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3 similar compounds to monomer 50290838

Compile data set for download or QSAR
Wt: 301.1
BDBM3268
Wt: 342.3
BDBM50290837
Wt: 372.3
BDBM50291100

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3268,50290837,50291100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3268
PNG
(4-(3-bromophenoxy)quinazoline | 4-Anilino quinazol...)
Show SMILES Brc1cccc(Oc2ncnc3ccccc23)c1
Show InChI InChI=1S/C14H9BrN2O/c15-10-4-3-5-11(8-10)18-14-12-6-1-2-7-13(12)16-9-17-14/h1-9H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 756n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50291100
PNG
(6,7-Dimethoxy-4-(3,4,5-trimethoxy-phenoxy)-quinazo...)
Show SMILES COc1cc2ncnc(Oc3cc(OC)c(OC)c(OC)c3)c2cc1OC
Show InChI InChI=1S/C19H20N2O6/c1-22-14-8-12-13(9-15(14)23-2)20-10-21-19(12)27-11-6-16(24-3)18(26-5)17(7-11)25-4/h6-10H,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.


Bioorg Med Chem Lett 7: 417-420 (1997)


Article DOI: 10.1016/S0960-894X(97)00034-6
BindingDB Entry DOI: 10.7270/Q2J966VN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290837
PNG
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazolin...)
Show SMILES COc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C18H18N2O5/c1-21-14-6-5-11(7-15(14)22-2)25-18-12-8-16(23-3)17(24-4)9-13(12)19-10-20-18/h5-10H,1-4H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290837
PNG
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazolin...)
Show SMILES COc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C18H18N2O5/c1-21-14-6-5-11(7-15(14)22-2)25-18-12-8-16(23-3)17(24-4)9-13(12)19-10-20-18/h5-10H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 570n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Bioorg Med Chem Lett 7: 2935-2940 (1997)


Article DOI: 10.1016/S0960-894X(97)10117-2
BindingDB Entry DOI: 10.7270/Q20Z738R
More data for this
Ligand-Target Pair