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15 similar compounds to monomer 28394

Compile data set for download or QSAR
Wt: 324.3
BDBM28404
Wt: 323.3
BDBM28405
Wt: 366.4
BDBM28406
Wt: 324.3
BDBM28407
Wt: 310.3
BDBM28408
Wt: 284.3
BDBM28410
Wt: 298.3
BDBM28411
Wt: 326.3
BDBM28412
Wt: 340.4
BDBM28413
Wt: 326.3
BDBM28414
Wt: 299.3
BDBM28415
Wt: 338.4
BDBM28417
Wt: 312.3
BDBM28395
Wt: 352.4
BDBM28399
Wt: 337.4
BDBM28400

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 28404,28405,28406,28407,28408,28410,28411,28412,28413,28414,28415,28417,28395,28399,28400   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM28395
PNG
((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+
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n/an/a 33n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28417
PNG
((2E)-3-(3-{6-[4-(aminomethyl)piperidin-1-yl]pyrazi...)
Show SMILES NCC1CCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c20-11-15-6-8-23(9-7-15)18-13-21-12-17(22-18)16-3-1-2-14(10-16)4-5-19(24)25/h1-5,10,12-13,15H,6-9,11,20H2,(H,24,25)/b5-4+
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28400
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(N)=O)c1
Show InChI InChI=1S/C19H23N5O/c1-23-8-3-9-24(11-10-23)19-14-21-13-17(22-19)16-5-2-4-15(12-16)6-7-18(20)25/h2,4-7,12-14H,3,8-11H2,1H3,(H2,20,25)/b7-6+
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n/an/a 1.20E+3n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28404
PNG
((2E)-3-{3-[6-(1,4-diazepan-1-yl)pyrazin-2-yl]pheny...)
Show SMILES OC(=O)\C=C\c1cccc(c1)-c1cncc(n1)N1CCCNCC1
Show InChI InChI=1S/C18H20N4O2/c23-18(24)6-5-14-3-1-4-15(11-14)16-12-20-13-17(21-16)22-9-2-7-19-8-10-22/h1,3-6,11-13,19H,2,7-10H2,(H,23,24)/b6-5+
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n/an/a 10n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28405
PNG
((2E)-3-{3-[6-(azepan-1-yl)pyrazin-2-yl]phenyl}prop...)
Show SMILES OC(=O)\C=C\c1cccc(c1)-c1cncc(n1)N1CCCCCC1
Show InChI InChI=1S/C19H21N3O2/c23-19(24)9-8-15-6-5-7-16(12-15)17-13-20-14-18(21-17)22-10-3-1-2-4-11-22/h5-9,12-14H,1-4,10-11H2,(H,23,24)/b9-8+
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n/an/a 3.30E+3n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28406
PNG
((2E)-3-{3-[6-(4-acetyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CC(=O)N1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C20H22N4O3/c1-15(25)23-8-3-9-24(11-10-23)19-14-21-13-18(22-19)17-5-2-4-16(12-17)6-7-20(26)27/h2,4-7,12-14H,3,8-11H2,1H3,(H,26,27)/b7-6+
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n/an/a 880n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28407
PNG
((2E)-3-{3-[6-(4-methylpiperazin-1-yl)pyrazin-2-yl]...)
Show SMILES CN1CCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C18H20N4O2/c1-21-7-9-22(10-8-21)17-13-19-12-16(20-17)15-4-2-3-14(11-15)5-6-18(23)24/h2-6,11-13H,7-10H2,1H3,(H,23,24)/b6-5+
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n/an/a 150n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28408
PNG
((2E)-3-{3-[6-(piperazin-1-yl)pyrazin-2-yl]phenyl}p...)
Show SMILES OC(=O)\C=C\c1cccc(c1)-c1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C17H18N4O2/c22-17(23)5-4-13-2-1-3-14(10-13)15-11-19-12-16(20-15)21-8-6-18-7-9-21/h1-5,10-12,18H,6-9H2,(H,22,23)/b5-4+
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n/an/a 200n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28410
PNG
((2E)-3-(3-{6-[(2-aminoethyl)amino]pyrazin-2-yl}phe...)
Show SMILES NCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C15H16N4O2/c16-6-7-18-14-10-17-9-13(19-14)12-3-1-2-11(8-12)4-5-15(20)21/h1-5,8-10H,6-7,16H2,(H,18,19)(H,20,21)/b5-4+
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n/an/a 140n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28411
PNG
((2E)-3-(3-{6-[(3-aminopropyl)amino]pyrazin-2-yl}ph...)
Show SMILES NCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C16H18N4O2/c17-7-2-8-19-15-11-18-10-14(20-15)13-4-1-3-12(9-13)5-6-16(21)22/h1,3-6,9-11H,2,7-8,17H2,(H,19,20)(H,21,22)/b6-5+
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n/an/a 27n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28395
PNG
((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+
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PubMed
n/an/a 22n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28412
PNG
((2E)-3-[3-(6-{[3-(dimethylamino)propyl]amino}pyraz...)
Show SMILES CN(C)CCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C18H22N4O2/c1-22(2)10-4-9-20-17-13-19-12-16(21-17)15-6-3-5-14(11-15)7-8-18(23)24/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,20,21)(H,23,24)/b8-7+
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n/an/a 94n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28413
PNG
((2E)-3-[3-(6-{[3-(dimethylamino)propyl](methyl)ami...)
Show SMILES CN(C)CCCN(C)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H24N4O2/c1-22(2)10-5-11-23(3)18-14-20-13-17(21-18)16-7-4-6-15(12-16)8-9-19(24)25/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,24,25)/b9-8+
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n/an/a 370n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28414
PNG
((2E)-3-(3-{6-[(2-acetamidoethyl)amino]pyrazin-2-yl...)
Show SMILES CC(=O)NCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H18N4O3/c1-12(22)19-7-8-20-16-11-18-10-15(21-16)14-4-2-3-13(9-14)5-6-17(23)24/h2-6,9-11H,7-8H2,1H3,(H,19,22)(H,20,21)(H,23,24)/b6-5+
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PubMed
n/an/a 1.02E+3n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28415
PNG
((2E)-3-(3-{6-[(3-hydroxypropyl)amino]pyrazin-2-yl}...)
Show SMILES OCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C16H17N3O3/c20-8-2-7-18-15-11-17-10-14(19-15)13-4-1-3-12(9-13)5-6-16(21)22/h1,3-6,9-11,20H,2,7-8H2,(H,18,19)(H,21,22)/b6-5+
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n/an/a 310n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM28399
PNG
(methyl (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)py...)
Show SMILES COC(=O)\C=C\c1cccc(c1)-c1cncc(n1)N1CCCN(C)CC1
Show InChI InChI=1S/C20H24N4O2/c1-23-9-4-10-24(12-11-23)19-15-21-14-18(22-19)17-6-3-5-16(13-17)7-8-20(25)26-2/h3,5-8,13-15H,4,9-12H2,1-2H3/b8-7+
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n/an/a>8.00E+3n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair