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38 similar compounds to monomer 4552

Wt: 600.5
BDBM4518
Wt: 487.3
BDBM4519
Wt: 487.3
BDBM4520
Wt: 500.4
BDBM4521
Wt: 404.2
BDBM4525
Wt: 418.2
BDBM4526
Wt: 432.3
BDBM4527
Wt: 482.9
BDBM4542
Wt: 517.4
BDBM4543
Wt: 496.9
BDBM4545
Wt: 496.9
BDBM4547
Wt: 517.4
BDBM4548
Wt: 503.3
BDBM4549
Wt: 531.4
BDBM4550
Wt: 545.4
BDBM4551
Displayed 1 to 15 (of 38 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 4518,4519,4520,4521,4525,4526,4527,4542,4543,4545,4547,4548,4549,4550,4551   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4542
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 2b | ...)
Show SMILES COc1ccc(Cl)c(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c1
Show InChI InChI=1S/C25H27ClN4O4/c1-31-18-4-5-20(26)22(12-18)29-25-17(15-27)16-28-21-14-24(23(32-2)13-19(21)25)34-9-3-6-30-7-10-33-11-8-30/h4-5,12-14,16H,3,6-11H2,1-2H3,(H,28,29)
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PubMed
n/an/a 1.60n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4525
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 1c | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C19H15Cl2N3O3/c1-25-16-7-15(12(20)5-13(16)21)24-19-10(8-22)9-23-14-6-18(27-3)17(26-2)4-11(14)19/h4-7,9H,1-3H3,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src protein tryrosine kinase


Bioorg Med Chem Lett 13: 2977-80 (2003)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4548
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 18 | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OCCCN4CCOCC4)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H26Cl2N4O4/c1-32-22-13-21(18(26)11-19(22)27)30-25-16(14-28)15-29-20-12-23(33-2)24(10-17(20)25)35-7-3-4-31-5-8-34-9-6-31/h10-13,15H,3-9H2,1-2H3,(H,29,30)
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PubMed
n/an/a 28n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4549
PNG
(4-Phenylamino 3-quinolinecarbonitrile deriv. 26 | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C24H24Cl2N4O4/c1-31-21-12-20(17(25)10-18(21)26)29-24-15(13-27)14-28-19-11-23(22(32-2)9-16(19)24)34-8-5-30-3-6-33-7-4-30/h9-12,14H,3-8H2,1-2H3,(H,28,29)
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n/an/a 2.30n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4550
PNG
(4-Phenylamino 3-quinolinecarbonitrile deriv. 27 | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C26H28Cl2N4O4/c1-33-23-14-22(19(27)12-20(23)28)31-26-17(15-29)16-30-21-13-25(24(34-2)11-18(21)26)36-8-4-3-5-32-6-9-35-10-7-32/h11-14,16H,3-10H2,1-2H3,(H,30,31)
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n/an/a 1.30n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4551
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 28 | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C27H30Cl2N4O4/c1-34-24-15-23(20(28)13-21(24)29)32-27-18(16-30)17-31-22-14-26(25(35-2)12-19(22)27)37-9-5-3-4-6-33-7-10-36-11-8-33/h12-15,17H,3-11H2,1-2H3,(H,31,32)
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n/an/a 2.5n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4518
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 23 | ...)
Show SMILES Clc1ccc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OCCCN4CCOCC4)cc23)C#N)c(Cl)c1
Show InChI InChI=1S/C30H35Cl2N5O4/c31-23-3-4-26(25(32)17-23)35-30-22(20-33)21-34-27-19-29(41-12-2-6-37-9-15-39-16-10-37)28(18-24(27)30)40-11-1-5-36-7-13-38-14-8-36/h3-4,17-19,21H,1-2,5-16H2,(H,34,35)
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n/an/a 19n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4519
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 24 | ...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H24Cl2N4O3/c1-31-22-13-21-18(12-23(22)33-8-2-5-30-6-9-32-10-7-30)24(16(14-27)15-28-21)29-20-4-3-17(25)11-19(20)26/h3-4,11-13,15H,2,5-10H2,1H3,(H,28,29)
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n/an/a 220n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4520
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 25 | ...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C24H24Cl2N4O3/c1-31-22-12-18-21(13-23(22)33-8-2-5-30-6-9-32-10-7-30)28-15-16(14-27)24(18)29-20-4-3-17(25)11-19(20)26/h3-4,11-13,15H,2,5-10H2,1H3,(H,28,29)
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PubMed
n/an/a 3.80n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4521
PNG
(3-quinolinecarbonitrile 3 | 4-Phenylamino-3-quinol...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCN(C)CC1)C#N
Show InChI InChI=1S/C25H27Cl2N5O2/c1-31-7-9-32(10-8-31)6-3-11-34-24-14-22-19(13-23(24)33-2)25(17(15-28)16-29-22)30-21-5-4-18(26)12-20(21)27/h4-5,12-14,16H,3,6-11H2,1-2H3,(H,29,30)
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PubMed
n/an/a 8.70n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 822-33 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4525
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 1c | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C19H15Cl2N3O3/c1-25-16-7-15(12(20)5-13(16)21)24-19-10(8-22)9-23-14-6-18(27-3)17(26-2)4-11(14)19/h4-7,9H,1-3H3,(H,23,24)
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n/an/a 4.30n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4526
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 1d | ...)
Show SMILES CCOc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C20H17Cl2N3O3/c1-4-28-17-8-16(13(21)6-14(17)22)25-20-11(9-23)10-24-15-7-19(27-3)18(26-2)5-12(15)20/h5-8,10H,4H2,1-3H3,(H,24,25)
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PubMed
n/an/a 1.20E+3n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4527
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 1e | ...)
Show SMILES CCCOc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl2N3O3/c1-4-5-29-18-9-17(14(22)7-15(18)23)26-21-12(10-24)11-25-16-8-20(28-3)19(27-2)6-13(16)21/h6-9,11H,4-5H2,1-3H3,(H,25,26)
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PubMed
n/an/a>5.00E+3n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4520
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 25 | ...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C24H24Cl2N4O3/c1-31-22-12-18-21(13-23(22)33-8-2-5-30-6-9-32-10-7-30)28-15-16(14-27)24(18)29-20-4-3-17(25)11-19(20)26/h3-4,11-13,15H,2,5-10H2,1H3,(H,28,29)
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PubMed
n/an/a 3.80n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4543
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 2c | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H26Cl2N4O4/c1-32-22-13-21(18(26)11-19(22)27)30-25-16(14-28)15-29-20-12-24(23(33-2)10-17(20)25)35-7-3-4-31-5-8-34-9-6-31/h10-13,15H,3-9H2,1-2H3,(H,29,30)
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PubMed
n/an/a 0.800n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4545
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 2e | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(C)cc1Cl
Show InChI InChI=1S/C26H29ClN4O4/c1-17-11-20(27)23(32-2)13-21(17)30-26-18(15-28)16-29-22-14-25(24(33-3)12-19(22)26)35-8-4-5-31-6-9-34-10-7-31/h11-14,16H,4-10H2,1-3H3,(H,29,30)
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n/an/a 1.20n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4521
PNG
(3-quinolinecarbonitrile 3 | 4-Phenylamino-3-quinol...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCN(C)CC1)C#N
Show InChI InChI=1S/C25H27Cl2N5O2/c1-31-7-9-32(10-8-31)6-3-11-34-24-14-22-19(13-23(24)33-2)25(17(15-28)16-29-22)30-21-5-4-18(26)12-20(21)27/h4-5,12-14,16H,3,6-11H2,1-2H3,(H,29,30)
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n/an/a 8.70n/an/an/an/a7.530



Wyeth Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


Bioorg Med Chem Lett 12: 2011-4 (2002)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM4547
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 2g | ...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1C
Show InChI InChI=1S/C26H29ClN4O4/c1-17-11-20(27)22(14-23(17)32-2)30-26-18(15-28)16-29-21-13-25(24(33-3)12-19(21)26)35-8-4-5-31-6-9-34-10-7-31/h11-14,16H,4-10H2,1-3H3,(H,29,30)
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Article
PubMed
n/an/a 1.10n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


J Med Chem 44: 3965-77 (2001)

More data for this
Ligand-Target Pair