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24 similar compounds to monomer 50052954

Compile data set for download or QSAR
Wt: 427.5
BDBM35714
Purchase
Wt: 384.4
BDBM50052891
Wt: 427.5
BDBM50052893
Wt: 398.4
BDBM50052896
Wt: 413.5
BDBM50052900
Wt: 427.5
BDBM50052902
Wt: 441.5
BDBM50052906
Wt: 399.4
BDBM50052908
Wt: 404.8
BDBM50052909
Wt: 400.4
BDBM50052910
Wt: 452.5
BDBM50052912
Wt: 455.5
BDBM50052915
Wt: 370.4
BDBM50052920
Wt: 385.4
BDBM50052921
Wt: 370.4
BDBM50052928
Displayed 1 to 15 (of 24 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 35714,50052891,50052893,50052896,50052900,50052902,50052906,50052908,50052909,50052910,50052912,50052915,50052920,50052921,50052928   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM50052910
PNG
(CHEMBL118271 | N-[4-(5-Hydroxy-2,3,4,5-tetrahydro-...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(O)c2ccccc12
Show InChI InChI=1S/C25H24N2O3/c1-17-7-2-3-8-20(17)24(29)26-19-14-12-18(13-15-19)25(30)27-16-6-11-23(28)21-9-4-5-10-22(21)27/h2-5,7-10,12-15,23,28H,6,11,16H2,1H3,(H,26,29)
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1.60n/an/an/an/an/an/an/an/a



Teikyo University

Curated by ChEMBL


Assay Description
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 aft...


J Med Chem 60: 4503-4509 (2017)

More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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6.10n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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6.36n/an/an/an/an/an/an/an/a



Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 287: 860-7 (1998)


BindingDB Entry DOI: 10.7270/Q2S46QGC
More data for this
Ligand-Target Pair
Vasopressin receptor


(Homo sapiens (Human))
BDBM50052910
PNG
(CHEMBL118271 | N-[4-(5-Hydroxy-2,3,4,5-tetrahydro-...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(O)c2ccccc12
Show InChI InChI=1S/C25H24N2O3/c1-17-7-2-3-8-20(17)24(29)26-19-14-12-18(13-15-19)25(30)27-16-6-11-23(28)21-9-4-5-10-22(21)27/h2-5,7-10,12-15,23,28H,6,11,16H2,1H3,(H,26,29)
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7.60n/an/an/an/an/an/an/an/a



Teikyo University

Curated by ChEMBL


Assay Description
Displacement of [3H] (Arg8)-vasopressin from human vasopressin V2 receptor expressed in CHOK1 cell membranes after 2 hrs by liquid scintillation coun...


J Med Chem 60: 4503-4509 (2017)

More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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9.42n/an/an/an/an/an/an/an/a



Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 287: 860-7 (1998)


BindingDB Entry DOI: 10.7270/Q2S46QGC
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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9.42n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Company

Curated by ChEMBL


Assay Description
Concentration of the compound which inhibit [3H]-AVP binding to human Vasopressin V2 receptor coded HeLa cells by 50%


J Med Chem 43: 4388-97 (2000)


Article DOI: 10.1021/jm000108p
BindingDB Entry DOI: 10.7270/Q2PG1R04
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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9.70n/an/an/an/an/an/an/an/a



UMR7200 CNRS/Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Binding affinity to vasopressin V2 receptor


J Med Chem 55: 8588-602 (2012)


Article DOI: 10.1021/jm3006146
BindingDB Entry DOI: 10.7270/Q28G8MT5
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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42.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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150n/an/an/an/an/an/an/an/a



Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 287: 860-7 (1998)


BindingDB Entry DOI: 10.7270/Q2S46QGC
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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193n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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195n/an/an/an/an/an/an/an/a



UMR7200 CNRS/Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Binding affinity to vasopressin V1a receptor


J Med Chem 55: 8588-602 (2012)


Article DOI: 10.1021/jm3006146
BindingDB Entry DOI: 10.7270/Q28G8MT5
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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232n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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524n/an/an/an/an/an/an/an/a



Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 287: 860-7 (1998)


BindingDB Entry DOI: 10.7270/Q2S46QGC
More data for this
Ligand-Target Pair
Oxytocin receptor


(HEK293)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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660n/an/an/an/an/an/an/an/a



UMR7200 CNRS/Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Binding affinity to oxytocin receptor


J Med Chem 55: 8588-602 (2012)


Article DOI: 10.1021/jm3006146
BindingDB Entry DOI: 10.7270/Q28G8MT5
More data for this
Ligand-Target Pair
Oxytocin receptor


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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1.55E+3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
Vasopressin V1b receptor


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Second Tokushima Institute of New Drug Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 287: 860-7 (1998)


