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9 similar compounds to monomer 50433053

Compile data set for download or QSAR
Wt: 356.1
BDBM42298
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Wt: 343.1
BDBM50396827
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Wt: 278.2
BDBM50433068
Wt: 310.2
BDBM50433054
Wt: 357.1
BDBM50433056
Wt: 442.2
BDBM50433061
Wt: 476.2
BDBM50433062
Wt: 490.3
BDBM50433065
Wt: 400.1
BDBM50433066

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 42298,50396827,50433068,50433054,50433056,50433061,50433062,50433065,50433066   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50396827
PNG
(CHEMBL1712297)
Show SMILES ONC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN2O5/c13-7-1-2-9-8(5-7)12(19-3-4-20-12)11(17)15(9)6-10(16)14-18/h1-2,5,18H,3-4,6H2,(H,14,16)
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PubMed
2.79E+3n/an/an/an/an/an/an/an/a



Shandong Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate by Dixon method


Bioorg Med Chem Lett 22: 5863-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.086
BindingDB Entry DOI: 10.7270/Q2VD70KS
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50396827
PNG
(CHEMBL1712297)
Show SMILES ONC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN2O5/c13-7-1-2-9-8(5-7)12(19-3-4-20-12)11(17)15(9)6-10(16)14-18/h1-2,5,18H,3-4,6H2,(H,14,16)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Shandong Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 mins


Bioorg Med Chem Lett 22: 5863-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.086
BindingDB Entry DOI: 10.7270/Q2VD70KS
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50433054
PNG
(CHEMBL2376114)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCCO2)c2cc(F)ccc12
Show InChI InChI=1S/C14H15FN2O5/c15-9-3-4-11-10(7-9)14(21-5-1-2-6-22-14)13(19)17(11)8-12(18)16-20/h3-4,7,20H,1-2,5-6,8H2,(H,16,18)
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n/an/a 1.52E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase-N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50433056
PNG
(CHEMBL2376110)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C13H13BrN2O5/c14-8-2-3-10-9(6-8)13(20-4-1-5-21-13)12(18)16(10)7-11(17)15-19/h2-3,6,19H,1,4-5,7H2,(H,15,17)
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n/an/a 1.97E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase-N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50396827
PNG
(CHEMBL1712297)
Show SMILES ONC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN2O5/c13-7-1-2-9-8(5-7)12(19-3-4-20-12)11(17)15(9)6-10(16)14-18/h1-2,5,18H,3-4,6H2,(H,14,16)
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n/an/a 1.24E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of aminopeptidase-N in human ES2 cells using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured a...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50396827
PNG
(CHEMBL1712297)
Show SMILES ONC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C12H11BrN2O5/c13-7-1-2-9-8(5-7)12(19-3-4-20-12)11(17)15(9)6-10(16)14-18/h1-2,5,18H,3-4,6H2,(H,14,16)
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n/an/a 360n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433062
PNG
(CHEMBL2376102)
Show SMILES ONC(=O)C(NC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12)c1ccccc1
Show InChI InChI=1S/C20H18BrN3O6/c21-13-6-7-15-14(10-13)20(29-8-9-30-20)19(27)24(15)11-16(25)22-17(18(26)23-28)12-4-2-1-3-5-12/h1-7,10,17,28H,8-9,11H2,(H,22,25)(H,23,26)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433065
PNG
(CHEMBL2376117)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C21H20BrN3O6/c22-14-6-7-17-15(11-14)21(30-8-9-31-21)20(28)25(17)12-18(26)23-16(19(27)24-29)10-13-4-2-1-3-5-13/h1-7,11,16,29H,8-10,12H2,(H,23,26)(H,24,27)/t16-/m0/s1
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n/an/a 2.64E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433066
PNG
(CHEMBL2376116)
Show SMILES ONC(=O)CNC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C14H14BrN3O6/c15-8-1-2-10-9(5-8)14(23-3-4-24-14)13(21)18(10)7-12(20)16-6-11(19)17-22/h1-2,5,22H,3-4,6-7H2,(H,16,20)(H,17,19)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433054
PNG
(CHEMBL2376114)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCCO2)c2cc(F)ccc12
Show InChI InChI=1S/C14H15FN2O5/c15-9-3-4-11-10(7-9)14(21-5-1-2-6-22-14)13(19)17(11)8-12(18)16-20/h3-4,7,20H,1-2,5-6,8H2,(H,16,18)
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n/an/a 4.06E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433068
PNG
(CHEMBL2376111)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCO2)c2ccccc12
Show InChI InChI=1S/C13H14N2O5/c16-11(14-18)8-15-10-5-2-1-4-9(10)13(12(15)17)19-6-3-7-20-13/h1-2,4-5,18H,3,6-8H2,(H,14,16)
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n/an/a 2.66E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433056
PNG
(CHEMBL2376110)
Show SMILES ONC(=O)CN1C(=O)C2(OCCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C13H13BrN2O5/c14-8-2-3-10-9(6-8)13(20-4-1-5-21-13)12(18)16(10)7-11(17)15-19/h2-3,6,19H,1,4-5,7H2,(H,15,17)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (Human))
BDBM42298
PNG
(2-(5'-bromo-2'-keto-spiro[1,3-dioxane-2,3'-indolin...)
Show SMILES COC(=O)CN1C(=O)C2(OCCCO2)c2cc(Br)ccc12
Show InChI InChI=1S/C14H14BrNO5/c1-19-12(17)8-16-11-4-3-9(15)7-10(11)14(13(16)18)20-5-2-6-21-14/h3-4,7H,2,5-6,8H2,1H3
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PCBioAssay
n/an/an/an/a>1.00E+4n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q23J3BC8
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50433061
PNG
(CHEMBL2376103)
Show SMILES CC(C)[C@H](NC(=O)CN1C(=O)C2(OCCO2)c2cc(Br)ccc12)C(=O)NO
Show InChI InChI=1S/C17H20BrN3O6/c1-9(2)14(15(23)20-25)19-13(22)8-21-12-4-3-10(18)7-11(12)17(16(21)24)26-5-6-27-17/h3-4,7,9,14,25H,5-6,8H2,1-2H3,(H,19,22)(H,20,23)/t14-/m0/s1
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n/an/a 2.26E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney microsome aminopeptidase-N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured...


Bioorg Med Chem 21: 2663-70 (2013)


Article DOI: 10.1016/j.bmc.2012.06.024
BindingDB Entry DOI: 10.7270/Q2J67J8H
More data for this
Ligand-Target Pair