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41 similar compounds to monomer 4492

Compile data set for download or QSAR
Wt: 339.7
BDBM4446
Wt: 320.3
BDBM4453
Wt: 319.3
BDBM4459
Wt: 355.7
BDBM4462
Wt: 390.2
BDBM4463
Wt: 353.8
BDBM4466
Wt: 388.2
BDBM4498
Wt: 377.2
BDBM4499
Wt: 344.1
BDBM4500
Wt: 344.1
BDBM4501
Wt: 344.1
BDBM4502
Wt: 374.2
BDBM4503
Wt: 402.2
BDBM4504
Wt: 458.3
BDBM4505
Wt: 339.7
BDBM4506
Displayed 1 to 15 (of 41 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 4446,4453,4459,4462,4463,4466,4498,4499,4500,4501,4502,4503,4504,4505,4506   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4459
PNG
(4-(4-Methylphenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C19H17N3O2/c1-12-4-6-14(7-5-12)22-19-13(10-20)11-21-16-9-18(24-3)17(23-2)8-15(16)19/h4-9,11H,1-3H3,(H,21,22)
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Article
PubMed
n/an/a 2.73E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4462
PNG
(4-(3-Chloro-4-hydroxyphenylamino)-6,7-dimethoxyqui...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H14ClN3O3/c1-24-16-6-12-14(7-17(16)25-2)21-9-10(8-20)18(12)22-11-3-4-15(23)13(19)5-11/h3-7,9,23H,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 9.12E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4463
PNG
(4-(3,5-Dichloro-4-hydroxyphenylamino)-6,7-dimethox...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cc(Cl)c(O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H13Cl2N3O3/c1-25-15-5-11-14(6-16(15)26-2)22-8-9(7-21)17(11)23-10-3-12(19)18(24)13(20)4-10/h3-6,8,24H,1-2H3,(H,22,23)
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Article
PubMed
n/an/a 3.15E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4466
PNG
(4-(3-Chloro-4-methylphenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(C)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C19H16ClN3O2/c1-11-4-5-13(6-15(11)20)23-19-12(9-21)10-22-16-8-18(25-3)17(24-2)7-14(16)19/h4-8,10H,1-3H3,(H,22,23)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4498
PNG
(4-(2,4-Dichlorophenylmethylamino)-6,7-dimethoxy-3-...)
Show SMILES COc1cc2ncc(C#N)c(N(C)c3ccc(Cl)cc3Cl)c2cc1OC
Show InChI InChI=1S/C19H15Cl2N3O2/c1-24(16-5-4-12(20)6-14(16)21)19-11(9-22)10-23-15-8-18(26-3)17(25-2)7-13(15)19/h4-8,10H,1-3H3
PDB
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KEGG

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Article
PubMed
n/an/an/an/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4499
PNG
(4-[(2,4-Dichlorophenyl)amino]-6,7-dimethoxy-3-quin...)
Show SMILES COc1cc2ncc(C=O)c(Nc3ccc(Cl)cc3Cl)c2cc1OC
Show InChI InChI=1S/C18H14Cl2N2O3/c1-24-16-6-12-15(7-17(16)25-2)21-8-10(9-23)18(12)22-14-4-3-11(19)5-13(14)20/h3-9H,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 250n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4500
PNG
(3-quinolinecarbonitrile deriv. 2c | 4-[(2,4-Dichlo...)
Show SMILES COc1cccc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c12
Show InChI InChI=1S/C17H11Cl2N3O/c1-23-15-4-2-3-14-16(15)17(10(8-20)9-21-14)22-13-6-5-11(18)7-12(13)19/h2-7,9H,1H3,(H,21,22)
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Article
PubMed
n/an/a 1.20E+3n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4501
PNG
(3-quinolinecarbonitrile deriv. 2d | 4-[(2,4-Dichlo...)
Show SMILES COc1ccc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2c1
Show InChI InChI=1S/C17H11Cl2N3O/c1-23-12-3-5-15-13(7-12)17(10(8-20)9-21-15)22-16-4-2-11(18)6-14(16)19/h2-7,9H,1H3,(H,21,22)
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Article
PubMed
n/an/a 320n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4502
PNG
(3-quinolinecarbonitrile deriv. 2e | 4-[(2,4-Dichlo...)
Show SMILES COc1ccc2c(Nc3ccc(Cl)cc3Cl)c(cnc2c1)C#N
Show InChI InChI=1S/C17H11Cl2N3O/c1-23-12-3-4-13-16(7-12)21-9-10(8-20)17(13)22-15-5-2-11(18)6-14(15)19/h2-7,9H,1H3,(H,21,22)
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Article
PubMed
n/an/a 200n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4503
PNG
(3-quinolinecarbonitrile deriv. 2g | 4-[(2,4-Dichlo...)
Show SMILES COc1cc(OC)c2c(Nc3ccc(Cl)cc3Cl)c(cnc2c1)C#N
Show InChI InChI=1S/C18H13Cl2N3O2/c1-24-12-6-15-17(16(7-12)25-2)18(10(8-21)9-22-15)23-14-4-3-11(19)5-13(14)20/h3-7,9H,1-2H3,(H,22,23)
PDB
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Article
PubMed
n/an/an/an/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4504
PNG
(3-quinolinecarbonitrile deriv. 2i | 4-[(2,4-Dichlo...)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2cc1OCC
Show InChI InChI=1S/C20H17Cl2N3O2/c1-3-26-18-8-14-17(9-19(18)27-4-2)24-11-12(10-23)20(14)25-16-6-5-13(21)7-15(16)22/h5-9,11H,3-4H2,1-2H3,(H,24,25)
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PubMed
n/an/a 11n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4505
PNG
(3-quinolinecarbonitrile deriv. 2j | 4-[(2,4-Dichlo...)
Show SMILES CCCCOc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2cc1OCCCC
Show InChI InChI=1S/C24H25Cl2N3O2/c1-3-5-9-30-22-12-18-21(13-23(22)31-10-6-4-2)28-15-16(14-27)24(18)29-20-8-7-17(25)11-19(20)26/h7-8,11-13,15H,3-6,9-10H2,1-2H3,(H,28,29)
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PubMed
n/an/a 160n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM4506
PNG
(4-(2-Chlorophenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccccc3Cl)c2cc1OC
Show InChI InChI=1S/C18H14ClN3O2/c1-23-16-7-12-15(8-17(16)24-2)21-10-11(9-20)18(12)22-14-6-4-3-5-13(14)19/h3-8,10H,1-2H3,(H,21,22)
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n/an/a 95n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)


Article DOI: 10.1021/jm000420z
BindingDB Entry DOI: 10.7270/Q2Z31WVP
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4446
PNG
(4-(3-Chlorophenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H14ClN3O2/c1-23-16-7-14-15(8-17(16)24-2)21-10-11(9-20)18(14)22-13-5-3-4-12(19)6-13/h3-8,10H,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 180n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4453
PNG
(4-(3-Aminophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(N)c3)c2cc1OC
Show InChI InChI=1S/C18H16N4O2/c1-23-16-7-14-15(8-17(16)24-2)21-10-11(9-19)18(14)22-13-5-3-4-12(20)6-13/h3-8,10H,20H2,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 820n/an/an/an/a7.422



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4453
PNG
(4-(3-Aminophenylamino)-6,7-dimethoxyquinoline-3-ca...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(N)c3)c2cc1OC
Show InChI InChI=1S/C18H16N4O2/c1-23-16-7-14-15(8-17(16)24-2)21-10-11(9-19)18(14)22-13-5-3-4-12(20)6-13/h3-8,10H,20H2,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 813n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4463
PNG
(4-(3,5-Dichloro-4-hydroxyphenylamino)-6,7-dimethox...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cc(Cl)c(O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H13Cl2N3O3/c1-25-15-5-11-14(6-16(15)26-2)22-8-9(7-21)17(11)23-10-3-12(19)18(24)13(20)4-10/h3-6,8,24H,1-2H3,(H,22,23)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4466
PNG
(4-(3-Chloro-4-methylphenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(C)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C19H16ClN3O2/c1-11-4-5-13(6-15(11)20)23-19-12(9-21)10-22-16-8-18(25-3)17(24-2)7-14(16)19/h4-8,10H,1-3H3,(H,22,23)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4459
PNG
(4-(4-Methylphenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C19H17N3O2/c1-12-4-6-14(7-5-12)22-19-13(10-20)11-21-16-9-18(24-3)17(23-2)8-15(16)19/h4-9,11H,1-3H3,(H,21,22)
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n/an/a 2.75E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4446
PNG
(4-(3-Chlorophenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H14ClN3O2/c1-23-16-7-14-15(8-17(16)24-2)21-10-11(9-20)18(14)22-13-5-3-4-12(19)6-13/h3-8,10H,1-2H3,(H,21,22)
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Article
PubMed
n/an/a 182n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA


Eur J Med Chem 43: 781-91 (2008)


Article DOI: 10.1016/j.ejmech.2007.06.006
BindingDB Entry DOI: 10.7270/Q2DJ5GXN
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4462
PNG
(4-(3-Chloro-4-hydroxyphenylamino)-6,7-dimethoxyqui...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(O)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H14ClN3O3/c1-24-16-6-12-14(7-17(16)25-2)21-9-10(8-20)18(12)22-11-3-4-15(23)13(19)5-11/h3-7,9,23H,1-2H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.04E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...


J Med Chem 43: 3244-56 (2000)


Article DOI: 10.1021/jm000206a
BindingDB Entry DOI: 10.7270/Q22V2D9M
More data for this
Ligand-Target Pair