BindingDB Entry DOI: 10.7270/Q2S46QGC
More data for this
Ligand-Target Pair
Vasopressin receptor


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 301-8 (1997)


BindingDB Entry DOI: 10.7270/Q25T3J1N
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052920
PNG
(CHEMBL331164 | N-[4-(3,4-Dihydro-2H-quinoline-1-ca...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C24H22N2O2/c1-17-7-2-4-10-21(17)23(27)25-20-14-12-19(13-15-20)24(28)26-16-6-9-18-8-3-5-11-22(18)26/h2-5,7-8,10-15H,6,9,16H2,1H3,(H,25,27)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052908
PNG
(CHEMBL420880 | N-[4-(5-Amino-2,3,4,5-tetrahydro-be...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(N)c2ccccc12
Show InChI InChI=1S/C25H25N3O2/c1-17-7-2-3-8-20(17)24(29)27-19-14-12-18(13-15-19)25(30)28-16-6-10-22(26)21-9-4-5-11-23(21)28/h2-5,7-9,11-15,22H,6,10,16,26H2,1H3,(H,27,29)
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n/an/a 390n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052896
PNG
(2-Methyl-N-[4-(3,4,5,6-tetrahydro-2H-benzo[b]azoci...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCCCc2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-9-4-6-12-23(19)25(29)27-22-16-14-21(15-17-22)26(30)28-18-8-2-3-10-20-11-5-7-13-24(20)28/h4-7,9,11-17H,2-3,8,10,18H2,1H3,(H,27,29)
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n/an/a 28n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052902
PNG
(CHEMBL115853 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccc(C)cc3)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-10-12-20(13-11-19)26(31)28-22-16-14-21(15-17-22)27(32)30-18-6-9-24(29(2)3)23-7-4-5-8-25(23)30/h4-5,7-8,10-17,24H,6,9,18H2,1-3H3,(H,28,31)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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n/an/a 12n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052912
PNG
(CHEMBL323802 | N-{4-[5-(Cyanomethyl-methyl-amino)-...)
Show SMILES CN(CC#N)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C28H28N4O2/c1-20-8-3-4-9-23(20)27(33)30-22-15-13-21(14-16-22)28(34)32-18-7-12-25(31(2)19-17-29)24-10-5-6-11-26(24)32/h3-6,8-11,13-16,25H,7,12,18-19H2,1-2H3,(H,30,33)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052906
PNG
(CHEMBL118805 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(cc2)N(C)C(=O)c2ccccc2C)c2ccccc12
Show InChI InChI=1S/C28H31N3O2/c1-20-10-5-6-11-23(20)28(33)30(4)22-17-15-21(16-18-22)27(32)31-19-9-14-25(29(2)3)24-12-7-8-13-26(24)31/h5-8,10-13,15-18,25H,9,14,19H2,1-4H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052915
PNG
(2-Methyl-N-{4-[5-(methyl-propyl-amino)-2,3,4,5-tet...)
Show SMILES CCCN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C29H33N3O2/c1-4-19-31(3)26-14-9-20-32(27-13-8-7-12-25(26)27)29(34)22-15-17-23(18-16-22)30-28(33)24-11-6-5-10-21(24)2/h5-8,10-13,15-18,26H,4,9,14,19-20H2,1-3H3,(H,30,33)
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n/an/a 22n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052921
PNG
(1-Phenyl-3-[4-(2,3,4,5-tetrahydro-benzo[b]azepine-...)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12
Show InChI InChI=1S/C24H23N3O2/c28-23(27-17-7-6-9-18-8-4-5-12-22(18)27)19-13-15-21(16-14-19)26-24(29)25-20-10-2-1-3-11-20/h1-5,8,10-16H,6-7,9,17H2,(H2,25,26,29)
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n/an/a 760n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052928
PNG
(CHEMBL333201 | N-[4-(2,3,4,5-Tetrahydro-benzo[b]az...)
Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H22N2O2/c27-23(19-10-2-1-3-11-19)25-21-15-13-20(14-16-21)24(28)26-17-7-6-9-18-8-4-5-12-22(18)26/h1-5,8,10-16H,6-7,9,17H2,(H,25,27)
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n/an/a 95n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052910
PNG
(CHEMBL118271 | N-[4-(5-Hydroxy-2,3,4,5-tetrahydro-...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(O)c2ccccc12
Show InChI InChI=1S/C25H24N2O3/c1-17-7-2-3-8-20(17)24(29)26-19-14-12-18(13-15-19)25(30)27-16-6-11-23(28)21-9-4-5-10-22(21)27/h2-5,7-10,12-15,23,28H,6,11,16H2,1H3,(H,26,29)
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n/an/a 140n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052900
PNG
(CHEMBL334225 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O2/c1-28(2)23-13-8-18-29(24-12-7-6-11-22(23)24)26(31)20-14-16-21(17-15-20)27-25(30)19-9-4-3-5-10-19/h3-7,9-12,14-17,23H,8,13,18H2,1-2H3,(H,27,30)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052891
PNG
(CHEMBL117566 | N-[4-(3,4-Dihydro-2H-quinoline-1-ca...)
Show SMILES Cc1ccc(C(=O)Nc2ccc(cc2)C(=O)N2CCCc3ccccc23)c(C)c1
Show InChI InChI=1S/C25H24N2O2/c1-17-9-14-22(18(2)16-17)24(28)26-21-12-10-20(11-13-21)25(29)27-15-5-7-19-6-3-4-8-23(19)27/h3-4,6,8-14,16H,5,7,15H2,1-2H3,(H,26,28)
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n/an/a 210n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052909
PNG
(2-Chloro-N-[4-(2,3,4,5-tetrahydro-benzo[b]azepine-...)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12
Show InChI InChI=1S/C24H21ClN2O2/c25-21-10-3-2-9-20(21)23(28)26-19-14-12-18(13-15-19)24(29)27-16-6-5-8-17-7-1-4-11-22(17)27/h1-4,7,9-15H,5-6,8,16H2,(H,26,28)
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n/an/a 29n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]AVP as radioligand in CHO cells


