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9 similar compounds to monomer 34154

Wt: 436.9
BDBM34153
Wt: 434.9
BDBM34156
Wt: 463.0
BDBM34158
Wt: 365.8
BDBM34159
Wt: 365.8
BDBM34160
Wt: 393.9
BDBM34161
Wt: 409.9
BDBM34162
Wt: 463.0
BDBM50266617
Wt: 463.0
BDBM50266618

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 34153,34156,34158,34159,34160,34161,34162,50266617,50266618   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34156
PNG
(indenylsulfonamide, 28)
Show SMILES CN1CCC(C1)C1=CCc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H19ClN4O2S2/c1-23-7-6-13(11-23)15-5-3-12-2-4-14(10-16(12)15)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h2,4-5,8-10,13,22H,3,6-7,11H2,1H3
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Article
PubMed
3 -12.1 1.60E+3n/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34156
PNG
(indenylsulfonamide, 28)
Show SMILES CN1CCC(C1)C1=CCc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H19ClN4O2S2/c1-23-7-6-13(11-23)15-5-3-12-2-4-14(10-16(12)15)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h2,4-5,8-10,13,22H,3,6-7,11H2,1H3
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PubMed
3n/an/an/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting


J Med Chem 52: 6153-7 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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PubMed
4.5 -11.8n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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4.5n/an/an/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50266617
PNG
(6-Chloro-N-[2-methyl-3-(2-pyrrolidin-1-ylethyl)-1H...)
Show SMILES CC1=C(CCN2CCCC2)c2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1
Show InChI InChI=1S/C21H23ClN4O2S2/c1-14-12-15-4-5-16(13-18(15)17(14)6-9-25-7-2-3-8-25)24-30(27,28)20-19(22)23-21-26(20)10-11-29-21/h4-5,10-11,13,24H,2-3,6-9,12H2,1H3
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17n/an/an/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34158
PNG
(indenylsulfonamide, 30)
Show SMILES CN1CCCC(C1)C1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C21H23ClN4O2S2/c1-13-10-14-5-6-16(11-17(14)18(13)15-4-3-7-25(2)12-15)24-30(27,28)20-19(22)23-21-26(20)8-9-29-21/h5-6,8-9,11,15,24H,3-4,7,10,12H2,1-2H3
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PubMed
18 -11.0n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50266618
PNG
(6-Chloro-N-[3-(2-piperidin-1-ylethyl)-1H-inden-5-y...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)Nc1ccc2CC=C(CCN3CCCCC3)c2c1
Show InChI InChI=1S/C21H23ClN4O2S2/c22-19-20(26-12-13-29-21(26)23-19)30(27,28)24-17-7-6-15-4-5-16(18(15)14-17)8-11-25-9-2-1-3-10-25/h5-7,12-14,24H,1-4,8-11H2
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31n/an/an/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34159
PNG
(indenylsulfonamide, 47+48 | isomeric mixture (70% ...)
Show SMILES CC1=Cc2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1
Show InChI InChI=1S/C15H12ClN3O2S2/c1-9-6-10-2-3-12(8-11(10)7-9)18-23(20,21)14-13(16)17-15-19(14)4-5-22-15/h2-5,7-8,18H,6H2,1H3
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PubMed
43 -10.4 3.00E+3n/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34162
PNG
(indenylsulfonamide, 52)
Show SMILES COc1cc2CC(C)=C(C)c2cc1NS(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C17H16ClN3O3S2/c1-9-6-11-7-14(24-3)13(8-12(11)10(9)2)20-26(22,23)16-15(18)19-17-21(16)4-5-25-17/h4-5,7-8,20H,6H2,1-3H3
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PubMed
64 -10.2n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34161
PNG
(indenylsulfonamide, 51)
Show SMILES CC1=CC(C)(C)c2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C17H16ClN3O2S2/c1-10-9-17(2,3)13-5-4-11(8-12(10)13)20-25(22,23)15-14(18)19-16-21(15)6-7-24-16/h4-9,20H,1-3H3
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PubMed
80 -10.1 2.40E+3n/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of human 5HT1A receptor


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
PDB

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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of human SERT


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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Article
PubMed
n/an/an/an/a 0.900n/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34156
PNG
(indenylsulfonamide, 28)
Show SMILES CN1CCC(C1)C1=CCc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H19ClN4O2S2/c1-23-7-6-13(11-23)15-5-3-12-2-4-14(10-16(12)15)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h2,4-5,8-10,13,22H,3,6-7,11H2,1H3
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Article
PubMed
n/an/a 1.58E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5HT-stimulated cAMP production after 30 mins by HTRF ...


J Med Chem 52: 6153-7 (2009)

More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of human adrenergic alpha2A receptor


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34160
PNG
(indenylsulfonamide, 49+50 | isomeric mixture (70% ...)
Show SMILES CC1=Cc2cccc(NS(=O)(=O)c3c(Cl)nc4sccn34)c2C1
Show InChI InChI=1S/C15H12ClN3O2S2/c1-9-7-10-3-2-4-12(11(10)8-9)18-23(20,21)14-13(16)17-15-19(14)5-6-22-15/h2-7,18H,8H2,1H3
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PubMed
n/an/an/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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PubMed
n/an/a 1.13E+3n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of human 5HT2C receptor


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair