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4 similar compounds to monomer 35091

Wt: 471.4
BDBM35090
Wt: 409.4
BDBM35094
Wt: 437.4
BDBM35095
Wt: 409.4
BDBM35096

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 35090,35094,35095,35096   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver X Receptor beta (LXR-beta)


(Homo sapiens (human))
BDBM35090
PNG
(biarylether alcohol quinoline, 5c)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)c1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-14-6-13-24-27(25(17-33-28(24)26)20-8-2-1-3-9-20)21-10-5-12-23(16-21)35-22-11-4-7-19(15-22)18-34/h1-17,34H,18H2
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Article
PubMed
n/an/a 14n/a 210n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (human))
BDBM35094
PNG
(biarylether alcohol quinoline, 5f)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2cccc(CO)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(9-4-10-21(23)24(25,26)27)22(15)17-6-3-8-19(12-17)30-18-7-2-5-16(11-18)14-29/h2-13,29H,14H2,1H3
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Article
PubMed
n/an/a 2.10n/a 233n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (human))
BDBM35095
PNG
(3-methyl quinoline, 8c)
Show SMILES COC(=O)c1ccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(7-4-8-21(23)25(26,27)28)22(15)17-5-3-6-19(13-17)32-18-11-9-16(10-12-18)24(30)31-2/h3-14H,1-2H3
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (human))
BDBM35096
PNG
(biarylether alcohol quinoline, 5g)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2ccc(CO)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(6-3-7-21(23)24(25,26)27)22(15)17-4-2-5-19(12-17)30-18-10-8-16(14-29)9-11-18/h2-13,29H,14H2,1H3
PDB
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Article
PubMed
n/an/a 31n/a 1.37E+3n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Citation and Details
More data for this
Ligand-Target Pair
Liver X receptor beta (LXRB)


(Homo sapiens (Human))
BDBM35094
PNG
(biarylether alcohol quinoline, 5f)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2cccc(CO)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(9-4-10-21(23)24(25,26)27)22(15)17-6-3-8-19(12-17)30-18-7-2-5-16(11-18)14-29/h2-13,29H,14H2,1H3
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PubMed
n/an/a 12n/an/an/an/an/an/a



Wyeth Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (human))
BDBM35094
PNG
(biarylether alcohol quinoline, 5f)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2cccc(CO)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(9-4-10-21(23)24(25,26)27)22(15)17-6-3-8-19(12-17)30-18-7-2-5-16(11-18)14-29/h2-13,29H,14H2,1H3
PDB
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Article
PubMed
n/an/a 10.2n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (human))
BDBM35095
PNG
(3-methyl quinoline, 8c)
Show SMILES COC(=O)c1ccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(7-4-8-21(23)25(26,27)28)22(15)17-5-3-6-19(13-17)32-18-11-9-16(10-12-18)24(30)31-2/h3-14H,1-2H3
PDB
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (human))
BDBM35096
PNG
(biarylether alcohol quinoline, 5g)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2ccc(CO)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(6-3-7-21(23)24(25,26)27)22(15)17-4-2-5-19(12-17)30-18-10-8-16(14-29)9-11-18/h2-13,29H,14H2,1H3
PDB
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Article
PubMed
n/an/a 131n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Citation and Details
More data for this
Ligand-Target Pair
LXR-alpha


(Homo sapiens (human))
BDBM35094
PNG
(biarylether alcohol quinoline, 5f)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2cccc(CO)c2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(9-4-10-21(23)24(25,26)27)22(15)17-6-3-8-19(12-17)30-18-7-2-5-16(11-18)14-29/h2-13,29H,14H2,1H3
PDB
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Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Wyeth Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD


Citation and Details
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (human))
BDBM35090
PNG
(biarylether alcohol quinoline, 5c)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)c1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-14-6-13-24-27(25(17-33-28(24)26)20-8-2-1-3-9-20)21-10-5-12-23(16-21)35-22-11-4-7-19(15-22)18-34/h1-17,34H,18H2
PDB
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Article
PubMed
n/an/a 47n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Citation and Details
More data for this
Ligand-Target Pair