



Saarland University



Assay Description
Tritiated E2 was incubated with 17beta-HSD2, cofactor, and inhibitor. The amount of labeled E1 formed was quantified by HPLC. Detection and quantific...


J Med Chem 51: 6725-39 (2008)


Article DOI: 10.1021/jm8006917
BindingDB Entry DOI: 10.7270/Q2RB72XG
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299627
PNG
(4-[5-(4-Hydroxyphenyl)-2-thienyl]benzene-1,2-diol ...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H12O3S/c17-12-4-1-10(2-5-12)15-7-8-16(20-15)11-3-6-13(18)14(19)9-11/h1-9,17-19H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299626
PNG
(5-[5-(4-Hydroxyphenyl)-2-thienyl]-2-methylphenol |...)
Show SMILES Cc1ccc(cc1O)-c1ccc(s1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H14O2S/c1-11-2-3-13(10-15(11)19)17-9-8-16(20-17)12-4-6-14(18)7-5-12/h2-10,18-19H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (human))
BDBM50299636
PNG
(4-[5-(3-Hydroxyphenyl)-2-thienyl]benzene-1,2-diol ...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H12O3S/c17-12-3-1-2-10(8-12)15-6-7-16(20-15)11-4-5-13(18)14(19)9-11/h1-9,17-19H
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.64E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM25850
PNG
(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C16H12O2S/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,17-18H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (human))
BDBM25850
PNG
(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C16H12O2S/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,17-18H
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.95E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD2 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair
17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1)


(Homo sapiens (Human))
BDBM25850
PNG
(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C16H12O2S/c17-13-6-4-11(5-7-13)15-8-9-16(19-15)12-2-1-3-14(18)10-12/h1-10,17-18H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 69n/an/an/an/a7.037



Saarland University



Assay Description
Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...


J Med Chem 51: 6725-39 (2008)


Article DOI: 10.1021/jm8006917
BindingDB Entry DOI: 10.7270/Q2RB72XG
More data for this
Ligand-Target Pair
17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1)


(Homo sapiens (Human))
BDBM25848
PNG
(4-(5-phenylthiophen-2-yl)phenol | hydroxyphenyl su...)
Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C16H12OS/c17-14-8-6-13(7-9-14)16-11-10-15(18-16)12-4-2-1-3-5-12/h1-11,17H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a7.037



Saarland University



Assay Description
Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...


J Med Chem 51: 6725-39 (2008)


Article DOI: 10.1021/jm8006917
BindingDB Entry DOI: 10.7270/Q2RB72XG
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50299636
PNG
(4-[5-(3-Hydroxyphenyl)-2-thienyl]benzene-1,2-diol ...)
Show SMILES Oc1cccc(c1)-c1ccc(s1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H12O3S/c17-12-3-1-2-10(8-12)15-6-7-16(20-15)11-4-5-13(18)14(19)9-11/h1-9,17-19H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 402n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of human placental 17betaHSD1 by radiodetection assay


J Med Chem 52: 6724-43 (2009)


Article DOI: 10.1021/jm901195w
BindingDB Entry DOI: 10.7270/Q2CR5TDT
More data for this
Ligand-Target Pair