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97 similar compounds to monomer 156917

Compile data set for download or QSAR
Wt: 391.4
BDBM47316
Wt: 426.4
BDBM47332
Wt: 391.4
BDBM47331
Wt: 421.4
BDBM47343
Wt: 440.8
BDBM156985
Wt: 418.4
BDBM156793
Wt: 418.4
BDBM156795
Wt: 390.4
BDBM156690
Wt: 422.4
BDBM156796
Wt: 461.5
BDBM156798
Wt: 438.4
BDBM156800
Wt: 454.9
BDBM156801
Wt: 410.8
BDBM156892
Wt: 440.8
BDBM156897
Wt: 424.8
BDBM156898
Displayed 1 to 15 (of 97 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 47316,47332,47331,47343,156985,156793,156795,156690,156796,156798,156800,156801,156892,156897,156898   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47316
PNG
(US9029559, 215)
Show SMILES COc1ccc(nc1-c1ccncc1)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H21N3O4/c1-14-3-5-15(6-4-14)18(13-20(26)27)25-22(28)17-7-8-19(29-2)21(24-17)16-9-11-23-12-10-16/h3-12,18H,13H2,1-2H3,(H,25,28)(H,26,27)/t18-/m0/s1
PDB

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UniChem

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US Patent
n/an/a 9.66E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156985
PNG
(US9029559, 428)
Show SMILES COc1ccccc1-c1nc(ccc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O5/c1-30-19-10-6-4-8-15(19)22-20(31-2)12-11-17(25-22)23(29)26-18(13-21(27)28)14-7-3-5-9-16(14)24/h3-12,18H,13H2,1-2H3,(H,26,29)(H,27,28)/t18-/m0/s1
PDB

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US Patent
n/an/a 116n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47332
PNG
(US9029559, 366)
Show SMILES COc1ccc(nc1-c1cc(F)ccc1F)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C23H20F2N2O4/c1-13-5-3-4-6-15(13)19(12-21(28)29)27-23(30)18-9-10-20(31-2)22(26-18)16-11-14(24)7-8-17(16)25/h3-11,19H,12H2,1-2H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 121n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47343
PNG
(US9029559, 468)
Show SMILES COc1ccc(nc1-c1cccnc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C23H23N3O5/c1-14-7-4-5-8-15(14)18(13-20(27)28)26-22(29)17-10-11-19(30-2)21(25-17)16-9-6-12-24-23(16)31-3/h4-12,18H,13H2,1-3H3,(H,26,29)(H,27,28)/t18-/m0/s1
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US Patent
n/an/a 347n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156690
PNG
(US9029559, 44)
Show SMILES COc1ccccc1-c1cccc(n1)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C23H22N2O4/c1-15-8-3-4-9-16(15)20(14-22(26)27)25-23(28)19-12-7-11-18(24-19)17-10-5-6-13-21(17)29-2/h3-13,20H,14H2,1-2H3,(H,25,28)(H,26,27)/t20-/m0/s1
PDB

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US Patent
n/an/a 1.19E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156793
PNG
(US9029559, 222)
Show SMILES COc1ccc(nc1-c1cccc(C)c1C)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C25H26N2O4/c1-15-8-10-18(11-9-15)21(14-23(28)29)27-25(30)20-12-13-22(31-4)24(26-20)19-7-5-6-16(2)17(19)3/h5-13,21H,14H2,1-4H3,(H,27,30)(H,28,29)/t21-/m0/s1
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US Patent
n/an/a 37n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156795
PNG
(US9029559, 224)
Show SMILES COc1ccc(nc1-c1ccc(C)cc1C)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C25H26N2O4/c1-15-5-8-18(9-6-15)21(14-23(28)29)27-25(30)20-11-12-22(31-4)24(26-20)19-10-7-16(2)13-17(19)3/h5-13,21H,14H2,1-4H3,(H,27,30)(H,28,29)/t21-/m0/s1
PDB

