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13 similar compounds to monomer 50361859

Compile data set for download or QSAR
Wt: 320.3
BDBM30298
Wt: 349.3
BDBM30300
Wt: 334.3
BDBM30301
Wt: 334.3
BDBM50361835
Wt: 334.3
BDBM50361836
Wt: 370.4
BDBM50361847
Wt: 349.3
BDBM50361852
Wt: 348.3
BDBM50361853
Wt: 348.3
BDBM50361854
Wt: 348.3
BDBM50361855
Wt: 346.3
BDBM50361857
Wt: 360.4
BDBM50361858
Wt: 334.3
BDBM50361860

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 30298,30300,30301,50361835,50361836,50361847,50361852,50361853,50361854,50361855,50361857,50361858,50361860   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (Human))
BDBM30298
PNG
(indole-based 7-membered lactam, 23a)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C18H16N4O2/c23-17(21-14-3-1-6-19-11-14)13-5-4-12-9-16-18(24)20-7-2-8-22(16)15(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,20,24)(H,21,23)
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n/an/a 270n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361847
PNG
(CHEMBL1938798 | US9150577, 190)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)
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n/an/a 34n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (Human))
BDBM30301
PNG
(indole-based 7-membered lactam, 25d)
Show SMILES CC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-9-21-19(25)17-7-13-4-5-14(8-16(13)23(17)11-12)18(24)22-15-3-2-6-20-10-15/h2-8,10,12H,9,11H2,1H3,(H,21,25)(H,22,24)
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n/an/a 320n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361855
PNG
(CHEMBL1938768 | US9150577, 9)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C20H20N4O2/c1-20(2)11-22-19(26)17-8-13-5-6-14(9-16(13)24(17)12-20)18(25)23-15-4-3-7-21-10-15/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,25)
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n/an/a 4.60E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361835
PNG
(CHEMBL1938765 | US9150577, 10)
Show SMILES CC1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-6-8-21-19(25)17-9-13-4-5-14(10-16(13)23(12)17)18(24)22-15-3-2-7-20-11-15/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24)
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n/an/a 41n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361857
PNG
(CHEMBL1938770 | US9150577, 123)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CC4)Cn3c2c1
Show InChI InChI=1S/C20H18N4O2/c25-18(23-15-2-1-7-21-10-15)14-4-3-13-8-17-19(26)22-11-20(5-6-20)12-24(17)16(13)9-14/h1-4,7-10H,5-6,11-12H2,(H,22,26)(H,23,25)
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n/an/a 430n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361854
PNG
(CHEMBL1938767 | US9150577, 151)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(cc3n2[C@H]1C)C(=O)Nc1cccnc1
Show InChI InChI=1/C20H20N4O2/c1-12-10-22-20(26)18-8-14-5-6-15(9-17(14)24(18)13(12)2)19(25)23-16-4-3-7-21-11-16/h3-9,11-13H,10H2,1-2H3,(H,22,26)(H,23,25)/t12-,13+/s2
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n/an/a 1.10E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361858
PNG
(CHEMBL1938771 | US9150577, 153)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CCC4)Cn3c2c1
Show InChI InChI=1S/C21H20N4O2/c26-19(24-16-3-1-8-22-11-16)15-5-4-14-9-18-20(27)23-12-21(6-2-7-21)13-25(18)17(14)10-15/h1,3-5,8-11H,2,6-7,12-13H2,(H,23,27)(H,24,26)
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n/an/a 3.30E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM50361847
PNG
(CHEMBL1938798 | US9150577, 190)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)
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n/an/a 34n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM30298
PNG
(indole-based 7-membered lactam, 23a)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C18H16N4O2/c23-17(21-14-3-1-6-19-11-14)13-5-4-12-9-16-18(24)20-7-2-8-22(16)15(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,20,24)(H,21,23)
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n/an/a 1.94E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361835
PNG
(CHEMBL1938765 | US9150577, 10)
Show SMILES CC1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-6-8-21-19(25)17-9-13-4-5-14(10-16(13)23(12)17)18(24)22-15-3-2-7-20-11-15/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24)
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n/an/a 890n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361836
PNG
(CHEMBL272096)