J Med Chem 24: 496-9 (1981)


Article DOI: 10.1021/jm00137a004
BindingDB Entry DOI: 10.7270/Q2K64JTV
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against arginine vasopressin V2 receptor using [3H]AVP as radioligand in rat adrenal medulla


J Med Chem 24: 496-9 (1981)


Article DOI: 10.1021/jm00137a004
BindingDB Entry DOI: 10.7270/Q2K64JTV
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052928
PNG
(CHEMBL333201 | N-[4-(2,3,4,5-Tetrahydro-benzo[b]az...)
Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H22N2O2/c27-23(19-10-2-1-3-11-19)25-21-15-13-20(14-16-21)24(28)26-17-7-6-9-18-8-4-5-12-22(18)26/h1-5,8,10-16H,6-7,9,17H2,(H,25,27)
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n/an/a 70n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052921
PNG
(1-Phenyl-3-[4-(2,3,4,5-tetrahydro-benzo[b]azepine-...)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12
Show InChI InChI=1S/C24H23N3O2/c28-23(27-17-7-6-9-18-8-4-5-12-22(18)27)19-13-15-21(16-14-19)26-24(29)25-20-10-2-1-3-11-20/h1-5,8,10-16H,6-7,9,17H2,(H2,25,26,29)
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n/an/a 180n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052893
PNG
(CHEMBL118922 | N-[4-(5-Ethylamino-2,3,4,5-tetrahyd...)
Show SMILES CCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-3-28-24-12-8-18-30(25-13-7-6-11-23(24)25)27(32)20-14-16-21(17-15-20)29-26(31)22-10-5-4-9-19(22)2/h4-7,9-11,13-17,24,28H,3,8,12,18H2,1-2H3,(H,29,31)
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n/an/a 29n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052920
PNG
(CHEMBL331164 | N-[4-(3,4-Dihydro-2H-quinoline-1-ca...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCc2ccccc12
Show InChI InChI=1S/C24H22N2O2/c1-17-7-2-4-10-21(17)23(27)25-20-14-12-19(13-15-20)24(28)26-16-6-9-18-8-3-5-11-22(18)26/h2-5,7-8,10-15H,6,9,16H2,1H3,(H,25,27)
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n/an/a 200n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052915
PNG
(2-Methyl-N-{4-[5-(methyl-propyl-amino)-2,3,4,5-tet...)
Show SMILES CCCN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C29H33N3O2/c1-4-19-31(3)26-14-9-20-32(27-13-8-7-12-25(26)27)29(34)22-15-17-23(18-16-22)30-28(33)24-11-6-5-10-21(24)2/h5-8,10-13,15-18,26H,4,9,14,19-20H2,1-3H3,(H,30,33)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052912
PNG
(CHEMBL323802 | N-{4-[5-(Cyanomethyl-methyl-amino)-...)
Show SMILES CN(CC#N)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C28H28N4O2/c1-20-8-3-4-9-23(20)27(33)30-22-15-13-21(14-16-22)28(34)32-18-7-12-25(31(2)19-17-29)24-10-5-6-11-26(24)32/h3-6,8-11,13-16,25H,7,12,18-19H2,1-2H3,(H,30,33)
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n/an/a 25n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052909
PNG
(2-Chloro-N-[4-(2,3,4,5-tetrahydro-benzo[b]azepine-...)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCCc2ccccc12
Show InChI InChI=1S/C24H21ClN2O2/c25-21-10-3-2-9-20(21)23(28)26-19-14-12-18(13-15-19)24(29)27-16-6-5-8-17-7-1-4-11-22(17)27/h1-4,7,9-15H,5-6,8,16H2,(H,26,28)
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n/an/a 45n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052908
PNG
(CHEMBL420880 | N-[4-(5-Amino-2,3,4,5-tetrahydro-be...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(N)c2ccccc12
Show InChI InChI=1S/C25H25N3O2/c1-17-7-2-3-8-20(17)24(29)27-19-14-12-18(13-15-19)25(30)28-16-6-10-22(26)21-9-4-5-11-23(21)28/h2-5,7-9,11-15,22H,6,10,16,26H2,1H3,(H,27,29)
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n/an/a 32n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052910
PNG
(CHEMBL118271 | N-[4-(5-Hydroxy-2,3,4,5-tetrahydro-...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC(O)c2ccccc12
Show InChI InChI=1S/C25H24N2O3/c1-17-7-2-3-8-20(17)24(29)26-19-14-12-18(13-15-19)25(30)27-16-6-11-23(28)21-9-4-5-10-22(21)27/h2-5,7-10,12-15,23,28H,6,11,16H2,1H3,(H,26,29)
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n/an/a 29n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052902
PNG
(CHEMBL115853 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccc(C)cc3)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-10-12-20(13-11-19)26(31)28-22-16-14-21(15-17-22)27(32)30-18-6-9-24(29(2)3)23-7-4-5-8-25(23)30/h4-5,7-8,10-17,24H,6,9,18H2,1-3H3,(H,28,31)
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n/an/a 44n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052906
PNG
(CHEMBL118805 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(cc2)N(C)C(=O)c2ccccc2C)c2ccccc12
Show InChI InChI=1S/C28H31N3O2/c1-20-10-5-6-11-23(20)28(33)30(4)22-17-15-21(16-18-22)27(32)31-19-9-14-25(29(2)3)24-12-7-8-13-26(24)31/h5-8,10-13,15-18,25H,9,14,19H2,1-4H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 Receptor


