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4 similar compounds to monomer 4301

Compile data set for download or QSAR
Wt: 188.1
BDBM4355
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Wt: 188.1
BDBM50046753
Wt: 204.1
BDBM50046755
Wt: 220.1
BDBM50046757

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 4355,50046753,50046755,50046757   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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Article
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1.02E+5n/an/an/an/an/an/an/an/a



University of Heidelberg

Curated by ChEMBL


Assay Description
Inhibition of human thrombin using Boc-VPR-AMC as substrate compound preincubated for 15 mins before substrate addition measured up to 10 mins by spe...


Bioorg Med Chem 19: 7318-37 (2011)


Article DOI: 10.1016/j.bmc.2011.10.061
BindingDB Entry DOI: 10.7270/Q2474B8H
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/an/an/a 1.50E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
KEGG

UniProtKB/TrEMBL

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n/an/an/an/a 1.34E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
Phospholipase C, gamma 1


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
PDB
MMDB

B.MOAD
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PCBioAssay
n/an/a 1.22E+5n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2NC5ZV0
More data for this
Ligand-Target Pair
lens epithelium-derived growth factor p75


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 5.16E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2Q52N9H
More data for this
Ligand-Target Pair
lens epithelium-derived growth factor p75


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 9.60E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2KD1WKS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046755
PNG
(2-Cyano-3-(3,5-dihydroxy-phenyl)-acrylamide | CHEM...)
Show SMILES NC(=O)C(=C\c1cc(O)cc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)1-6-2-8(13)4-9(14)3-6/h1-4,13-14H,(H2,12,15)/b7-1+
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n/an/a 5.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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CHEMBL
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PubMed
n/an/a 1.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGFR in human A431 cells


J Nat Prod 55: 1529-1560 (1992)


Article DOI: 10.1021/np50089a001
BindingDB Entry DOI: 10.7270/Q2J966CC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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n/an/a 8.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 32: 2344-52 (1989)


Article DOI: 10.1021/jm00130a020
BindingDB Entry DOI: 10.7270/Q2G44NHF
More data for this
Ligand-Target Pair
Phospholipase C-beta-3


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 1.22E+5n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2S46QKQ
More data for this
Ligand-Target Pair