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61 similar compounds to monomer 134706

Compile data set for download or QSAR
Wt: 492.4
BDBM134609
Wt: 400.4
BDBM134655
Wt: 498.4
BDBM134750
Wt: 415.4
BDBM29795
Wt: 405.8
BDBM134845
Wt: 397.4
BDBM134860
Wt: 385.4
BDBM134862
Wt: 429.4
BDBM134863
Wt: 497.4
BDBM134763
Wt: 429.4
BDBM134612
Wt: 513.4
BDBM134773
Wt: 513.4
BDBM134775
Wt: 482.4
BDBM134781
Wt: 482.4
BDBM134782
Wt: 467.4
BDBM134603
Displayed 1 to 15 (of 61 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 134609,134655,134750,29795,134845,134860,134862,134863,134763,134612,134773,134775,134781,134782,134603   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM29795
PNG
(US8846698, 333)
Show SMILES COCc1ccc(CC(=O)Nc2cncc(c2)C(=O)c2cn(C)c3ncncc23)cc1
Show InChI InChI=1S/C23H21N5O3/c1-28-12-20(19-11-25-14-26-23(19)28)22(30)17-8-18(10-24-9-17)27-21(29)7-15-3-5-16(6-4-15)13-31-2/h3-6,8-12,14H,7,13H2,1-2H3,(H,27,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.80E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134863
PNG
(US8846698, 339)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)C(CO)c3ccccc3)c2)c2cncnc12
Show InChI InChI=1/C24H23N5O3/c1-15(2)29-12-20(19-11-26-14-27-23(19)29)22(31)17-8-18(10-25-9-17)28-24(32)21(13-30)16-6-4-3-5-7-16/h3-12,14-15,21,30H,13H2,1-2H3,(H,28,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 251n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134781
PNG
(US8846698, 244)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H21F3N6O2/c1-13(2)33-12-19(18-11-30-23(28)32-22(18)33)21(35)15-8-17(10-29-9-15)31-20(34)7-14-3-5-16(6-4-14)24(25,26)27/h3-6,8-13H,7H2,1-2H3,(H,31,34)(H2,28,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.69n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134782
PNG
(US8846698, 245)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H21F3N6O2/c1-13(2)33-12-19(18-11-30-23(28)32-22(18)33)21(35)15-8-17(10-29-9-15)31-20(34)7-14-4-3-5-16(6-14)24(25,26)27/h3-6,8-13H,7H2,1-2H3,(H,31,34)(H2,28,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.70n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134845
PNG
(US8846698, 319)
Show SMILES Cn1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncnc12
Show InChI InChI=1S/C21H16ClN5O2/c1-27-11-18(17-10-24-12-25-21(17)27)20(29)14-7-16(9-23-8-14)26-19(28)6-13-2-4-15(22)5-3-13/h2-5,7-12H,6H2,1H3,(H,26,28)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 188n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134603
PNG
(US8846698, 66)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C24H20F3N5O2/c1-14(2)32-12-20(19-11-29-13-30-23(19)32)22(34)16-8-18(10-28-9-16)31-21(33)7-15-4-3-5-17(6-15)24(25,26)27/h3-6,8-14H,7H2,1-2H3,(H,31,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.55n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134609
PNG
(US8846698, 72)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(C#N)c(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H19F3N6O2/c1-14(2)34-12-20(19-11-31-13-32-24(19)34)23(36)17-7-18(10-30-9-17)33-22(35)6-15-3-4-16(8-29)21(5-15)25(26,27)28/h3-5,7,9-14H,6H2,1-2H3,(H,33,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 63.3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134612
PNG
(US8846698, 75)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(CO)c3)c2)c2cncnc12
Show InChI InChI=1S/C24H23N5O3/c1-15(2)29-12-21(20-11-26-14-27-24(20)29)23(32)18-8-19(10-25-9-18)28-22(31)7-16-4-3-5-17(6-16)13-30/h3-6,8-12,14-15,30H,7,13H2,1-2H3,(H,28,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 567n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134750
PNG
(US8846698, 213 | US8846698, 215)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1/C24H21F3N6O3/c1-13(12-34)33-11-19(18-10-30-23(28)32-22(18)33)21(36)15-7-17(9-29-8-15)31-20(35)6-14-3-2-4-16(5-14)24(25,26)27/h2-5,7-11,13,34H,6,12H2,1H3,(H,31,35)(H2,28,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.03n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134750
PNG
(US8846698, 213 | US8846698, 215)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1/C24H21F3N6O3/c1-13(12-34)33-11-19(18-10-30-23(28)32-22(18)33)21(36)15-7-17(9-29-8-15)31-20(35)6-14-3-2-4-16(5-14)24(25,26)27/h2-5,7-11,13,34H,6,12H2,1H3,(H,31,35)(H2,28,30,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134763
PNG
(US8846698, 226)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H22F3N5O3/c1-24(2,13-34)33-12-20(19-11-30-14-31-23(19)33)22(36)16-8-18(10-29-9-16)32-21(35)7-15-4-3-5-17(6-15)25(26,27)28/h3-6,8-12,14,34H,7,13H2,1-2H3,(H,32,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.61n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134773
PNG
(US8846698, 236)
Show SMILES CC(CO)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H22F3N5O4/c1-24(12-34,13-35)33-11-20(19-10-30-14-31-23(19)33)22(37)16-7-18(9-29-8-16)32-21(36)6-15-2-4-17(5-3-15)25(26,27)28/h2-5,7-11,14,34-35H,6,12-13H2,1H3,(H,32,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25.2n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134775
PNG
(US8846698, 238)
Show SMILES CC(CO)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H22F3N5O4/c1-24(12-34,13-35)33-11-20(19-10-30-14-31-23(19)33)22(37)16-7-18(9-29-8-16)32-21(36)6-15-3-2-4-17(5-15)25(26,27)28/h2-5,7-11,14,34-35H,6,12-13H2,1H3,(H,32,36)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.36n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134860
PNG
(US8846698, 336)
Show SMILES Cn1cc(C(=O)c2cncc(NC(=O)C3(CC3)c3ccccc3)c2)c2cncnc12
Show InChI InChI=1S/C23H19N5O2/c1-28-13-19(18-12-25-14-26-21(18)28)20(29)15-9-17(11-24-10-15)27-22(30)23(7-8-23)16-5-3-2-4-6-16/h2-6,9-14H,7-8H2,1H3,(H,27,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.80E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134862
PNG
(US8846698, 338)
Show SMILES C[C@@H](C(=O)Nc1cncc(c1)C(=O)c1cn(C)c2ncncc12)c1ccccc1
Show InChI InChI=1S/C22H19N5O2/c1-14(15-6-4-3-5-7-15)22(29)26-17-8-16(9-23-10-17)20(28)19-12-27(2)21-18(19)11-24-13-25-21/h3-14H,1-2H3,(H,26,29)/t14-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

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US Patent
n/an/a 2.73E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM134655
PNG
(US8846698, 118)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3cccnc3)c2)c2cncnc12
Show InChI InChI=1S/C22H20N6O2/c1-14(2)28-12-19(18-11-25-13-26-22(18)28)21(30)16-7-17(10-24-9-16)27-20(29)6-15-4-3-5-23-8-15/h3-5,7-14H,6H2,1-2H3,(H,27,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.55E+3n/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair