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4 similar compounds to monomer 17636

Wt: 281.2
BDBM35911
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Wt: 280.2
BDBM85514
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Wt: 299.2
BDBM50371732
Wt: 325.2
BDBM50371739

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 35911,85514,50371732,50371739   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM85514
PNG
(CAS_530-78-9 | Flufenamate | NSC_27881)
Show SMILES [O-]C(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)/p-1
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
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PC sid
UniChem

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PubMed
3.00E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 96: 7563-8 (1999)

More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM85514
PNG
(CAS_530-78-9 | Flufenamate | NSC_27881)
Show SMILES [O-]C(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)/p-1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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AffyNet 
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PC cid
PC sid
UniChem

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PubMed
9.30E+3n/an/an/an/an/an/an/an/a



St. Bartholomew's and the Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 96: 7563-8 (1999)

More data for this
Ligand-Target Pair
Myeloperoxidase (MPO)


(Homo sapiens (Human))
BDBM50371739
PNG
(CHEMBL402448)
Show SMILES OC(=O)c1cccc(Nc2cccc(c2)C(F)(F)F)c1C(O)=O
Show InChI InChI=1S/C15H10F3NO4/c16-15(17,18)8-3-1-4-9(7-8)19-11-6-2-5-10(13(20)21)12(11)14(22)23/h1-7,19H,(H,20,21)(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ Libre de Bruxelles

Curated by ChEMBL


Assay Description
Inhibition of chlorinating activity of recombinant myeloperoxidase by taurine assay


Bioorg Med Chem 16: 1702-20 (2008)

More data for this
Ligand-Target Pair
Myeloperoxidase (MPO)


(Homo sapiens (Human))
BDBM50371732
PNG
(CHEMBL271973)
Show SMILES OC(=O)c1cc(F)ccc1Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F4NO2/c15-9-4-5-12(11(7-9)13(20)21)19-10-3-1-2-8(6-10)14(16,17)18/h1-7,19H,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Universit£ Libre de Bruxelles

Curated by ChEMBL


Assay Description
Inhibition of chlorinating activity of recombinant myeloperoxidase by taurine assay


Bioorg Med Chem 16: 1702-20 (2008)

More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM35911
PNG
(flufenamic acid analogue, 37)
Show SMILES OC(=O)c1ccccc1Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-5-7-10(8-6-9)18-12-4-2-1-3-11(12)13(19)20/h1-8,18H,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC cid
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Patents


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Article
PubMed
n/an/an/an/a 3.90E+4n/an/a7.223



St. Jude Research Hospital



Assay Description
AR functionality was determined by fluorescence polarization (excitation @485 nm, emission @ 530 nm) assay, which measures fluorescently labeled SRC2...


ACS Chem Biol 4: 834-43 (2009)

More data for this
Ligand-Target Pair