Show SMILES CC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-9-21-19(25)17-7-13-4-5-14(8-16(13)23(17)11-12)18(24)22-15-3-2-6-20-10-15/h2-8,10,12H,9,11H2,1H3,(H,21,25)(H,22,24)
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n/an/a 4.89E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361847
PNG
(CHEMBL1938798 | US9150577, 190)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C22H18N4O2/c27-21(25-17-10-14-4-1-2-5-18(14)24-13-17)16-7-6-15-11-20-22(28)23-8-3-9-26(20)19(15)12-16/h1-2,4-7,10-13H,3,8-9H2,(H,23,28)(H,25,27)
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n/an/a 340n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM30298
PNG
(indole-based 7-membered lactam, 23a)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2c1
Show InChI InChI=1S/C18H16N4O2/c23-17(21-14-3-1-6-19-11-14)13-5-4-12-9-16-18(24)20-7-2-8-22(16)15(12)10-13/h1,3-6,9-11H,2,7-8H2,(H,20,24)(H,21,23)
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n/an/a 240n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361835
PNG
(CHEMBL1938765 | US9150577, 10)
Show SMILES CC1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-6-8-21-19(25)17-9-13-4-5-14(10-16(13)23(12)17)18(24)22-15-3-2-7-20-11-15/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24)
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n/an/a 41n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361836
PNG
(CHEMBL272096)
Show SMILES CC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H18N4O2/c1-12-9-21-19(25)17-7-13-4-5-14(8-16(13)23(17)11-12)18(24)22-15-3-2-6-20-10-15/h2-8,10,12H,9,11H2,1H3,(H,21,25)(H,22,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361852
PNG
(CHEMBL272309)
Show SMILES NCC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H19N5O2/c20-8-12-9-22-19(26)17-6-13-3-4-14(7-16(13)24(17)11-12)18(25)23-15-2-1-5-21-10-15/h1-7,10,12H,8-9,11,20H2,(H,22,26)(H,23,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361853
PNG
(CHEMBL1938766)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(cc3n2[C@@H]1C)C(=O)Nc1cccnc1
Show InChI InChI=1/C20H20N4O2/c1-12-10-22-20(26)18-8-14-5-6-15(9-17(14)24(18)13(12)2)19(25)23-16-4-3-7-21-11-16/h3-9,11-13H,10H2,1-2H3,(H,22,26)(H,23,25)/t12-,13-/s2
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n/an/a 240n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361854
PNG
(CHEMBL1938767 | US9150577, 151)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(cc3n2[C@H]1C)C(=O)Nc1cccnc1
Show InChI InChI=1/C20H20N4O2/c1-12-10-22-20(26)18-8-14-5-6-15(9-17(14)24(18)13(12)2)19(25)23-16-4-3-7-21-11-16/h3-9,11-13H,10H2,1-2H3,(H,22,26)(H,23,25)/t12-,13+/s2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361855
PNG
(CHEMBL1938768 | US9150577, 9)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C20H20N4O2/c1-20(2)11-22-19(26)17-8-13-5-6-14(9-16(13)24(17)12-20)18(25)23-15-4-3-7-21-10-15/h3-10H,11-12H2,1-2H3,(H,22,26)(H,23,25)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361857
PNG
(CHEMBL1938770 | US9150577, 123)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CC4)Cn3c2c1
Show InChI InChI=1S/C20H18N4O2/c25-18(23-15-2-1-7-21-10-15)14-4-3-13-8-17-19(26)22-11-20(5-6-20)12-24(17)16(13)9-14/h1-4,7-10H,5-6,11-12H2,(H,22,26)(H,23,25)
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n/an/a 410n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361858
PNG
(CHEMBL1938771 | US9150577, 153)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCC4(CCC4)Cn3c2c1
Show InChI InChI=1S/C21H20N4O2/c26-19(24-16-3-1-8-22-11-16)15-5-4-14-9-18-20(27)23-12-21(6-2-7-21)13-25(18)17(14)10-15/h1,3-5,8-11H,2,6-7,12-13H2,(H,23,27)(H,24,26)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50361860
PNG
(CHEMBL1938773)
Show SMILES CC1CCn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1/C19H18N4O2/c1-12-6-8-23-16-10-14(18(24)22-15-3-2-7-20-11-15)5-4-13(16)9-17(23)19(25)21-12/h2-5,7,9-12H,6,8H2,1H3,(H,21,25)(H,22,24)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Boehringer-Ingelheim Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of RSK2 phosphorylation by luminescence assay


Bioorg Med Chem Lett 22: 733-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.030
BindingDB Entry DOI: 10.7270/Q2XW4K7N
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (Human))
BDBM30300
PNG
(indole-based 7-membered lactam, 25a)
Show SMILES NCC1CNC(=O)c2cc3ccc(cc3n2C1)C(=O)Nc1cccnc1
Show InChI InChI=1/C19H19N5O2/c20-8-12-9-22-19(26)17-6-13-3-4-14(7-16(13)24(17)11-12)18(25)23-15-2-1-5-21-10-15/h1-7,10,12H,8-9,11,20H2,(H,22,26)(H,23,25)
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n/an/a 29n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair