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104 similar compounds to monomer 156865

Compile data set for download or QSAR
Wt: 422.4
BDBM47277
Wt: 395.3
BDBM47325
Wt: 426.4
BDBM156854
Wt: 426.4
BDBM47332
Wt: 426.4
BDBM156785
Wt: 426.4
BDBM156788
Wt: 426.4
BDBM156789
Wt: 458.8
BDBM156882
Wt: 446.8
BDBM156883
Wt: 442.8
BDBM156885
Wt: 428.8
BDBM156983
Wt: 440.8
BDBM156985
Wt: 422.4
BDBM156792
Wt: 422.4
BDBM156794
Wt: 446.8
BDBM156886
Displayed 1 to 15 (of 104 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 47277,47325,156854,47332,156785,156788,156789,156882,156883,156885,156983,156985,156792,156794,156886   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47325
PNG
(US9029559, 282)
Show SMILES COc1ccc(nc1-c1ccncc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C21H18FN3O4/c1-29-18-7-6-16(24-20(18)13-8-10-23-11-9-13)21(28)25-17(12-19(26)27)14-4-2-3-5-15(14)22/h2-11,17H,12H2,1H3,(H,25,28)(H,26,27)/t17-/m0/s1
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US Patent
n/an/a>1.00E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156985
PNG
(US9029559, 428)
Show SMILES COc1ccccc1-c1nc(ccc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O5/c1-30-19-10-6-4-8-15(19)22-20(31-2)12-11-17(25-22)23(29)26-18(13-21(27)28)14-7-3-5-9-16(14)24/h3-12,18H,13H2,1-2H3,(H,26,29)(H,27,28)/t18-/m0/s1
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US Patent
n/an/a 116n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156785
PNG
(US9029559, 212)
Show SMILES COc1ccc(nc1-c1cccc(F)c1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20F2N2O4/c1-13-14(7-5-9-16(13)24)22-20(31-2)11-10-18(26-22)23(30)27-19(12-21(28)29)15-6-3-4-8-17(15)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 150n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156788
PNG
(US9029559, 217)
Show SMILES COc1ccc(nc1-c1cccc(F)c1F)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H20F2N2O4/c1-13-6-8-14(9-7-13)18(12-20(28)29)27-23(30)17-10-11-19(31-2)22(26-17)15-4-3-5-16(24)21(15)25/h3-11,18H,12H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1
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n/an/a 90.2n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156789
PNG
(US9029559, 218)
Show SMILES COc1ccc(nc1-c1cc(F)ccc1F)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H20F2N2O4/c1-13-3-5-14(6-4-13)19(12-21(28)29)27-23(30)18-9-10-20(31-2)22(26-18)16-11-15(24)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 99.8n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156792
PNG
(US9029559, 221)
Show SMILES COc1ccc(nc1-c1ccc(F)cc1C)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23FN2O4/c1-14-4-6-16(7-5-14)20(13-22(28)29)27-24(30)19-10-11-21(31-3)23(26-19)18-9-8-17(25)12-15(18)2/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 239n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156794
PNG
(US9029559, 223)
Show SMILES COc1ccc(nc1-c1ccc(C)c(F)c1)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23FN2O4/c1-14-4-7-16(8-5-14)20(13-22(28)29)27-24(30)19-10-11-21(31-3)23(26-19)17-9-6-15(2)18(25)12-17/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.29E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156854
PNG
(US9029559, 288)
Show SMILES COc1ccc(nc1-c1ccc(F)cc1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20F2N2O4/c1-13-11-14(24)7-8-15(13)22-20(31-2)10-9-18(26-22)23(30)27-19(12-21(28)29)16-5-3-4-6-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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n/an/a 394n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47277
PNG
(BDB47277 | US9029559, 289)
Show SMILES COc1ccc(nc1-c1cccc(C)c1C)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C24H23FN2O4/c1-14-7-6-9-16(15(14)2)23-21(31-3)12-11-19(26-23)24(30)27-20(13-22(28)29)17-8-4-5-10-18(17)25/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 52.8n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156882
PNG
(US9029559, 319)
Show SMILES COc1cc(ccc1Cl)-c1nc(ccc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20ClFN2O5/c1-31-19-10-9-17(26-22(19)13-7-8-15(24)20(11-13)32-2)23(30)27-18(12-21(28)29)14-5-3-4-6-16(14)25/h3-11,18H,12H2,1-2H3,(H,27,30)(H,28,29)/t18-/m0/s1
PDB

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n/an/a>1.00E+4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156883
PNG
(US9029559, 320)
Show SMILES COc1ccc(nc1-c1cccc(Cl)c1F)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C22H17ClF2N2O4/c1-31-18-10-9-16(26-21(18)13-6-4-7-14(23)20(13)25)22(30)27-17(11-19(28)29)12-5-2-3-8-15(12)24/h2-10,17H,11H2,1H3,(H,27,30)(H,28,29)/t17-/m0/s1
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n/an/a 48.4n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156885
PNG
(US9029559, 323)
Show SMILES COc1ccc(nc1-c1cc(C)ccc1Cl)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C23H20ClFN2O4/c1-13-7-8-16(24)15(11-13)22-20(31-2)10-9-18(26-22)23(30)27-19(12-21(28)29)14-5-3-4-6-17(14)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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n/an/a 2.31E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156886
PNG
(US9029559, 324)
Show SMILES COc1ccc(nc1-c1cccc(F)c1Cl)C(=O)N[C@@H](CC(O)=O)c1ccccc1F
Show InChI InChI=1S/C22H17ClF2N2O4/c1-31-18-10-9-16(26-21(18)13-6-4-8-15(25)20(13)23)22(30)27-17(11-19(28)29)12-5-2-3-7-14(12)24/h2-10,17H,11H2,1H3,(H,27,30)(H,28,29)/t17-/m0/s1
PDB

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n/an/a 1.27E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156983
PNG
(US9029559, 426)
Show SMILES COc1ccc(nc1-c1cccc(F)c1)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClFN2O4/c1-30-19-10-9-17(25-21(19)13-5-4-6-14(24)11-13)22(29)26-18(12-20(27)28)15-7-2-3-8-16(15)23/h2-11,18H,12H2,1H3,(H,26,29)(H,27,28)/t18-/m0/s1
PDB

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US Patent
n/an/a 1.54E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47332
PNG
(US9029559, 366)
Show SMILES COc1ccc(nc1-c1cc(F)ccc1F)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C23H20F2N2O4/c1-13-5-3-4-6-15(13)19(12-21(28)29)27-23(30)18-9-10-20(31-2)22(26-18)16-11-14(24)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 121n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair