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8 similar compounds to monomer 26673

Compile data set for download or QSAR
Wt: 302.3
BDBM26674
Wt: 304.2
BDBM26676
Wt: 469.6
BDBM50209180
Wt: 288.3
BDBM50209188
Wt: 395.2
BDBM50209192
Wt: 477.7
BDBM50209196
Wt: 395.2
BDBM50209199
Wt: 436.0
BDBM50209209

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 26674,26676,50209180,50209188,50209192,50209196,50209199,50209209   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM26674
PNG
(6-(2-hydroxy-5-methylphenyl)-2-oxo-4-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)17-10-14(13-5-3-2-4-6-13)16(11-20)19(23)21-17/h2-10,22H,1H3,(H,21,23)
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n/an/a 340n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM26676
PNG
(6-(2-hydroxyphenyl)-4-(4-hydroxyphenyl)-2-oxo-1,2-...)
Show SMILES Oc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1O
Show InChI InChI=1S/C18H12N2O3/c19-10-15-14(11-5-7-12(21)8-6-11)9-16(20-18(15)23)13-3-1-2-4-17(13)22/h1-9,21-22H,(H,20,23)
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n/an/a 430n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209192
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,5-dimethylphenyl)...)
Show SMILES Cc1ccc(C)c(c1)-c1cc([nH]c(=O)c1C#N)-c1cc(Br)ccc1O
Show InChI InChI=1S/C20H15BrN2O2/c1-11-3-4-12(2)14(7-11)15-9-18(23-20(25)17(15)10-22)16-8-13(21)5-6-19(16)24/h3-9,24H,1-2H3,(H,23,25)
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n/an/an/a 1.17E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209196
PNG
(6-(5-bromo-2-hydroxy-phenyl)-4-(4-chloro-biphenyl-...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(ccc2Cl)-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C24H14BrClN2O2/c25-16-7-9-23(29)19(11-16)22-12-17(20(13-27)24(30)28-22)18-10-15(6-8-21(18)26)14-4-2-1-3-5-14/h1-12,29H,(H,28,30)
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n/an/an/a>4.30E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50209188
PNG
(6-(2-Hydroxy-phenyl)-2-oxo-4-phenyl-1,2-dihydro-py...)
Show SMILES Oc1ccccc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H12N2O2/c19-11-15-14(12-6-2-1-3-7-12)10-16(20-18(15)22)13-8-4-5-9-17(13)21/h1-10,21H,(H,20,22)
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n/an/a 50n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


J Med Chem 55: 2641-8 (2012)


Article DOI: 10.1021/jm2014698
BindingDB Entry DOI: 10.7270/Q2Q2418B
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209209
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,5-dichlorophenyl)...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H9BrCl2N2O2/c19-9-1-4-17(24)13(5-9)16-7-11(14(8-22)18(25)23-16)12-6-10(20)2-3-15(12)21/h1-7,24H,(H,23,25)
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n/an/an/a 810n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209180
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2-chloro-5-(trifluo...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H9BrClF3N2O2/c20-10-2-4-17(27)13(6-10)16-7-11(14(8-25)18(28)26-16)12-5-9(19(22,23)24)1-3-15(12)21/h1-7,27H,(H,26,28)
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n/an/an/a 490n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209199
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,4-dimethylphenyl)...)
Show SMILES Cc1ccc(c(C)c1)-c1cc([nH]c(=O)c1C#N)-c1cc(Br)ccc1O
Show InChI InChI=1S/C20H15BrN2O2/c1-11-3-5-14(12(2)7-11)15-9-18(23-20(25)17(15)10-22)16-8-13(21)4-6-19(16)24/h3-9,24H,1-2H3,(H,23,25)
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n/an/an/a 700n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209209
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,5-dichlorophenyl)...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H9BrCl2N2O2/c19-9-1-4-17(24)13(5-9)16-7-11(14(8-22)18(25)23-16)12-6-10(20)2-3-15(12)21/h1-7,24H,(H,23,25)
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n/an/an/a 800n/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of survivin


Eur J Med Chem 45: 90-7 (2010)


Article DOI: 10.1016/j.ejmech.2009.09.029
BindingDB Entry DOI: 10.7270/Q20K28N2
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens (Human))
BDBM50209188
PNG
(6-(2-Hydroxy-phenyl)-2-oxo-4-phenyl-1,2-dihydro-py...)
Show SMILES Oc1ccccc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H12N2O2/c19-11-15-14(12-6-2-1-3-7-12)10-16(20-18(15)22)13-8-4-5-9-17(13)21/h1-10,21H,(H,20,22)
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n/an/an/a 7.50E+4n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair