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3 similar compounds to monomer 31175

Compile data set for download or QSAR
Wt: 176.2
BDBM31190
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Wt: 190.2
BDBM31191
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Wt: 252.3
BDBM49948
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 31190,31191,49948   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31190
PNG
(thiazol-2-amine, 1)
Show SMILES Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)
PDB
MMDB

NCI pathway
KEGG

B.MOAD
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UniChem

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Article
PubMed
n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens (Human))
BDBM31191
PNG
(thiazol-2-amine, 2)
Show SMILES Cc1ccc(cc1)-c1csc(N)n1
Show InChI InChI=1S/C10H10N2S/c1-7-2-4-8(5-3-7)9-6-13-10(11)12-9/h2-6H,1H3,(H2,11,12)
PDB
MMDB

NCI pathway
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B.MOAD
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/an/an/an/a7.523



University of Virginia at Charlottesville



Assay Description
For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c...


Chem Biol 14: 1186-97 (2007)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2862DTN
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (Human))
BDBM31190
PNG
(thiazol-2-amine, 1)
Show SMILES Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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DrugBank
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PC sid
UniChem

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Article
PubMed
n/an/a 1.00E+6n/an/an/an/an/an/a



Institute for Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AI


J Med Chem 53: 1172-89 (2010)


Article DOI: 10.1021/jm9014718
BindingDB Entry DOI: 10.7270/Q2BC40G9
More data for this
Ligand-Target Pair
tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]


(Homo sapiens (Human))
BDBM49948
PNG
(4-(4-phenylphenyl)-1,3-thiazol-2-amine | 4-(4-phen...)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2S/c16-15-17-14(10-18-15)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10H,(H2,16,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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PCBioAssay
n/an/an/an/a>1.25E+4n/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2P55M4P
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM31190
PNG
(thiazol-2-amine, 1)
Show SMILES Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.39E+6n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Bioorg Med Chem 17: 3916-22 (2009)


Article DOI: 10.1016/j.bmc.2009.04.030
BindingDB Entry DOI: 10.7270/Q25T3KGW
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM49948
PNG
(4-(4-phenylphenyl)-1,3-thiazol-2-amine | 4-(4-phen...)
Show SMILES Nc1nc(cs1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2S/c16-15-17-14(10-18-15)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10H,(H2,16,17)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

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PCBioAssay
n/an/an/an/a 2.42E+3n/an/an/an/a



SRMLSC

Curated by PubChem BioAssay


Assay Description
Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27P8WT7
More data for this
Ligand-Target Pair