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US Patent
n/an/a 3.39E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156796
PNG
(US9029559, 225)
Show SMILES COc1ccc(nc1-c1ccc(F)c(C)c1)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23FN2O4/c1-14-4-6-16(7-5-14)20(13-22(28)29)27-24(30)19-10-11-21(31-3)23(26-19)17-8-9-18(25)15(2)12-17/h4-12,20H,13H2,1-3H3,(H,27,30)(H,28,29)/t20-/m0/s1
PDB

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US Patent
n/an/a 3.26E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156798
PNG
(US9029559, 228)
Show SMILES COc1ccc(nc1-c1ccccc1C(=O)N(C)C)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C26H27N3O5/c1-16-9-11-17(12-10-16)21(15-23(30)31)28-25(32)20-13-14-22(34-4)24(27-20)18-7-5-6-8-19(18)26(33)29(2)3/h5-14,21H,15H2,1-4H3,(H,28,32)(H,30,31)/t21-/m0/s1
PDB

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US Patent
n/an/a 3.96E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156800
PNG
(US9029559, 231)
Show SMILES COc1ccc(nc1-c1ccc(F)cc1OC)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23FN2O5/c1-14-4-6-15(7-5-14)19(13-22(28)29)27-24(30)18-10-11-20(31-2)23(26-18)17-9-8-16(25)12-21(17)32-3/h4-12,19H,13H2,1-3H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 305n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156801
PNG
(US9029559, 232)
Show SMILES COc1ccc(nc1-c1ccc(Cl)cc1OC)C(=O)N[C@@H](CC(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H23ClN2O5/c1-14-4-6-15(7-5-14)19(13-22(28)29)27-24(30)18-10-11-20(31-2)23(26-18)17-9-8-16(25)12-21(17)32-3/h4-12,19H,13H2,1-3H3,(H,27,30)(H,28,29)/t19-/m0/s1
PDB

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US Patent
n/an/a 2.33E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156892
PNG
(US9029559, 330)
Show SMILES COc1ccc(nc1-c1ccccc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN2O4/c1-29-19-12-11-17(24-21(19)14-7-3-2-4-8-14)22(28)25-18(13-20(26)27)15-9-5-6-10-16(15)23/h2-12,18H,13H2,1H3,(H,25,28)(H,26,27)/t18-/m0/s1
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n/an/a 75.1n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156897
PNG
(US9029559, 335)
Show SMILES COc1ccc(cc1)-c1nc(ccc1OC)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O5/c1-30-15-9-7-14(8-10-15)22-20(31-2)12-11-18(25-22)23(29)26-19(13-21(27)28)16-5-3-4-6-17(16)24/h3-12,19H,13H2,1-2H3,(H,26,29)(H,27,28)/t19-/m0/s1
PDB

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n/an/a 2.25E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM156898
PNG
(US9029559, 336)
Show SMILES COc1ccc(nc1-c1ccc(C)cc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H21ClN2O4/c1-14-7-9-15(10-8-14)22-20(30-2)12-11-18(25-22)23(29)26-19(13-21(27)28)16-5-3-4-6-17(16)24/h3-12,19H,13H2,1-2H3,(H,26,29)(H,27,28)/t19-/m0/s1
PDB

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US Patent
n/an/a 3.13E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair
Cathepsin A (CTSA)


(Homo sapiens (Human))
BDBM47331
PNG
(US9029559, 365)
Show SMILES COc1ccc(nc1-c1ccncc1)C(=O)N[C@@H](CC(O)=O)c1ccccc1C
Show InChI InChI=1S/C22H21N3O4/c1-14-5-3-4-6-16(14)18(13-20(26)27)25-22(28)17-7-8-19(29-2)21(24-17)15-9-11-23-12-10-15/h3-12,18H,13H2,1-2H3,(H,25,28)(H,26,27)/t18-/m0/s1
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n/an/a 5.45E+3n/an/an/an/a5.525



SANOFI

US Patent


Assay Description
The activated cathepsin A was diluted in assay buffer (25 mM MES, pH 5.5, containing 5 mM DTT) and mixed with the test compound (dissolved in assay b...


US Patent US9029559 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DW7
More data for this
Ligand-Target Pair