(Rattus norvegicus (Rat))
BDBM50052900
PNG
(CHEMBL334225 | N-[4-(5-Dimethylamino-2,3,4,5-tetra...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O2/c1-28(2)23-13-8-18-29(24-12-7-6-11-22(23)24)26(31)20-14-16-21(17-15-20)27-25(30)19-9-4-3-5-10-19/h3-7,9-12,14-17,23H,8,13,18H2,1-2H3,(H,27,30)
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n/an/a 27n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from its AVP-V2 receptor binding site in rat kidney


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052896
PNG
(2-Methyl-N-[4-(3,4,5,6-tetrahydro-2H-benzo[b]azoci...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1CCCCCc2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-9-4-6-12-23(19)25(29)27-22-16-14-21(15-17-22)26(30)28-18-8-2-3-10-20-11-5-7-13-24(20)28/h4-7,9,11-17H,2-3,8,10,18H2,1H3,(H,27,29)
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n/an/a 410n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052893
PNG
(CHEMBL118922 | N-[4-(5-Ethylamino-2,3,4,5-tetrahyd...)
Show SMILES CCNC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-3-28-24-12-8-18-30(25-13-7-6-11-23(24)25)27(32)20-14-16-21(17-15-20)29-26(31)22-10-5-4-9-19(22)2/h4-7,9-11,13-17,24,28H,3,8,12,18H2,1-2H3,(H,29,31)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
AVPR1A


(RAT)
BDBM50052891
PNG
(CHEMBL117566 | N-[4-(3,4-Dihydro-2H-quinoline-1-ca...)
Show SMILES Cc1ccc(C(=O)Nc2ccc(cc2)C(=O)N2CCCc3ccccc23)c(C)c1
Show InChI InChI=1S/C25H24N2O2/c1-17-9-14-22(18(2)16-17)24(28)26-21-12-10-20(11-13-21)25(29)27-15-5-7-19-6-3-4-8-23(19)27/h3-4,6,8-14,16H,5,7,15H2,1-2H3,(H,26,28)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Otsuka Pharmaceutical Co.

Curated by ChEMBL


Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver


J Med Chem 39: 3547-55 (1996)


Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT
More data for this
Ligand-Target Pair
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM35714
PNG
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)
Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
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n/an/a 12n/an/an/an/a7.44



Otsuka Pharmaceutical Co., Ltd



Assay Description
After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C...


Bioorg Med Chem 7: 1743-54 (1999)


Article DOI: 10.1080/14756360600991017
BindingDB Entry DOI: 10.7270/Q2W957JR
More data for this
Ligand-Target Pair
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