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6 similar compounds to monomer 24036

Compile data set for download or QSAR
Wt: 415.8
BDBM28306
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Wt: 381.4
BDBM50063134
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Wt: 457.5
BDBM50077152
Wt: 405.4
BDBM50077153
Wt: 384.2
BDBM50077156
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Wt: 460.3
BDBM50084284

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 28306,50063134,50077152,50077153,50077156,50084284   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (Human))
BDBM28306
PNG
((2R)-2-{[4-(4-chlorophenyl)benzene]sulfonamido}-3-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m1/s1
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n/an/a 3.20E+3n/an/an/an/a7.537



Japan Tobacco Inc.



Assay Description
The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...


Bioorg Med Chem Lett 19: 1575-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.024
BindingDB Entry DOI: 10.7270/Q2PV6HPW
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063134
PNG
((S)-2-(Biphenyl-4-sulfonylamino)-3-phenyl-propioni...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H19NO4S/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,22H,15H2,(H,23,24)/t20-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077156
PNG
((R)-2-(4-Bromo-benzenesulfonylamino)-3-phenyl-prop...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C15H14BrNO4S/c16-12-6-8-13(9-7-12)22(20,21)17-14(15(18)19)10-11-4-2-1-3-5-11/h1-9,14,17H,10H2,(H,18,19)/t14-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077153
PNG
((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C23H19NO4S/c25-23(26)22(17-20-9-5-2-6-10-20)24-29(27,28)21-15-13-19(14-16-21)12-11-18-7-3-1-4-8-18/h1-10,13-16,22,24H,17H2,(H,25,26)/t22-/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077152
PNG
((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077152
PNG
((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077156
PNG
((R)-2-(4-Bromo-benzenesulfonylamino)-3-phenyl-prop...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C15H14BrNO4S/c16-12-6-8-13(9-7-12)22(20,21)17-14(15(18)19)10-11-4-2-1-3-5-11/h1-9,14,17H,10H2,(H,18,19)/t14-/m1/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 5.60E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-9 (MMP-9)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084284
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-3-phenyl-pro...)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1
Show InChI InChI=1S/C21H18BrNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50077153
PNG
((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C23H19NO4S/c25-23(26)22(17-20-9-5-2-6-10-20)24-29(27,28)21-15-13-19(14-16-21)12-11-18-7-3-1-4-8-18/h1-10,13-16,22,24H,17H2,(H,25,26)/t22-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Shionogi & Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)


J Med Chem 42: 1723-38 (1999)


Article DOI: 10.1021/jm980514x
BindingDB Entry DOI: 10.7270/Q2KP81BQ
More data for this
Ligand-Target Pair