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24 similar compounds to monomer 50219156

Compile data set for download or QSAR
Wt: 265.3
BDBM3286
Wt: 281.3
BDBM3287
Wt: 281.3
BDBM3288
Wt: 295.3
BDBM3289
Purchase
Wt: 325.3
BDBM33205
Purchase
Wt: 369.3
BDBM50038978
Wt: 326.3
BDBM50042774
Wt: 355.3
BDBM50042775
Wt: 415.4
BDBM50042776
Wt: 325.3
BDBM50042777
Wt: 370.3
BDBM50042778
Wt: 355.3
BDBM50042780
Wt: 353.4
BDBM50042782
Wt: 365.4
BDBM50042786
Wt: 415.4
BDBM50042788
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 3286,3287,3288,3289,33205,50038978,50042774,50042775,50042776,50042777,50042778,50042780,50042782,50042786,50042788   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3286
PNG
(4-(Benzylamino)quinazoline deriv. 37 | N-benzyl-8-...)
Show SMILES COc1cccc2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C16H15N3O/c1-20-14-9-5-8-13-15(14)18-11-19-16(13)17-10-12-6-3-2-4-7-12/h2-9,11H,10H2,1H3,(H,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3288
PNG
(4-(Benzylamino)quinazoline deriv. 39 | 4-(benzylam...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1O
Show InChI InChI=1S/C16H15N3O2/c1-21-15-8-13-12(7-14(15)20)16(19-10-18-13)17-9-11-5-3-2-4-6-11/h2-8,10,20H,9H2,1H3,(H,17,18,19)
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n/an/a 56n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3289
PNG
(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H17N3O2/c1-21-15-8-13-14(9-16(15)22-2)19-11-20-17(13)18-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM33205
PNG
(N-(3-methoxybenzyl)quinazolin-4-amine, 4)
Show SMILES COc1cccc(CNc2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C18H19N3O3/c1-22-13-6-4-5-12(7-13)10-19-18-14-8-16(23-2)17(24-3)9-15(14)20-11-21-18/h4-9,11H,10H2,1-3H3,(H,19,20,21)
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n/an/an/an/an/an/an/a7.523



The Institute of Cancer Research



Assay Description
AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...


J Med Chem 52: 4810-9 (2009)


Article DOI: 10.1021/jm900314j
BindingDB Entry DOI: 10.7270/Q27W69KC
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042776
PNG
((3,4,5-Trimethoxy-benzyl)-(6,7,8-trimethoxy-quinaz...)
Show SMILES COc1cc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc(OC)c1OC
Show InChI InChI=1S/C21H25N3O6/c1-25-14-7-12(8-15(26-2)18(14)28-4)10-22-21-13-9-16(27-3)19(29-5)20(30-6)17(13)23-11-24-21/h7-9,11H,10H2,1-6H3,(H,22,23,24)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042777
PNG
(Benzyl-(6,7,8-trimethoxy-quinazolin-4-yl)-amine | ...)
Show SMILES COc1cc2c(NCc3ccccc3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H19N3O3/c1-22-14-9-13-15(17(24-3)16(14)23-2)20-11-21-18(13)19-10-12-7-5-4-6-8-12/h4-9,11H,10H2,1-3H3,(H,19,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042775
PNG
((3-Methoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-...)
Show SMILES COc1cccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H21N3O4/c1-23-13-7-5-6-12(8-13)10-20-19-14-9-15(24-2)17(25-3)18(26-4)16(14)21-11-22-19/h5-9,11H,10H2,1-4H3,(H,20,21,22)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042786
PNG
(CHEMBL125992 | Indan-5-ylmethyl-(6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(NCc3ccc4CCCc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C21H23N3O3/c1-25-17-10-16-18(20(27-3)19(17)26-2)23-12-24-21(16)22-11-13-7-8-14-5-4-6-15(14)9-13/h7-10,12H,4-6,11H2,1-3H3,(H,22,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042788
PNG
((2,4,6-Trimethoxy-benzyl)-(6,7,8-trimethoxy-quinaz...)
Show SMILES COc1cc(OC)c(CNc2ncnc3c(OC)c(OC)c(OC)cc23)c(OC)c1
Show InChI InChI=1S/C21H25N3O6/c1-25-12-7-15(26-2)14(16(8-12)27-3)10-22-21-13-9-17(28-4)19(29-5)20(30-6)18(13)23-11-24-21/h7-9,11H,10H2,1-6H3,(H,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042774
PNG
(CHEMBL341475 | Pyridin-4-ylmethyl-(6,7,8-trimethox...)
Show SMILES COc1cc2c(NCc3ccncc3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C17H18N4O3/c1-22-13-8-12-14(16(24-3)15(13)23-2)20-10-21-17(12)19-9-11-4-6-18-7-5-11/h4-8,10H,9H2,1-3H3,(H,19,20,21)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042780
PNG
((4-Methoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-...)
Show SMILES COc1ccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C19H21N3O4/c1-23-13-7-5-12(6-8-13)10-20-19-14-9-15(24-2)17(25-3)18(26-4)16(14)21-11-22-19/h5-9,11H,10H2,1-4H3,(H,20,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042778
PNG
((4-Nitro-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl...)
Show SMILES COc1cc2c(NCc3ccc(cc3)[N+]([O-])=O)ncnc2c(OC)c1OC
Show InChI InChI=1S/C18H18N4O5/c1-25-14-8-13-15(17(27-3)16(14)26-2)20-10-21-18(13)19-9-11-4-6-12(7-5-11)22(23)24/h4-8,10H,9H2,1-3H3,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50042782
PNG
((4-Ethyl-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl...)
Show SMILES CCc1ccc(CNc2ncnc3c(OC)c(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C20H23N3O3/c1-5-13-6-8-14(9-7-13)11-21-20-15-10-16(24-2)18(25-3)19(26-4)17(15)22-12-23-20/h6-10,12H,5,11H2,1-4H3,(H,21,22,23)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM3289
PNG
(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H17N3O2/c1-21-15-8-13-14(9-16(15)22-2)19-11-20-17(13)18-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,18,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.


Bioorg Med Chem Lett 7: 417-420 (1997)


Article DOI: 10.1016/S0960-894X(97)00034-6
BindingDB Entry DOI: 10.7270/Q2J966VN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3289
PNG
(4-(Benzylamino)quinazoline deriv. 40 | CHEMBL54554...)
Show SMILES COc1cc2ncnc(NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H17N3O2/c1-21-15-8-13-14(9-16(15)22-2)19-11-20-17(13)18-10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,18,19,20)
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor autophosphorylation.


Bioorg Med Chem Lett 7: 417-420 (1997)


Article DOI: 10.1016/S0960-894X(97)00034-6
BindingDB Entry DOI: 10.7270/Q2J966VN
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Eisai Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries


J Med Chem 36: 3765-70 (1994)


Article DOI: 10.1021/jm00076a003
BindingDB Entry DOI: 10.7270/Q279459H
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3287
PNG
(4-(Benzylamino)quinazoline deriv. 38 | 4-(benzylam...)
Show SMILES COc1cc2c(NCc3ccccc3)ncnc2cc1O
Show InChI InChI=1S/C16H15N3O2/c1-21-15-7-12-13(8-14(15)20)18-10-19-16(12)17-9-11-5-3-2-4-6-11/h2-8,10,20H,9H2,1H3,(H,17,18,19)
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n/an/a 588n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair