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142 similar compounds to monomer 156793

Compile data set for download or QSAR
Wt: 422.4
BDBM47277
Wt: 391.4
BDBM47319
Wt: 426.4
BDBM156854
Wt: 391.4
BDBM47316
Wt: 391.4
BDBM47331
Wt: 492.8
BDBM156784
Wt: 426.4
BDBM156785
Wt: 426.4
BDBM156788
Wt: 426.4
BDBM156789
Wt: 442.8
BDBM156885
Wt: 460.9
BDBM156984
Wt: 424.8
BDBM156986
Wt: 445.2
BDBM156987
Wt: 459.3
BDBM156790
Wt: 422.4
BDBM156792
Displayed 1 to 15 (of 142 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 47277,47319,156854,47316,47331,156784,156785,156788,156789,156885,156984,156986,156987,156790,156792   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47316
PNG
(US9029559, 215)
Show SMILES COc1ccc(nc1-c1ccncc1)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H21N3O4/c1-14-3-5-15(6-4-14)18(13-20(26)27)25-22(28)17-7-8-19(29-2)21(24-17)16-9-11-23-12-10-16/h3-12,18H,13H2,1-2H3,(H,25,28)(H,26,27)/t18-/m0/s1
PDB

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UniChem

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US Patent
n/an/a 9.66E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156987
PNG
(US9029559, 430)
Show SMILES COc1ccc(nc1-c1ccccc1Cl)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C22H18Cl2N2O4/c1-30-19-11-10-17(25-21(19)14-7-3-5-9-16(14)24)22(29)26-18(12-20(27)28)13-6-2-4-8-15(13)23/h2-11,18H,12H2,1H3,(H,26,29)(H,27,28)/t18-/m0/s1
PDB

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US Patent
n/an/a 147n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47331
PNG
(US9029559, 365)
Show SMILES COc1ccc(nc1-c1ccncc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C22H21N3O4/c1-14-5-3-4-6-16(14)18(13-20(26)27)25-22(28)17-7-8-19(29-2)21(24-17)15-9-11-23-12-10-15/h3-12,18H,13H2,1-2H3,(H,25,28)(H,26,27)/t18-/m0/s1
PDB

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US Patent
n/an/a 5.45E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156784
PNG
(US9029559, 211)
Show SMILES COc1ccc(nc1-c1cc(ccc1Cl)C(F)(F)F)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H20ClF3N2O4/c1-13-3-5-14(6-4-13)19(12-21(31)32)30-23(33)18-9-10-20(34-2)22(29-18)16-11-15(24(26,27)28)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,30,33)(H,31,32)/t19-/m0/s1
PDB

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US Patent
n/an/a 421n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156785
PNG
(US9029559, 212)
Show SMILES COc1ccc(nc1-c1cccc(F)c1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20F2N2O4/c1-13-14(7-5-9-16(13)24)22-20(31-2)11-10-18(26-22)23(30)27-19(12-21(28)29)15-6-3-4-8-17(15)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 150n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156788
PNG
(US9029559, 217)
Show SMILES COc1ccc(nc1-c1cccc(F)c1F)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H20F2N2O4/c1-13-6-8-14(9-7-13)18(12-20(28)29)27-23(30)17-10-11-19(31-2)22(26-17)15-4-3-5-16(24)21(15)25/h3-11,18H,12H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1
PDB

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US Patent
n/an/a 90.2n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156789
PNG
(US9029559, 218)
Show SMILES COc1ccc(nc1-c1cc(F)ccc1F)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H20F2N2O4/c1-13-3-5-14(6-4-13)19(12-21(28)29)27-23(30)18-9-10-20(31-2)22(26-18)16-11-15(24)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 99.8n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156790
PNG
(US9029559, 219)
Show SMILES COc1ccc(nc1-c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H20Cl2N2O4/c1-13-3-5-14(6-4-13)19(12-21(28)29)27-23(30)18-9-10-20(31-2)22(26-18)16-11-15(24)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 910n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156792
PNG
(US9029559, 221)
Show SMILES COc1ccc(nc1-c1ccc(F)cc1C)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23FN2O4/c1-14-4-6-16(7-5-14)20(13-22(28)29)27-24(30)19-10-11-21(31-3)23(26-19)18-9-8-17(25)12-15(18)2/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 239n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156854
PNG
(US9029559, 288)
Show SMILES COc1ccc(nc1-c1ccc(F)cc1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20F2N2O4/c1-13-11-14(24)7-8-15(13)22-20(31-2)10-9-18(26-22)23(30)27-19(12-21(28)29)16-5-3-4-6-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 394n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47277
PNG
(BDB47277 | US9029559, 289)
Show SMILES COc1ccc(nc1-c1cccc(C)c1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C24H23FN2O4/c1-14-7-6-9-16(15(14)2)23-21(31-3)12-11-19(26-23)24(30)27-20(13-22(28)29)17-8-4-5-10-18(17)25/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 52.8n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156885
PNG
(US9029559, 323)
Show SMILES COc1ccc(nc1-c1cc(C)ccc1Cl)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20ClFN2O4/c1-13-7-8-16(24)15(11-13)22-20(31-2)10-9-18(26-22)23(30)27-19(12-21(28)29)14-5-3-4-6-17(14)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 2.31E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156984
PNG
(US9029559, 427)
Show SMILES COc1ccc(nc1-c1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C26H21ClN2O4/c1-33-23-13-12-21(28-25(23)18-11-10-16-6-2-3-7-17(16)14-18)26(32)29-22(15-24(30)31)19-8-4-5-9-20(19)27/h2-14,22H,15H2,1H3,(H,29,32)(H,30,31)/t22-/m0/s1
PDB

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US Patent
n/an/a 7.11E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156986
PNG
(US9029559, 429)
Show SMILES COc1ccc(nc1-c1cccc(C)c1)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O4/c1-14-6-5-7-15(12-14)22-20(30-2)11-10-18(25-22)23(29)26-19(13-21(27)28)16-8-3-4-9-17(16)24/h3-12,19H,13H2,1-2H3,(H,26,29)(H,27,28)/t19-/m0/s1
PDB

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US Patent
n/an/a 335n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47319
PNG
(US9029559, 216)
Show SMILES COc1ccc(nc1-c1cccnc1)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H21N3O4/c1-14-5-7-15(8-6-14)18(12-20(26)27)25-22(28)17-9-10-19(29-2)21(24-17)16-4-3-11-23-13-16/h3-11,13,18H,12H2,1-2H3,(H,25,28)(H,26,27)/t18-/m0/s1
PDB

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n/an/a>1.00E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair